Advances on Application of Keratin Biomaterials in Wound Healing
SUN Xiaoxia1, BAO Yi1, PENG Qianrong2,3, CHEN Tingyu1, LU Xiaoluan1,YANG Min1
1 School of Medicine, Guizhou University, Guiyang 550025, China; 2 School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China; 3 Technology Center of China Tobacco Guizhou Industrial Co., Ltd., Guiyang 550009, China
Abstract: Wound healing is a complex, dynamic, and multistep process which can be affected in different conditions such as the type of wound, pathological conditions, and type of dressing.The ideal wound dressing is characterized by accelerated wound healing, preventing infection, restoration of skin structure and function, fascinating biomaterial and biodegradability and so on. Therefore, the research of wound dressing focus on the development of naturally-derived biomaterials, such as chitosan, gelatin, collagen, silk fibroin, keratin, etc. Keratin is one of proteins with good biocompatibility and degradability. What’s more, keratin contains cell binding motifs such as leucine-aspartic acid-valine (LDV), glutamic acid-aspartic acid-serine (EDS), and arginine-glycine-aspartic acid (RGD),which imitates the environment of the extracellular matrix to accelerate the adhesion and proliferation of fibroblasts. Furthermore, keratins actively participate in coagulation and aggregation of red blood cells. However, keratin has the disadvantages of brittleness, mechanical properties and poor processing properties. Usually, synthetic or natural polymer materials are added as plasticizers and cross-linking agents to form composite materials to improve these defects, such as polyvinyl alcohol,polylactic acid,chitosan and gelatin. These composite materials have been used to promote healing of wounds. This review offers a retrospection of the preparation of keratin and its composite hydrogels, scaffolds and membrane materials, and its research on wound healing. Especially skin transforming growth factors, antibacterials(mupirocin), bacteriostatic biomaterials(phenolic acid in natural plants)and antibacterial metal nano-materials (nano-silver, zinc oxide)are loaded into the keratin composite to obtain a multifunctional keratin wound dressing.It is used for acute and/or chronic wounds,such as diabetic foot ulcer, showing a unique advantage due to enhance the antibacterial effect and shortening the inflammation time of the wound. In addition, the prospect of keratin as a biomaterial in the field of medicine is discussed.
1 Chua A W C, Khoo Y C, Tan B K, et al. Burns & Trauma, 2016, 4(1), 3. 2 Sundaramurthi D, Krishnan U M, Sethuraman S. Polymer Reviews, 2014, 54(2), 348. 3 Mofazzal Jahromi M A, Sahandi Z P, Moosavi Basri S M, et al. Advanced Drug Delivery Reviews, 2017, 123, 33. 4 Boateng J S, Matthews K H, Stevens H N E, et al. Journal of Pharmaceutical Sciences, 2008, 97(8), 2892. 5 Siedenbiedel F, Tiller J C. Polymers,2012, 4(1), 46. 6 Borda L J, Macquhae F E, Kirsner R S. Current Dermatology Reports, 2016, 5(4), 1. 7 Landén Ning Xu, Li D, Mona Såthle, et al. Cellular and Molecular Life Sciences, 2016, 73(20), 3861. 8 Lin L, Chen J M, Wang H, et al. Materials Reports A:Review Papers, 2019, 33(1), 65(in Chinese). 林琳, 陈景民, 王会, 等. 材料导报:综述篇, 2019, 33(1), 65. 9 You J, Rafat M, Almeda D, et al. Biomaterials,2015, 57, 22. 10 Zhao X, Wu H, Guo B, et al. Biomaterials, 2017, 122, 34. 11 Li J, Xue B. Journal of Clinical Rehabilitative Tissue Engineering Research, 2013, 17(12), 2225(in Chinese). 李晶, 薛斌. 中国组织工程研究, 2013, 17(12), 2225. 12 Nicodemus G D, Bryant S J. Tissue Engineering Part B Reviews, 2008, 14(2), 149. 13 Lee H, Noh K, Sang C L, et al. Tissue Engineering & Regenerative Medicine, 2014, 11(4), 255. 14 Morais J M, Papadimitrakopoulos F, Burgess D J. The AAPS Journal, 2010, 12(2), 188. 15 Beighton E. Polymer, 1973, 14(2), 80. 16 Teresa K K, Justyna B. Waste Management, 2011, 31(8), 1689. 17 Shavandi A, Silva T H, Bekhit A A, et al. Biomaterials Science, 2017, 5(9), 1699. 18 Li P F, Hong Y, Chen S C, et al. Chinese Polymer Bulletin, 2013(6), 7 (in Chinese). 李鹏飞, 洪颖, 陈双春, 等. 高分子通报, 2013(6), 7. 19 Rouse J G, Van Dyke M E. Materials, 2010, 3(2), 999. 20 Wang Y, Zhang W, Yuan J. Materials Science and Engineering C, 2016, 59, 30. 21 Verma V, Verma P, Ray P, et al. Biomedical Materials, 2008, 3(2), 25007. 