Progress on Constructing of Self-healing Hydrogel Based on Dynamic Reversible Non-covalent System
YANG Jueying1, CHEN Yu1, ZHAO Lin1, ZHANG Zihan2, YANG Wei1, LIU Yuan3, PENG Kelin1, WANG Yalun1
1 School of Materials Science & Engineering, Beijing Institute of Technology,Beijing 100081, China; 2 Beijing Haidian Foreign Language Shi Yan School, Beijing 100195, China; 3 China Association of Environmental Protection Industry, Beijing 100037, China
Abstract: The integrity of materials is a prerequisite for ensuring their performance. Any damage or defect may result in materials not meeting the requirements of application. For all kinds of materials, self-healing properties are strongly needed, especially for the hydrogels used as drug delivery carriers, tissue engineering scaffolds and functional device coatings because of their special application requirements. Developing self-healing hydrogels which can heal itself to maintain its initial performance after being damaged is vital to ensure the safety and reliability of materials in the use cycle, and thus has attracted more and more attentions. In general, self-healing hydrogels can be divided into two types based on the forces between polymer chains. The first kind is formed by dynamic covalent bonds, including disulfide bonds, Diels-Alder cycloaddition reaction, imine bond/Schiff base interaction, etc. Others are formed by physically crosslinking of non-valent bonds like hydrogen bonds or van der Waals’ force, host-guest interaction, the interaction between polyelectrolyte, interaction of metal ligand, hydrophobic association, etc. Due to the stability of covalent bonds, most hydrogels formed by covalent bonds are stable and can exhibit good mechanical properties. Howe-ver, these hydrogels have many limitations, including poor response to external stimuli, inability to be remodeled after being manufactured, and unable to heal themselves after being damaged. Thus, the development of self-healing hydrogels based on dynamic covalent or physical crosslinking has become a trend. Self-healing hydrogel not only exhibit high swelling ratio and water content, biocompatibility and biodegradability, but also has the ability to repair the fault, which can be used for tissue engineering, wound dressing, drug release and biosensing fields, prolonging the lifespan of materials and showing excellent application potential. This review introduces the progress on the development of self-healing hydrogels based on dynamic reversible non-covalent system in recent years. The self-healing hydrogels are classified according to different healing mechanisms. The fabrication methods and application fields of self-healing hydrogels based on hydrogen bonding, reversible metal coordination, hydrophobic association and various interaction forces are reviewed respectively, and the problems and prospects of hydrogels based on dynamic reversible non-covalent system are discussed, aiming at providing ideas for the design, preparation and application of such hydrogels.
