Research Progress of Hydrogel Wound Dressing Based on Natural Polysaccharides
WANG Tong1, WANG Guangfei1, ZHANG Shumin2,3, QU Chenglei4, LI Chengbo2,4, GAO Yonglin1
1 College of Life Science, Yantai University, Yantai 264005,Shandong, China 2 Shandong International Biotechnology Park Development Co., Ltd., Yantai 264670,Shandong, China 3 School of Pharmacy, Binzhou Medical University, Yantai 264003,Shandong, China 4 Yantai Blue Bio-technology Co., Ltd., Yantai 264670,Shandong, China
Abstract: Acute skin injuries and persistent non-healing chronic wounds are common in daily life. Dressings are playing critical roles in wound care because they can protect the wound from external infection and accelerate the healing process. With the characteristics of high porosity, high water content and good biocompatibility, hydrogel dressings have broad application prospects in clinical treatment and tissue engineering. The synthesis methods of hydrogels include the physical cross-linking method and the chemical cross-linking method. Hydrogels prepared by different synthesis methods or different substrates often have different characteristics. Natural polysaccharide hydrogels are far inferior to artificial polymer hydrogels in terms of mechanical properties and stability, and a single polysaccharide hydrogel material may not be able to meet the diversified needs of wound healing. At present, the focus of research is the hybrid double-crosslinked hydrogel which can improve its mechanical properties, and the multi-functional composite hydrogel with antimicrobial properties and biocompatibility. This review gives a summary on the the types of polysaccharides used for hydrogels, the preparation methods and classification of hydrogels based on polysaccharides, and the functional composite hydrogel dressings. In addition, it summarizes the animal experiments, clinical applications and commercial products of hydrogel dressings based on polysaccharides. It hopes to provide a certain reference for relevant researchers in this field.
作者简介: 王通,2018年6月毕业于烟台大学,获得工学学士学位。现为烟台大学生命科学学院硕士研究生,在高永林副教授的指导下进行研究。主要研究领域为水凝胶材料的制备、表征与评价。 高永林,烟台大学副教授,硕士研究生导师。从事药品、功能食品及医疗器械的生物学及安全性评价工作。在Journal of Bioactive and Compatible Polymer、Journal of Biomaterials Applications等杂志发表SCI论文30余篇。 李诚博,中国海洋大学博士,烟台蓝创生物技术有限公司研发经理,研究方向为海洋生物材料,主要从事海洋生物材料的应用与修饰等相关研究,具有海洋生物医药材料产品开发和技术服务的经验。发表论文7篇,其中SCI收录3篇、中文核心期刊收录4篇。拥有国家发明专利3项。
引用本文:
王通, 王广飞, 张淑敏, 曲承蕾, 李诚博, 高永林. 基于天然多糖的水凝胶伤口敷料的研究进展[J]. 材料导报, 2022, 36(6): 20060050-9.
WANG Tong, WANG Guangfei, ZHANG Shumin, QU Chenglei, LI Chengbo, GAO Yonglin. Research Progress of Hydrogel Wound Dressing Based on Natural Polysaccharides. Materials Reports, 2022, 36(6): 20060050-9.
