Preparation of PLA/PDA/Ag Porous Antibacterial Nanofibrous Membrane by One-step and Their Effect on Promoting Wound Healing
TENG Guixiang1,*, YANG Yifan2,3, HOU Sutong3, YAO Hui1, ZHANG Chun3,*
1 School of Biological and Pharmaceutical Engineering,Lanzhou Jiaotong University, Lanzhou 730070, China 2 WuXi PharmaTech,Tianjin 300457, China 3 School of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China
Abstract: Effective control the irregular flow of wound biological fluid and prevention of wound infection remain significant challenges in promoting wound healing and skin regeneration. In this study, a PLA/PDA/Ag nanofibrous membrane with exudate adsorption, wound antibacterial and mechanical properties was prepared by a one-step method of ‘electrospinning + in-situ crosslinking’. After testing the chemical composition, internal structure and mechanical properties of the fibrous membrane, it was used in antibacteria and wound healing experiments to verify the practical application on wound healing. The results showed that the water absorption of PLA/PDA/Ag fibrous membrane can reached 65.0% and the water contact angle is 72.35°, which can contribute to the obvious adsorption and diversion effect on the wound exudate. The diameter of inhibition zones of S.ureus and E.coli were (25.4±0.6) mm and (28.7±0.9) mm, respectively when treated with the PLA/PDA/Ag fibrous membrane. The skin wound healing of mice reached 95.3% on the 9th day after treated with the membrane, with no infection occurred, and the wound contraction rate was significantly better than that of the control. The hydrophilicity, antibacterial property and stretchability of the PLA/PDA/Ag fibrous membrane prepared in this study can be adjusted by the addition ratio of DA, and then be used in different wound fields, which has certain application prospects in the field of wound accessory design.
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2023, Vol. 37 