1 Xue W, Zhang X M. Biomedical Hydrogel, Jinan University Press, China, 2012(in Chinese). 薛巍,张渊明. 生物医用水凝胶, 暨南大学出版社,2012. 2 Ahmed E M. Journal of Advanced Research, 2015, 6(2), 105. 3 Naahidi S, Jafari M, Logan M, et al. Biotechnology Advances, 2017, 35(5), 530. 4 Bittner S M, Guo J L, Melchiorri A, et al. Materials Today, 2018, 21(8), 861. 5 Kim I L, Mauck R L, Burdick J A. Biomaterials, 2011, 32(34), 8771. 6 Malafaya P B, Silva G A, Reis R L. Advanced Drug Delivery Reviews, 2007, 59(4-5), 207. 7 Drury J L, Mooney D J. Biomaterials, 2003, 24(24), 4337. 8 Hynes R O. Science, 2009, 326(5957), 1216. 9 Sepantafar M, Maheronnaghsh R, Mohammadi H, et al. Biotechnology Advances, 2016, 34(4), 362. 10 Kuzmenko V, Samfors S, Hagg D, et al. Materials Science and Enginee-ring: C, 2013, 33(8), 4599. 11 Park S, Kim G, Jeon Y C, et al. Journal of Materials Science: Materials in Medicine, 2009, 20(1), 229. 12 Rederstorff E, Rethore G, Weiss P, et al. Journal of Tissue Engineering and Regenerative Medicine, 2017, 11(4), 1152. 13 Saludas L, Pascual-Gil S, Prósper F, et al. International Journal of Pharmaceutics, 2017, 523(2), 454. 14 Park M H, Subbiah R, Kwon M J, et al. Carbohydrate Polymers, 2018, 202, 488. 15 Xavier J R, Thakur T, Desai P, et al. ACS Nano, 2015, 9(3), 3109. 16 Radhakrishnan J, Krishnan U M, Sethuraman S. Biotechnology Advances, 2014, 32(2), 449. 17 Fathi P, Sikorski M, Christodoulides K, et al. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018, 106(5), 1662. 18 Shamloo A, Sarmadi M, Aghababaie Z, et al. International Journal of Pharmaceutics, 2018, 537(1-2), 278. 19 Ye B H, Meng L, Li L H, et al. Acta Polymerica Sinica, 2016(2), 134(in Chinese). 叶碧华,孟璐,李立华,等. 高分子学报, 2016(2),134. 20 Hao X, Liu H, Xie Y, et al. Colloid and Polymer Science, 2013, 291(7), 1749. 21 Tseng T, Hsieh F, Theato P, et al. Biomaterials, 2017, 133, 20. 22 Cheng C, Bai X, Zhang X, et al. Journal of Polymer Research, 2015, 22,46. 23 White S R, Sottos N R, Geubelle P H, et al. Nature, 2001, 409(6822), 794. 24 王朝阳,张光照. 中国专利, CN201710162761, 2017. 25 王路,李书彬,于雪梅,等. 中国专利,专利号CN107118357A, 2017. 26 Shao C, Chang H, Wang M, et al. ACS Applied Materials & Interfaces, 2017, 9(34), 28305. 27 Ni B, Xie H, Tang J, et al. Chemical Communications, 2016, 52(67), 10257. 28 Mamiya J, Yoshitake A, Kondo M, et al. Journal of Materials Chemistry, 2008, 18(1), 63. 29 Huo S J. Self-healing alginate hydrogels based on supramolecular interaction. Master’s Thesis, South China University of Technology, China, 2016(in Chinese). 霍双君. 基于超分子作用的可自修复海藻酸水凝胶. 硕士学位论文,华南理工大学,2016. 30 Ren B, Chen X, Du S, et al. International Journal of Biological Macromolecules, 2018, 118, 1257. 31 Yang L, Li Y, Gou Y, et al. Polymer Chemistry, 2017, 8(34),3071. 32 Fu F, Chen Z, Zhao Z, et al. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(23),5900. 33 Kang M, Liu S, Oderinde O, et al. Materials & Design, 2018, 148,96. 34 Shi L, Wang F, Zhu W, et al. Advanced Functional Materials, 2017, 27(37),1700591. 35 Wei Z, Yang J H, Liu Z Q, et al. Advanced Functional Materials, 2015, 25(9),1352. 36 Cheng C, Zhang X, Meng Y, et al. Soft Matter, 2017, 13(16),3003. 37 Luo F, Sun T L, Nakajima T, et al. Macromolecules, 2014, 47(17),6037. 38 Kakuta T, Takashima Y, Nakahata M, et al. Advanced Materials, 2013, 25(20),2849. 39 Cui J, Nie F, Yang J, et al. Journal of Materials Chemistry A, 2017, 5(48),25220. 40 林权,赵月,杨旭东,等. 中国专利, CN106009003A, 2016. 41 Gulyuz U, Okay O. Macromolecules, 2014, 47(19),6889. 