Abstract: With the frequent occurrence of various public health incidents, the development and application of various antibacterial products have been spawned. Antibacterial materials are classified according to the source of raw materials, including inorganic antibacterial materials, orga-nic antibacterial materials, natural antibacterial materials and synthetic antibacterial materials. As one of the most widely used inorganic metal ma-terials, stainless steel has made some progress in the application of antibacterial materials. There are two methods to obtain antibacterial properties of stainless steel: surface modification and alloying. However, the surface antibacterial stainless steel after abrasion is easy to lose the antibacterial effect, and the antibacterial ion utilization rate of alloy antibacterial stainless steel is low, which leads to unsatisfactory antibacterial effect of stainless steel. This urges intensive research endeavors to optimize antibacterial stainless steel fabrication process, aiming at improving durability and antibacterial efficiency, and expanding the scope of use of antibacterial stainless steel. In recent years, in order to improve the service life and antibacterial properties of antibacterial stainless steel, a variety of preparation technologies of antibacterial stainless steel have been developed. Adding antibacterial elements to stainless steel surface by deposition, penetration, implantation and spraying can increase the thickness of antibacterial layer and stabilize the antibacterial effect. At the same time, an appropriate amount of antibacterial metal elements added to stainless steel, after appropriate antibacterial treatment, can be continuously released in the me-dium, which make antibacterial rate greatly improve. In addition, in order to meet the use demand of antibacterial stainless steel in biomedical field and realize the organic combination of antibacterial property and biocompatibility, some biocompatible substances such as hydroxyapatite and poly (L-lactide-caprolactone) are often introduced into the surface, or use advanced preparation technology to control the release concentration of harmful metal ions, which can achieve the organic combination of antibacterial properties and biocompatibility. This paper summarizes the research status of various antibacterial stainless steels at home and abroad in the past decade. The antibacterial principles, characteristics of surface modified antibacterial stainless steel and alloy antibacterial stainless steel and the related manufacturing met-hods are introduced. In addition, due to the limitations of traditional manufacturing method, such as poor antibacterial durability, long preparation cycle, large material wear, and serious environmental pollution, additive manufacturing is considered as a new technique for producing antibacterial stainless steel. This developed technique exhibits the personalized customization, short time manufacturing, precision machining and other advantages to replace the above shortcomings of subtractive manufacturing. The application of additive manufacturing antibacterial materials in the medical care is also introduced in this paper.
