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材料导报  2022, Vol. 36 Issue (6): 20060050-9    https://doi.org/10.11896/cldb.20060050
  高分子与聚合物基复合材料 |
基于天然多糖的水凝胶伤口敷料的研究进展
王通1, 王广飞1, 张淑敏2,3, 曲承蕾4, 李诚博2,4, 高永林1
1 烟台大学生命科学学院,山东 烟台 264005
2 山东国际生物科技园发展有限公司,山东 烟台 264670
3 滨州医学院药学院,山东 烟台 264003
4 烟台蓝创生物技术有限公司,山东 烟台 264670
Research Progress of Hydrogel Wound Dressing Based on Natural Polysaccharides
WANG Tong1, WANG Guangfei1, ZHANG Shumin2,3, QU Chenglei4, LI Chengbo2,4, GAO Yonglin1
1 College of Life Science, Yantai University, Yantai 264005,Shandong, China
2 Shandong International Biotechnology Park Development Co., Ltd., Yantai 264670,Shandong, China
3 School of Pharmacy, Binzhou Medical University, Yantai 264003,Shandong, China
4 Yantai Blue Bio-technology Co., Ltd., Yantai 264670,Shandong, China
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摘要 在日常生活中,烧烫伤和割伤造成的皮肤急性损伤时有发生,难以正常愈合且有持续性炎症的慢性伤口也较为常见。有效的伤口敷料不仅可以遮盖与保护伤口,而且能提高伤口愈合的质量。水凝胶具有孔隙率高、含水量高和生物相容性良好等特点,在临床治疗和组织工程等领域具有广阔的应用前景。
常见水凝胶的合成方法包括物理交联法和化学交联法,使用不同基材以及合成方法制备的水凝胶具有不同的特点。一般来说,使用多糖制备的天然水凝胶在力学性能和稳定性方面不如人工聚合物水凝胶,且单一多糖水凝胶可能无法满足伤口愈合的多元化需求。因此,高力学性能的杂化双交联水凝胶和高抗菌性、高生物相容性的功能复合水凝胶是当前的研究热点和趋势。
本文介绍了几种常见的用于水凝胶合成的多糖以及多糖水凝胶的合成方法与分类,并对近年来的功能性复合水凝胶敷料进行了分类归纳,然后对多糖水凝胶敷料的相关动物实验、临床应用及商业化产品进行了概述。期望能够为从事本领域的相关研究人员提供部分参考。
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王通
王广飞
张淑敏
曲承蕾
李诚博
高永林
关键词:  天然多糖  水凝胶  伤口敷料  伤口愈合    
Abstract: Acute skin injuries and persistent non-healing chronic wounds are common in daily life. Dressings are playing critical roles in wound care because they can protect the wound from external infection and accelerate the healing process. With the characteristics of high porosity, high water content and good biocompatibility, hydrogel dressings have broad application prospects in clinical treatment and tissue engineering.
The synthesis methods of hydrogels include the physical cross-linking method and the chemical cross-linking method. Hydrogels prepared by different synthesis methods or different substrates often have different characteristics. Natural polysaccharide hydrogels are far inferior to artificial polymer hydrogels in terms of mechanical properties and stability, and a single polysaccharide hydrogel material may not be able to meet the diversified needs of wound healing. At present, the focus of research is the hybrid double-crosslinked hydrogel which can improve its mechanical properties, and the multi-functional composite hydrogel with antimicrobial properties and biocompatibility.
This review gives a summary on the the types of polysaccharides used for hydrogels, the preparation methods and classification of hydrogels based on polysaccharides, and the functional composite hydrogel dressings. In addition, it summarizes the animal experiments, clinical applications and commercial products of hydrogel dressings based on polysaccharides. It hopes to provide a certain reference for relevant researchers in this field.
Key words:  natural polysaccharide    hydrogel    wound dressing    wound healing
出版日期:  2022-03-25      发布日期:  2022-03-21
ZTFLH:  R318.08  
基金资助: 烟台市科技计划项目(2020XDRH109);山东半岛国家自主创新示范区发展建设资金项目(ZCQ19111)
通讯作者:  lichengbo@luyetz.com;gaoyonglin@ytu.edu.cn   
作者简介:  王通,2018年6月毕业于烟台大学,获得工学学士学位。现为烟台大学生命科学学院硕士研究生,在高永林副教授的指导下进行研究。主要研究领域为水凝胶材料的制备、表征与评价。
高永林,烟台大学副教授,硕士研究生导师。从事药品、功能食品及医疗器械的生物学及安全性评价工作。在Journal of Bioactive and Compatible Polymer、Journal of Biomaterials Applications等杂志发表SCI论文30余篇。
李诚博,中国海洋大学博士,烟台蓝创生物技术有限公司研发经理,研究方向为海洋生物材料,主要从事海洋生物材料的应用与修饰等相关研究,具有海洋生物医药材料产品开发和技术服务的经验。发表论文7篇,其中SCI收录3篇、中文核心期刊收录4篇。拥有国家发明专利3项。
引用本文:    
王通, 王广飞, 张淑敏, 曲承蕾, 李诚博, 高永林. 基于天然多糖的水凝胶伤口敷料的研究进展[J]. 材料导报, 2022, 36(6): 20060050-9.
WANG Tong, WANG Guangfei, ZHANG Shumin, QU Chenglei, LI Chengbo, GAO Yonglin. Research Progress of Hydrogel Wound Dressing Based on Natural Polysaccharides. Materials Reports, 2022, 36(6): 20060050-9.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.20060050  或          http://www.mater-rep.com/CN/Y2022/V36/I6/20060050
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