42 Sun J C, Gao Y, Yang M, et al. Chemical Engineer, 2016, 30(7), 6(in Chinese). 孙嘉辰,高玥,杨梅,等. 化学工程师, 2016, 20(7), 6. 43 Haraguchi K, Uyama K, Tanimoto H. Macromolecular Rapid Communications, 2011, 32(16), 1253. 44 Zhang G, Ngai T, Deng Y, et al. Macromolecular Chemistry and Physics, 2016, 217(19), 2172. 45 Yanagisawa Y, Nan Y, Okuro K, et al. Science, 2018, 359(6371), 72. 46 Liu B, Wang Y, Miao Y, et al. Biomaterials, 2018, 171, 83. 47 Maes F, Montarnal D, Cantournet S, et al. Soft Matter, 2012, 8(5), 1681. 48 Gong G S, Liu J B, Zhong Y P, et al. Chemical Industry and Enginee-ring Progress,2016, 35(8), 2507(in Chinese). 龚桂胜,刘景勃,钟玉鹏,等. 化工进展, 2016, 35(8), 2507. 49 Dai X, Zhang Y, Gao L, et al. Advanced Materials, 2015, 27(23), 3566. 50 Balkenende D W R, Monnier C A, Fiore G L, et al. Nature Communications, 2016, 7(1), 10995. 51 Cui J, Del Campo A. Chemical Communications, 2012, 48(74), 9302. 52 Rong Q, Lei W, Chen L, et al. Angewandte Chemie, 2017, 56(45), 14159. 53 Zhi H, Fei X, Tian J, et al. Journal of Materials Chemistry B, 2017, 5(29), 5738. 54 Yu C, Geng J, Zhuang Y, et al. Carbohydrate Polymers, 2016, 152, 327. 55 Liang H, Zhang Z, Yuan Q, et al. Chemical Communications, 2015, 51(82), 15196. 56 Yang Q, Li X F, Long S J, et al. Acta Materiae Compositae Sinica, 2017,34(7),1416(in Chinese). 杨倩,李学锋,龙世军,等. 复合材料学报, 2017,34(7),1416. 57 Zhang K, Feng Q, Xu J, et al. Advanced Functional Materials, 2017, 27(34), 1701642. 58 Yavvari P S, Pal S, Kumar S, et al. ACS Biomaterials Science & Engineering, 2017, 3(12), 3404. 59 Casuso P, Odriozola I, Pérez-San Vicente A, et al. Biomacromolecules, 2015, 16(11), 3552. 60 Gantar A, Drnovsek N, Casuso P, et al. RSC Advances, 2016, 6(73), 69156. 61 Pérez-San Vicente A, Peroglio M, Ernst M, et al. Biomacromolecules, 2017, 18(8), 2360. 62 Qin H, Zhang T, Li H, et al. Chemistry, 2017, 3(4), 691. 63 Jiang G Q. Studies on preparation and properties of aqueous solutions and hydrogels of hydrophobically modified polyacrylamide. Master’s Thesis, Jilin University, China, 2010(in Chinese). 姜国庆. 疏水改性聚丙烯酰胺水溶液和水凝胶的制备与性质研究. 硕士学位论文,吉林大学,2010. 64 Tuncaboylu D C, Argun A, Sahin M, et al. Polymer, 2012, 53(24),5513. 65 Algi M P, Okay O. European Polymer Journal, 2014, 59,113. 66 Owusu-Nkwantabisah S, Gillmor J, Bennett G, et al. Polymer, 2018, 145,374. 67 Gu S, Duan L, Ren X, et al. Journal of Colloid and Interface Science, 2017, 492,119. 68 Chen Q, Zhu L, Chen H, et al. Advanced Functional Materials, 2015, 25(10),1598. 69 Zhang G, Lv L, Deng Y, et al. Macromolecular Rapid Communications, 2017, 38(12),1700018. 70 Kawamoto K, Grindy S C, Liu J, et al. ACS Macro Letters, 2015, 4(4),458. 71 Li S, Wang L, Yu X, et al. Materials Science & Engineering C: Mate-rials for Biological Applications, 2018, 82,299. 72 Tang L, Chen X, Wang L, et al. Polymer Chemistry, 2017, 8(32),4680. 73 Qu J, Zhao X, Liang Y, et al. Biomaterials, 2018, 183,185. 74 Xie W, Gao Q, Guo Z, et al. ACS Applied Materials & Interfaces, 2017, 9(39),33660. 75 Garza-Navarro M A, Torres-Castro A, Garcia-Gutierrez D I, et al. Journalof Physical Chemistry C, 2010, 114(41),17574. 76 Grondin P, Roubeau O, Castro M, et al. Langmuir: the ACS Journal of Surfaces and Colloids, 2010, 26(7),5184.