一步法合成锶离子掺杂羟基磷灰石多孔微球

材料导报

2020, Vol. 34

Issue (Z1): 63-65

无机非金属及其复合材料

一步法合成锶离子掺杂羟基磷灰石多孔微球

齐美丽^1,2,3, 梅凤策¹, 黄浩¹, 崔凤坤¹

1 山东交通学院交通土建工程学院,济南250357;
2 山东大学材料科学与工程学院,济南250061;
3 山东百多安医疗器械股份有限公司,齐河251100

One-step Synthesis of Strontium-doped Porous Hydroxyapatite Microspheres

QI Meili^1,2,3, MEI Fengce¹, HUANG Hao¹, CUI Fengkun¹

1 School of Traffic and Civil Engineering, Shandong Jiaotong University, Ji'nan 250357, China;
2 School of Materials Science and Engineering, Shandong University, Ji'nan 250061, China;
3 Shandong Branden Medical Devices Co., Ltd, Qihe 251100, China

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摘要羟基磷灰石(HA)多孔微球具有优异的生物学性能和流动性,被广泛用作骨填充材料、药物缓释载体等,发展前景十分广阔。掺杂锶后的HA表现出更强的促成骨细胞分化活性且可改善HA的降解性,然而如何高效地得到大尺寸的锶掺杂HA多孔微球是一大挑战。鉴于此,本工作以无水SrCl₂·6H₂O和(NH₄)₂HPO₄的水溶液为原料,尿素为pH调节剂,L-谷氨酸(Glu)为生长调控剂,采用水热均相沉淀法一步合成了锶离子掺杂的羟基磷灰石多孔微球。重点研究了锶离子掺杂量对所得产物的物相和微观形貌的影响,以期为离子掺杂型HA多孔微球的制备提供实验依据。研究表明,当锶掺入量n(Sr)/n(Sr+Ca)=0.01时,水热180 ℃反应10 h,可以得到形貌较规则均一的锶离子掺杂HA多孔微球。

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关键词: 羟基磷灰石微球锶离子掺杂 L-谷氨酸水热均相沉淀

Abstract: Hydroxyapatite (HA) porous microspheres have excellent biological properties and fluid ability. They are widely used as bone filling materials and drug sustained-release carriers, showing a promising development prospect. Strontium-doped HA shows stronger osteogenic differentiation activity and improves the degradability of HA, however, how to obtain silver-doped porous HA microspheres with a large size is a big challenge. In this paper, strontium-doped porous HA microspheres was synthesized via hydrothermal homogeneous precipitation method with the aqueous solution of SrCl₂·6H₂O and (NH₄)₂HPO₄ as raw materials, urea as the pH regulator, and L-glutamic acid (Glu) as the growth regulator. Research were focused on effects of the amount of strontium ion doping on the phase and microstructure of the obtained products, in order to provide experimental basis for the preparation of ion doped porous HA microspheres. Results show that strontium ion doped porous HA microspheres with spherical and uniform morphology exist under the conditions of n(Sr)/n(Sr+Ca)=0.01 and hydrothermal treatment at 180 ℃ for 10 h.

Key words: hydroxyapatite microspheres strontium ion doping L-glutamic acid hydrothermal homogeneous precipitation

发布日期: 2020-07-01

ZTFLH:

TB321

基金资助: 国家自然科学基金(11947117);中国博士后科学基金资助项目(2019M660164);山东交通学院博士科研启动基金(BS50004919)

作者简介: 齐美丽,山东交通学院讲师,2018年6月毕业于山东大学,获得工程博士学位。2020年1月起在山东大学和山东百多安医疗器械股份有限公司开展博士后研究,主要从事生物医用材料领域的研究;崔凤坤,山东交通学院讲师, 2018年于长安大学获得工学博士学位。2016年受国家留学基金委资助赴纽约城市大学进行博士研究生联合培养,现担任山东省交通厅“北方冰冻海域长大桥梁建养实验室”科技部部长,山东省网络货运线上服务能力认定专家,Engineering Structures、Structure and Infrastructure Engineering等国际学术刊物审稿人。先后主持参与交通部、山东省、江苏省等科技项目及横向课题10余项,发表学术论文30余篇(SCI/EI收录10多篇),获授国家专利10余项。主要研究方向为大跨度桥梁结构基本理论及新材料力学性能分析等。

引用本文:

齐美丽, 梅凤策, 黄浩, 崔凤坤. 一步法合成锶离子掺杂羟基磷灰石多孔微球[J]. 材料导报, 2020, 34(Z1): 63-65.
QI Meili, MEI Fengce, HUANG Hao, CUI Fengkun. One-step Synthesis of Strontium-doped Porous Hydroxyapatite Microspheres. Materials Reports, 2020, 34(Z1): 63-65.

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http://www.mater-rep.com/CN/ 或 http://www.mater-rep.com/CN/Y2020/V34/IZ1/63

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