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材料导报  2022, Vol. 36 Issue (11): 21010039-7    https://doi.org/10.11896/cldb.21010039
  高分子与聚合物基复合材料 |
静电纺丝聚己内酯/明胶载姜黄素生物活性敷料的制备和性能
李曼, 武丁胜, 魏安方, 刘锁, 赵玲玲, 王衡, 王克付, 凤权
安徽工程大学,安徽省纺织面料重点实验室,安徽 芜湖 241000
Preparation and Performance of Electrospinning Curcumin Loaded Polycaprolactone/Gelatin Bioactive Wound Dressing
LI Man, WU Dingsheng, WEI Anfang, LIU Suo, ZHAO Lingling, WANG Heng, WANG Kefu, FENG Quan
Anhui Provincial Key Laboratory of Textile Fabrics, Anhui Polytechnic University, Wuhu 241000, Anhui, China
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摘要 姜黄素是一种从姜黄中提取的具有抗炎、抗氧化、促进伤口愈合等药理活性的一种多酚类化合物,广泛应用于食品保鲜和医学等领域,但是姜黄素结晶度高,导致其生物利用率不高。针对这个问题,本工作采用静电纺丝技术,将姜黄素负载在聚己内酯(PCL)/明胶(Gelatin)纳米纤维中,探究不同聚己内酯和明胶质量比对纳米纤维膜形态、结晶性、热稳定性、吸湿透气性和姜黄素释放行为及抗氧化性等的影响。X射线衍射(XRD)、差示扫描量热(DSC)测试结果表明,经过静电纺丝之后,纤维膜中的姜黄素以无定形的状态存在。纤维膜的吸水性与明胶含量呈正相关,并且高于市售水胶体敷料,水蒸气透过率与两层纱布相当。体外释药实验和抗氧化性测试表明,姜黄素的累计释放率和自由基清除率随着纤维膜中明胶比例的增大而提高。通过拟合零级、一级、Higuchi和Ritger-Peppas释药数学模型对姜黄素的释放行为进行分析,三种载药纤维膜的药物释放曲线对一级释放动力学方程的拟合系数最高,并且药物释放行为符合Fick扩散机制。
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李曼
武丁胜
魏安方
刘锁
赵玲玲
王衡
王克付
凤权
关键词:  静电纺丝  聚己内酯  明胶  姜黄素  释放动力学  抗氧化    
Abstract: Curcumin is a polyphenolic compound extracted from turmeric with anti-inflammatory, anti-oxidant, wound healing and other pharmacological activities. It is widely used in food preservation and medicine fields. However, the high crystallinity of curcumin causes its low bioavailability. To solve this problem, electrospinning technology was adopted to load curcumin in PCL/Gelatin nanofibers, and the effect of different mass ratios of polycaprolactone and gelatin on nanofiber membrane's morphology, crystallinity, thermal stability, water uptake capability, water vapor transmission rate, curcumin's release behavior and antioxidant properties was explored in this work. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) curves showed that curcumin in the fiber membrane was amorphous after electrospinning. The water uptake capability of the fiber membrane was positively correlated with the gelatin content and was higher than that of commercial hydrocolloid dressings, while the water vapor transmission rate was equivalent to that of two-layer gauze. Vitro drug release and antioxidant tests showed that the cumulative release rate and free radical scavenging rate of curcumin went up with the increase of the proportion of gelatin in the fiber membrane. The release behaviors of curcumin was analyzed by fitting zero-order, first-order, and Higuchi and Ritger-Peppas drug release mathematical models. The drug release curves of the drug-loaded fiber membranes have the highest fitting coefficients to the first-order release kinetic equation, and the drug release behaviors conformed to the Fick diffusion mechanism.
Key words:  electrospinning    polycaprolactone    gelatin    curcumin    release kinetics    antioxidant
发布日期:  2022-06-09
ZTFLH:  TQ34  
基金资助: 安徽省自然科学基金(2008085ME139);安徽工程大学纺织服装学院大学生科研项目(2020ffky04)
通讯作者:  fengquan@ahpu.edu.cn   
作者简介:  李曼,2018年和2021年在安徽工程大学纺织服装学院分别获得学士学位和硕士学位,研究方向为功能性纳米纤维。发表学术论文3篇,授权3项国家发明专利。
凤权,安徽工程大学教授,1999年和2007年在安徽工程大学分别获得学士学位和硕士学位,2012年在江南大学获得工学博士学位,美国南达科他州矿业理工学院(SDSMT)访问学者,研究方向主要包括功能性纤维制备及其在生物催化、环境治理、生物医药等领域的应用。主持并完成国家自然科学基金、安徽省自然科学基金、安徽高校省级自然科学研究重大项目、国家特种显示工程技术研究中心开放课题、生态纺织教育部重点实验室开放课题等10余项国家级、省级科研项目。先后发表国内外研究论文近60篇,其中SCI收录近30篇,申报并授权发明专利8项。
引用本文:    
李曼, 武丁胜, 魏安方, 刘锁, 赵玲玲, 王衡, 王克付, 凤权. 静电纺丝聚己内酯/明胶载姜黄素生物活性敷料的制备和性能[J]. 材料导报, 2022, 36(11): 21010039-7.
LI Man, WU Dingsheng, WEI Anfang, LIU Suo, ZHAO Lingling, WANG Heng, WANG Kefu, FENG Quan. Preparation and Performance of Electrospinning Curcumin Loaded Polycaprolactone/Gelatin Bioactive Wound Dressing. Materials Reports, 2022, 36(11): 21010039-7.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.21010039  或          http://www.mater-rep.com/CN/Y2022/V36/I11/21010039
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