22 Burnett L R, Rahmany M B, Richter J R, et al. Biomaterials, 2013, 34(11), 2632. 23 Aboushwareb T, Eberli D, Ward C, et al. Journal of Biomedical Mate-rials Research Part B Applied Biomaterials, 2008, 90(1), 45. 24 Rahmany M B, Hantgan R R, Van D M. Biomaterials, 2013, 34(10), 2492. 25 Tang L, Sierra J O, Kelly R, et al. Experimental Dermatology, 2012, 21(6), 458. 26 Ullah F, Othman M B H, Javed F, et al. Materials Science and Enginee-ring C, 2015, 57, 414. 27 Anumolu S N S, Menjoge A R, Deshmukh M, et al. Biomaterials, 2011, 32(4), 1204. 28 Abdelrahman T, Newton H. Surgery (Oxford), 2011, 29(10), 491. 29 Hill P, Brantley H, Van Dyke M. Biomaterials, 2010, 31(4), 585. 30 De Guzman R C, Merrill M R, Richter J R, et al. Biomaterials, 2011, 32(32), 8205. 31 Bragulla H H, Homberger D G. Journal of Anatomy, 2010, 214(4), 516. 32 Silva R, Singh R, Sarker B, et al. Journal of Materials Chemistry B, 2014, 2(33), 5441. 33 Esparza Y, Bandara N, Ullah A, et al. Materials Science & Engineering C, 2018, 90, 446. 34 Wang J, Hao S, Luo T, et al. Colloids and surfaces B: Biointerfaces, 2016, 149, 341. 35 Poranki D, Whitener W, Howse S, et al. Journal of Biomaterials Applications, 2013, 29(1), 26. 36 Poranki D, Goodwin C, Van D M. BioMed Research International, 2016, 2016, 1. 37 Kakkar P, Madhan B. Materials Science and Engineering: C, 2016, 66, 178. 38 Park M, Shin H K, Kim B S, et al. Materials Science & Engineering C, 2015, 55, 88. 39 Han S, Ham T R, Haque S, et al. Acta Biomaterialia, 2015, 23, 201. 40 Raja S T K, Thiruselvi T, Sailakshmi G, et al. Biochimica et Biophysica Acta (BBA) - General Subjects, 2013, 1830(8), 4030. 41 Roy D C, Tomblyn S, Burmeister D M, et al. Advances in Wound Care, 2015, 4(8), 457. 42 Veerasubramanian P K, Thangavel P, Kannan R, et al. Colloids & Surfaces B Biointerfaces, 2018, 165, 92. 43 Ponrasu T, Veerasubramanian P K, Kannan R, et al. RSC Advances, 2018, 8(5), 2305. 44 Zhai M, Xu Y, Zhou B, et al. Journal of Photochemistry and Photobiology B: Biology, 2018, 180, 253. 45 Villanueva M E, Cuestas M L, Pérez C J, et al. Journal of Colloid and Interface Science, 2019, 536, 372. 46 Li W, Gao F, Kan J, et al. Colloids and Surfaces B: Biointerfaces, 2019, 175, 436. 47 Xu S, Sang L, Zhang Y, et al. Materials Science and Engineering:C-Materials for Biological Applications, 2013, 33(2), 648. 48 Tan H B, Wang F Y, Ding W, et al. Biomedical and Environmental Sciences, 2015, 28(3), 178. 49 Navone S, Pascucci L, Dossena M, et al. Stem Cell Research & Therapy, 2014, 5(1), 7. 50 Zoccola M, Aluigi A, Vineis C, et al. Biomacromolecules, 2008, 9(10), 2819. 51 Bhardwaj N, Sow W T, Devi D, et al. Integrative Biology, 2015, 7(1), 53. 52 Khajavi R, Rahimi M K, Abbasipour M, et al. Journal of Bioactive and Compatible Polymers, 2016, 31(1), 60. 53 Singaravelu S, Ramanathan G, Raja M D, et al. International Journal of Biological Macromolecules, 2016, 86, 810. 54 Gupta P, Nayak K K. International Journal of Biological Macromolecules, 2016, 85, 141. 55 Yamauchi K, Yamauchi A, Kusunoki T, et al. Journal of Biomedical Materials Research, 1996, 31(4), 439. 56 Borrelli M, Joepen N, Reichl S, et al. Biomaterials, 2015, 42, 112. 57 Aluigi A, Sotgiu G, Torreggiani A, et al. ACS Applied Materials & Interfaces, 2015, 7(31), 17416. 58 Katoh K, Shibayama M, Tanabe T, et al. Biomaterials, 2004, 25(12), 2265. 59 Yin X, Li F, He Y, et al. Biomaterials Science, 2013, 1(5), 528. 60 Zhang H, Yu Y, Cui S. Colloids & Surfaces A Physicochemical & Engineering Aspects, 2011, 384, 501. 61 Tanase C E, Spiridon I. Materials Science & Engineering C, 2014, 40, 242. 62 Thilagar S, Jothi N A, Kamaruddin M, et al. Journal of Biomedical Materials Research Part B Applied Biomaterials, 2010, 88B(1), 12. 63 Singaravelu S, Ramanathan G, Raja M D, et al. Materials Letters, 2015, 152, 90. 64 Wang Y, Li P, Xiang P, et al. Journal of Materials Chemistry B, 2016, 4(4), 635. 65 Yao C H, Lee C Y, Huang C H, et al. Materials Science & Engineering C Materials for Biological Applications, 2017, 79, 533. 66 Kim J W, Kim M J, Ki C S, et al. International Journal of Biological Macromolecules, 2017, 105, 541. 67 Shanmugasundaram O L, Ahmed K S Z, Sujatha K, et al. Materials Science & Engineering C, 2018, 92, 26. 68 Davidson A, Jina N H, Marsh C, et al. Eplasty, 2013, 13, e45. 69 Jull A, Wadham A, Bullen C, et al. BMJ Open, 2018, 8(2), e20319.