1 Tian C L. World Latest Medicine Information, 2019, 19(65), 41 (in Chinese). 田承莉. 世界最新医学信息文摘, 2019, 19(65), 41. 2 Koller M F, Pletscher C, Scholz S M, et al. International Journal of Occupational and Environmental Health, 2016, 22(3), 193. 3 Saha R, Donofrio R S. Applied Microbiology and Biotechnology, 2012, 94(5), 1119. 4 Warshaw E M, Hagen S L, DeKoven J G, et al. Dermatitis, 2017, 28(3), 183. 5 Buckley S A, Evershed R P. Nature, 2001, 413(6858), 837. 6 Xiong J. Microstructure and antibacterial properties of austenitic stainless steel by copper ions implantation. Master's Thesis, Wuhan University of Science and Technology, China, 2004 (in Chinese). 熊娟. 铜离子注入奥氏体不锈钢中显微组织与抗菌性能的研究. 硕士学位论文, 武汉科技大学, 2004. 7 Qin H, Cao H L, Zhao Y C, et al. ACS Applied Materials & Interfaces, 2015, 7(20), 10785. 8 Alias R, Mahmoodian R, Genasan K, et al. Materials Science & Enginee-ring C-Materials for Biological Applications, 2020, 107, 110304. 9 Karabudak F, Yesildal R, Sukuroglu E E, et al. Arabian Journal for Science and Engineering, 2017, 42(6), 2329. 10 Wei C B. Preparation and properties of antibacterial TiN/Cu-Zn nanomultilayers and composite films by magnetron sputtering. Ph. D. Thesis, Harbin Institute of Technology, China, 2009 (in Chinese). 韦春贝. 磁控溅射TiN/Cu-Zn抗菌纳米多层膜与复合膜制备及性能. 博士学位论文, 哈尔滨工业大学, 2009. 11 Sheel D W, Brook L A, Ditta I B, et al. International Journal of Photoe-nergy, 2008, 2008, 168185. 12 Wang S S, Xu B F, Ni H W, et al. Heat Treatment of Metals, 2003 (2), 49 (in Chinese). 王世森, 许伯藩, 倪红卫,等. 金属热处理, 2003 (2), 49. 13 Li D, Xu B F, Ni H W, et al. Heat Treatment of Metals, 2005(2), 8 (in Chinese). 李东, 许伯藩, 倪红卫,等. 金属热处理, 2005 (2), 8. 14 Cowan M M, Abshire K Z, Houk S L, et al. Journal of Industrial Micro-biology & Biotechnology, 2003, 30(2), 102. 15 Galeano B, Korff E, Nicholson W L. Applied and Environmental Microbio-logy, 2003, 69(7), 4329. 16 Evans P, Sheel D W. Surface & Coatings Technology, 2007, 201(22), 9319. 17 Zou D N, Zhang W, Zhang S L, et al. Foundry Technology, 2005(11), 24 (in Chinese). 邹德宁, 张威, 张寿禄,等. 铸造技术, 2005 (11), 24. 18 Zhang W L, Song Q L, Fan Q Y, et al. Heat Treatment of Metals, 2015, 40(7), 107 (in Chinese). 张文莉, 宋群玲, 范启印,等. 金属热处理, 2015, 40(7), 107. 19 Hong I T, Koo C H. Materials Science and Engineering A-Structural Materials Properties Microstructure and Processing, 2005, 393(1), 213. 20 Ye D, Li J, Jiang W, et al. Materials & Design, 2012, 41, 16. 21 Vaynman S, Guico R S, Fine M E, et al. Metallurgical and Materials Transactions A, 1997, 28, 1274. 22 He H P. Wuhan Iron and Steel Corporation Technology, 1992(3), 33 (in Chinese). 何汉平. 武钢技术, 1992 (3), 33. 23 Zhang Z X. Microstructures and preoterties of copper(nitrogen)-bearing antibacterial stainless steels. Ph. D. Thesis, Shanghai Jiao Tong University, China, 2002(in Chinese). 张志霞. 含铜(氮)抗菌不锈钢的组织与性能研究. 博士学位论文, 上海交通大学, 2002. 24 Murcar-Evans B I, Cabral A D, Toutah K, et al. Analyst, 2017, 142(23), 4511. 25 Nan L, Liu Y Q, Lue M Q, et al. Journal of Materials Science-Materials in Medicine, 2008, 19(9), 3057. 26 Lu M Q, Chen S H, Dong J S, et al. Metallic Functional Materials, 2005(6), 10 (in Chinese). 吕曼祺, 陈四红, 董加胜,等. 金属功能材料, 2005(6), 10. 27 Bragg P D, Rainnie D J. Canadian Journal of Microbiology, 1974, 20(6), 883. 28 Yang K, Chen S H, Dong J S, et al. Metallic Functional Materials, 2005(6), 6 (in Chinese). 