1 Namazi H, Rakhshaei R, Hamishehkar H, et al. International Journal of Biological Macromolecules, 2016, 85, 327. 2 Li L, Yu F, Zheng L, et al. Journal of Orthopaedic Translation, 2019, 17, 26. 3 Mondal S, Das S, Nandi A K. Soft Matter, 2020, 16(6), 1404. 4 Darge H F, Andrgie A T, Tsai H C, et al. International Journal of Biological Macromolecules, 2019, 133, 545. 5 Zhao X, Wu H, Guo B, et al. Biomaterials, 2017, 122, 34. 6 Liu H, Wang C Y, Li C, et al. RSC Advances, 2018, 8(14), 7533. 7 Anitha A, Sowmya S, Kumar P T S, et al. Progress in Polymer Science, 2014, 39(9), 1644. 8 Koehler J, Brandl F P, Goepferich A M. European Polymer Journal, 2018, 100, 1. 9 Dutta S D, Patel D K, Lim K T. Journal of Biological Engineering, 2019, 13, 55. 10 Freudenberg U, Liang Y, Kiick K L, et al. Advanced Materials, 2016, 28(40), 8861. 11 Hoffman A S. Advanced Drug Delivery Reviews, 2012, 64, 18. 12 Liu L S, Kost J, Yan F, et al. Polymers, 2012, 4(2), 997. 13 Zhu F B. Toughening, structuring and functionalization of hydrogels. Ph.D. Thesis, Zhejiang University, China, 2018 (in Chinese). 朱凤博. 水凝胶的强韧化、结构化及功能化研究. 博士学位论文, 浙江大学, 2018. 14 Hu X M. Preparation of dextran-based hydrogel. Master's Thesis, Changchun University of Technology, China, 2020 (in Chinese). 胡雪梅. 葡聚糖水凝胶的制备. 硕士学位论文, 长春工业大学, 2020. 15 Alam M N, Islam M S, Christopher L P. ACS Omega, 2019, 4(5), 9419. 16 Zhang Y B, Dang Q F, Liu C S, et al. International Journal of Biological Macromolecules, 2017, 102, 457. 17 Carvalho I C, Mansur H S. Materials Science and Engineering: C, 2017, 78, 690. 18 Xu X L, Zhou G Q, Li X J, et al. Fibers and Polymers, 2016, 17(2), 205. 19 Rezvanian M, Ahmad N, Amin M, et al. International Journal of Biological Macromolecules, 2017, 97, 131. 20 Singh B, Varshney L, Francis S, et al. International Journal of Biological Macromolecules, 2016, 88, 586. 21 Wu T, Huang J, Jiang Y, et al. Food Chemistry, 2018, 240, 361. 22 Zhang Y F. Preparation and properties of injectable composite hydrogels based on modified hyaluronic acid and sodium alginate. Master's Thesis, Southwest University of Science and Technology, China, 2019 (in Chinese). 张宇帆. 可注射改性透明质酸/海藻酸钠复合水凝胶的制备及性能研究. 硕士学位论文, 西南科技大学, 2019. 23 Ying H Y. Research on collagen-glycosaminoglycan biomaterials and its applications in tissue engineering. Master's Thesis, Jiangnan University, China, 2019 (in Chinese). 应慧妍. 基于胶原蛋白-糖胺聚糖的生物材料研究及其在组织工程中的应用. 硕士学位论文, 江南大学, 2019. 24 曹一平, 郑志强, 贝中武, 等. 中国专利, CN108264611B, 2020. 25 Hebeish A, Sharaf S. RSC Advances, 2015, 5(125), 103036. 26 Rakhshaei R, Namazi H. Materials Science and Engineering: C, 2017, 73, 456. 27 Shen X, Shamshina J L, Berton P, et al. Green Chemistry, 2016, 18(1), 53. 28 Hou J, Li C, Guan Y, et al. Polymer Chemistry, 2015, 6(12), 2204. 29 毛宏理, 顾忠伟, 何雨芯.中国专利, CN111662464A, 2020. 30 吴德成, 补亚忠.中国专利, CN106519264B, 2019. 31 王征科, 乔丰慧, 裴伯映, 等. 中国专利, CN110818917B,2020. 32 Omidi M, Yadegari A, Tayebi L. RSC Advances, 2017, 7(18), 10638. 33 Thet N T, Alves D R, Bean J E, et al. ACS Applied Materials & Interfaces, 2016, 8(24), 14909. 34 Bajpai S K, Pathak V, Soni B. International Journal of Biological Macromolecules, 2015, 79, 76. 35 Singh B, Dhiman A. RSC Advances, 2015, 5(55), 44666. 