Synthetic Mechanism and Biomedical Application of Self-healing Hydrogel
LI Jin1, ZHAO Zinian1, LI Zhengzheng1,2,3,4, XUE Song1, ZHENG Zelin5
1 School of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin 300457; 2 State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433; 3 Tianjin Key Laboratory of Pulp & Paper, Tianjin University of Science & Technology, Tianjin 300457; 4 Tianjin Key Laboratory of Marine Resources and Chemistry, Tianjin University of Science & Technology, Tianjin 300457; 5 Nanjing Linhou Environmental Protection Technology Co., Ltd., Nanjing 210001
Abstract: Apolymer hydrogel is a soft material with high water content and generally composed of a polymer having a low degree of crosslinking. Hydrogels have been widely used in biomedical fields due to their advantages such as the structure and properties of hydrogels and the extremely high similarity of human soft tissues. Self-healing hydrogels are a new class of hydrogels that automatically restore their integrity and function after injury. Self-healing properties are important for extending the life of the material that is difficult to manufacture. To date, a variety of self-healing hydrogels have been synthesized by physical or dynamic chemical bonding. Physically crosslinked hydrogels are generally synthesized by multiple hydrogen bonding, host-guest interactions, ionic bonds, metal coordination, hydrophobic interactions, and supramolecular interactions. Chemical cross-linked self-healing hydrogels synthesized by dynamic chemical bonding have higher internal crosslink network strength than physical self-healing hydrogels, resulting in faster self-healing processes and higher mechanical strength. Therefore, dynamic chemical linkages such as imine bonds, hydrazide bonds and disulfide bonds, have been widely used to prepare self-healing hydrogels. As a new intelligent material, self-healing hydrogel has a wide application prospect in the field of medical biology. However, most hydrogels are three-dimensional systems of hydrophilic cross-linking in response to external stimuli. In vivo, once external mechanical forces or physiological erosion disrupts the structural integrity of the hydrogel, the functionality of the hydrogel is lost. Thus, the structural and functional integrity of the hydrogel during use may be affected by external mechanical forces or chemical attack, particularly in complex in vivo environments. In order to solve this problem, self-healing hydrogel with intrinsic self-healing ability can overcome internal and external environmental destructive factors that has been designed and developed. With self-healing capabilities, hydrogels can repair their damage and restore their original structure and perfor-mance with or without external stimuli, improving reliability and safety. Compared with traditional hydrogels, self-healing hydrogels have a longer service life and higher mechanical properties, which makes self-healing hydrogels have broader application prospects, especially in three-dimensional cell culture, tissue engineering and drug delivery. Since the research on self-healing hydrogels is still in its infancy, most of the research is still in the stage of exploring new self-healing hydrogel systems. In this review, the latest developments in self-healing hydrogels are highlighted, and the synthesis strategies of some self-healing hydrogels reported so far are summarized and analyzed, and the self-healing mechanism is described. Non-covalent bonds (physical bonds) include multiple hydrogen bonding, hydrophobic interactions, host-guest interactions, and dynamic covalent bonds (chemical bonds) include imine bonds and hydrazide bonds. In addition, the main factors affecting the self-healing properties of hydrogels and their extensive applications in biomedical fields such as tissue engineering and drug delivery were analyzed, which provide references for the preparation of novel self-healing hydrogels with superior performance.
作者简介: 李进,2017年6月毕业于烟台大学,获得工学学士学位。现为天津科技大学化工与材料学院硕士研究生,在李征征老师的指导下进行研究。目前主要研究领域为高分子智能水凝胶。li.z.z@tust.edu.cn。赵梓年,天津科技大学化工与材料学院副教授、硕士研究生导师。主持参与各类项目13项。主要从事高分子材料改性及加工技术,微孔及过滤材料,环境友好高分子材料的研究。参加天津市教委教改项目“计算机模拟高分子材料成型加工模式研究”,获得天津市教学成果二等奖。参编著作主要有:《塑料成型工艺学》《橡胶加工实用技术》。李征征,2014年2月毕业于韩国忠南大学,获得工学博士学位。现为天津科技大学化工与材料学院副研究员。目前主要研究领域为智能高分子水凝胶及其生物应用。These authors contributed equally to this work.
引用本文:
李进, 赵梓年, 李征征, 薛松, 郑泽邻. 自愈合水凝胶的合成机理及生物医学应用[J]. 材料导报, 2019, 33(19): 3328-3335.
LI Jin, ZHAO Zinian, LI Zhengzheng, XUE Song, ZHENG Zelin. Synthetic Mechanism and Biomedical Application of Self-healing Hydrogel. Materials Reports, 2019, 33(19): 3328-3335.
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2019, Vol. 33 