杨柯, 陈四红, 董加胜,等. 金属功能材料, 2005 (6), 6. 29 Trevors J T. Microbiological Sciences, 1987, 4(1), 29. 30 Kolmas J, Groszyk E, Kwiatkowska-Rozycka D. Biomed Research International, 2014, 2014, 178123. 31 Watson G K, Cummins D, Van der Ouderaa F J. Caries Research, 1991, 25(6), 431. 32 Raffi M, Mehrwan S, Bhatti T M, et al. Annals of Microbiology, 2010, 60(1), 75. 33 Feng Q L, Wu J, Chen G Q, et al. Journal of Biomedical Materials Research, 2000, 52(4), 662. 34 Kubota Y, Niwa C, Ohnuma T, et al. Journal of Photochemistry and Photobiology A-Chemistry, 2001, 141(2), 225. 35 Malafronte R D, Calvo E, James A A, et al. Insect Biochemistry and Molecular Biology, 2003, 33(1), 63. 36 Wang W J, Qian C F, Shen J Z, et al. Acta Microbiologica Sinica, 1999(5), 469 (in Chinese). 王文军, 钱传范, 申继忠,等. 微生物学报, 1999(5), 469. 37 Sharma A, Dutta R K, Roychowdhury A, et al. RSC Advances, 2016, 6(78), 74812. 38 Cho M, Chung H M, Choi W Y, et al. Applied and Environmental Microbiology, 2005, 71(1), 270. 39 Zhang L S, Wong K H, Yip H Y, et al. Environmental Science & Techno-logy, 2010, 44(4), 1392. 40 Li Y, Zhang W, Niu J F, et al. American Chemical Society Nano, 2012, 6(6), 5164. 41 Lopes F S, Oliveira J R, Milani J, et al. Materials Science & Engineering C-Materials for Biological Applications, 2017, 81, 373. 42 Wang G M, Feng H Q, Hu L S, et al. Nature Communications, 2018, 9, 2055. 43 Kang S J, Kim D H, Mishig-Ochir T, et al. Archives of Pharmacal Research, 2012, 35(3), 409. 44 Palffy R, Gardlik R, Behuliak M, et al. Molecular Medicine, 2009, 15(1), 51. 45 Pouny Y, Rapaport D, Mor A, et al. Biochemistry, 1992, 31(49), 12416. 46 Rozek A, Friedrich C L, Hancock R E. Biochemistry, 2000, 39(51), 15765. 47 Marchand C, Krajewski K, Lee H F, et al. Nucleic Acids Research, 2006, 34(18), 5157. 48 Castle M, Nazarian A, Yi S S, et al. The Journal of Biological Chemistry, 1999, 274(46), 32555. 49 Martinez B, Bottiger T, Schneider T, et al. Applied and Environmental Microbiology, 2008, 74(15), 4666. 50 Vincent P A, Morero R D. Current Medicinal Chemistry, 2009, 16(5), 538. 51 Cao P, Yuan C Q, Xiao J F, et al. Surface and Interface Analysis, 2018, 50(4), 516. 52 Duday D, Vreuls C, Moreno M, et al. Surface & Coatings Technology. 2013, 218, 152. 53 Anandkumar B, George R P, Philip J, et al. Analytica Chimica Acta, 2020, 1126, 38. 54 Caro A, Humblot V, Methivier C, et al. Journal of Physical Chemistry B, 2009, 113(7), 2101. 55 Dudchenko O Y, Pyeshkova V M, Soldatkin O O, et al. Nanoscale Research Letters, 2016, 11, 59. 56 Walker S L, Fourgialakis M, Cerezo B, et al. Journal of the Institute of Brewing. 2007, 113(1), 61. 57 Atta N F, Fekry A M, Hassaneen H M. International Journal of Hydrogen Energy, 2011, 36(11), 6462. 58 Jiang L. Preparation of surface antibacterial stainless steel by plasma alloying technology. Master's Thesis, Taiyuan University of Technology, China, 2012(in Chinese). 蒋立. 等离子合金化法制备表面抗菌不锈钢. 硕士学位论文, 太原理工大学, 2012. 59 Ni H W, Dan Z G, Xu B F, et al. Transactions of Materials and Heat Treatment, 2005(5), 42 (in Chinese). 倪红卫, 但智钢, 许伯藩,等. 材料热处理学报, 2005(5), 42. 60 Qin Z W, Wang L, Xu B F, et al. Materials Protection, 2006(8), 32 (in Chinese). 覃志伟, 王蕾, 许伯藩,等. 材料保护, 2006 (8), 32. 61 Wang L, Qin Z W, Ni H W, et al. Surface Technology, 2006(3), 39 (in Chinese). 