36 Koosehgol S, Ebrahimian-Hosseinabadi M, Alizadeh M, et al. Materials Science and Engineering: C, 2017, 79, 66. 37 Kumar P T S, Lakshmanan V K, Anilkumar T V, et al. ACS Applied Materials & Interfaces, 2012, 4(5), 2618. 38 Chuysinuan P, Chimnoi N, Reuk-Ngam N, et al. Polymer Bulletin, 2019, 76(2), 701. 39 Babavalian H, Latifi A M, Shokrgozar M A, et al. Jundishapur Journal of Microbiology, 2015, 8(9), e28320. 40 Ma M, Zhong Y, Jiang X. Carbohydrate Polymers, 2020, 236, 116096. 41 Hsu L C, Peng B Y, Chen M S, et al. Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2019, 107(2), 278. 42 Gao T L, Jiang M H, Liu X Q, et al. Polymers, 2019, 11(1), 171. 43 Mohamad N, Loh E Y X, Fauzi M B, et al. Drug Delivery and Translational Research, 2019, 9(2), 444. 44 Yoon D S, Lee Y, Ryu H A, et al. Acta Biomaterialia, 2016, 38, 59. 45 Xia G X, Liu Y, Tian M P, et al. Journal of Materials Chemistry B, 2017, 5(17), 3172. 46 Yang D H, Seo D I, Lee D W, et al. Journal of Industrial and Enginee-ring Chemistry, 2017, 53, 360. 47 Yoo Y, Hyun H, Yoon S J, et al. Journal of Industrial and Engineering Chemistry, 2018, 67, 365. 48 Jaiswal M, Koul V, Dinda A K. Journal of Applied Polymer Science, 2016, 133(21),43272. 49 El-Naggar M Y, Gohar Y M, Sorour M A, et al. Journal of Microbiology and Biotechnology, 2016, 26(2), 408. 50 Romic M D, Klaric M S, Lovric J, et al. European Journal of Pharmaceutics and Biopharmaceutics, 2016, 107, 67. 51 Chen H N, Xing X D, Tan H P, et al. Materials Science and Enginee-ring: C, 2017, 70, 287. 52 Refat M S, Elsabawy K M, Alhadhrami A, et al. Journal of Molecular Liquids, 2018, 255, 462. 53 Miao T, Fenn S L, Charron P N, et al. Biomacromolecules, 2015, 16(12), 3740. 54 严励, 杨立群, 蓝碧云, 等.中国专利, CN111249520A,2020. 55 Francesko A, Petkova P, Tzanov T. Current Medicinal Chemistry, 2018, 25(41), 5782. 56 Zhu J, Han H, Ye T T, et al. Molecules, 2018, 23, 3383. 57 Liu H, Rong L, Wang B, et al. Carbohydrate Polymers, 2017, 176, 299. 58 Shi Y, Truong V X, Kulkarni K, et al. Journal of Materials Chemistry B, 2015, 3(45), 8771. 59 Giammanco G E, Carrion B, Coleman R M, et al. ACS Applied Materials & Interfaces, 2016, 8(23), 14423. 60 马列, 庞倩, 郑晓闻, 等. 中国专利, CN107496975B, 2020. 61 Xu Q, Sigen A, Gao Y S, et al. Acta Biomaterialia, 2018, 75, 63. 62 Ouyang Q Q, Zhang H, Lin Z P, et al. International Journal of Biological Macromolecules, 2018, 112, 1191. 63 Zhang X, Sun D, Jiang G C, et al. Journal of Diabetes, 2019, 11(6), 418. 64 Semenič D, Cirman T, Roman P, et al. Acta Clinica Croatica, 2018, 57(3), 434. 65 Lu L S, Xie C M, Lu J Y. Anti-Infection Pharmacy, 2017, 14(7), 1310(in Chinese). 卢林生, 谢春梅, 卢俊彦. 抗感染药学, 2017, 14(7), 1310. 66 Liu J, Zhang Z Y, Zhao J, et al. Medical & Pharmaceutical Journal of Chinese People's Liberation Army, 2019, 31(6), 54 (in Chinese). 刘静, 张振宇, 赵娟, 等. 解放军医药杂志, 2019, 31(6), 54. 67 Zhu Y L, Xiu X L, Su H T, et al. Infection,Inflammation,Repair, 2017, 18(1), 32(in Chinese). 朱应来, 徐秀玲, 苏海涛, 等. 感染、炎症、修复, 2017, 18(1), 32. 68 Wen X Q. Effectiveness and safety of alginate dressings in the treatment of diabetic foot ulcers: a meta-analysis. Master's Thesis, Jilin University, China, 2019 (in Chinese). 温小强. 藻酸盐敷料治疗糖尿病足溃疡的有效性及安全性的meta分析. 硕士学位论文. 吉林大学, 2019. 69 Isakson M, De Blacam C, Whelan D, et al. Stem Cells International, 2015, 2015, 831095.