王蕾, 覃志伟, 倪红卫,等. 表面技术, 2006(3), 39. 62 Wei C B, Gong C Z, Tian X B, et al. Chinese Journal of Vacuum Science and Technology, 2010, 30(1), 96 (in Chinese). 韦春贝, 巩春志, 田修波,等. 真空科学与技术学报, 2010, 30(1), 96. 63 Heinonen S, Nikkanen J P, Laakso J, et al. In: Proceedings of the 2nd International Conference on Competitive Materials and Technological Processes (IC-CMTP). Miskolc, Hungary, 2013, pp. 012064. 64 Batory D, Czerniak-Reczulska M, Kolodziejczyk L, et al. Applied Surface Science,2013, 275, 303. 65 Alias R, Mahmoodian R, Genasan K, et al. Materials Science & Enginee-ring C-Materials for Biological Applications. 2020, 107, 110304. 66 Echavarria A M, Rico P, Gomez Ribelles J L, et al. Vacuum, 2017, 145, 55. 67 Pradhaban G, Kaliaraj G S, Vishwakarma V. Progress in Biomaterials, 2014, 3(2), 123. 68 Wang M. Preparation of antibacterial film on stainless steel surface. Master's Thesis, Zhejiang University, China, 2003(in Chinese). 汪铭. 不锈钢表面抗菌薄膜的制备. 硕士学位论文, 浙江大学, 2003. 69 Gokcekaya O, Webster T J, Ueda K, et al. Materials Science & Enginee-ring C-Materials for Biological Applications, 2017, 77, 556. 70 Sivaraj D, Vijayalakshmi K. Journal of Analytical and Applied Pyrolysis, 2018, 134, 176. 71 Sivaraj D, Vijayalakshmi K. Ultrasonics Sonochemistry, 2019, 59, 104730. 72 Roopmani P, Satheesh S, Raj D C, et al. ACS Biomaterials Science & Engineering, 2019, 5(6), 2899. 73 Horkavcova D, Beloubkova T, Mizerova Z, et al. Ceramics-Silikaty, 2012, 56(4), 314. 74 Cao H L, Liu X Y, Meng F H, et al. Biomaterials, 2011, 32(3), 693. 75 Berger T J, Spadaro J A, Chapin S E, et al. Antimicrobial Agents and Chemotherapy, 1976, 9(2), 357. 76 Chiang W C, Tseng I S, Moller P, et al. Materials Chemistry and Phy-sics, 2010, 119(1), 123. 77 Xuan Y. Study of the silver precipitation behavior in silver-contain 304 austenitic stainless steel. Master's Thesis, Tsinghua University, China, 2014(in Chinese). 轩阳. 含银304奥氏体不锈钢中富银相析出行为研究. 硕士学位论文, 清华大学, 2014. 78 Xie Q. Microstructure and properties of copper-bearing ferritic stainless steel. Master's Thesis, Northeastern University, China, 2011(in Chinese). 解琼. 含铜铁素体不锈钢的组织与性能. 硕士学位论文, 东北大学, 2011. 79 Yang Z Y, Li W H, Lin S Y. Metallic Functional Materials, 2000(4), 1(in Chinese). 杨志勇, 李文辉, 林师焱. 金属功能材料, 2000(4), 1. 80 Zhang W, Li N, Xu Y G, et al. Heat Treatment of Metals, 2004 (8), 21 (in Chinese). 张伟, 李宁, 胥永刚,等. 金属热处理, 2004 (8), 21. 81 Zhang S, Yang C, Ren G, et al. Materials Technology, 2015, 30(B2), 126. 82 Zhang S Y. Study on the mechanism of the release of Cu ions and the biological effect of Cu-bearing stainless steel. Master's Thesis, University of Science and Technology Liaoning, China, 2014(in Chinese). 张书源. 含铜不锈钢铜离子释放机制研究及其生物学效应探索. 硕士学位论文, 辽宁科技大学, 2014. 83 Nan L, Yang K. Materials Technology, 2016, 31(1), 44. 84 Chen S H, Lv M Q, Zhang J D, et al. Acta Metallurgica Sinica, 2004(3), 314 (in Chinese). 陈四红, 吕曼祺, 张敬党,等. 金属学报, 2004(3), 314. 85 Nishiyabu K, Ishida M, Masai Y, et al. Joural of Korean Power Metallurgy Instit, 2002, 9(4), 227. 86 Yuan L, Ding S L, Wen C E. Bioactive Materials, 2019, 4, 56. 87 Zhang B, Huang Q R, Gao Y, et al. Journal of Wuhan University of Technology-Materials Science Edition, 2012, 27(4), 665. 88 Habijan T, Haberland C, Meier H, et al. Materials Science & Engineering C-Materials for Biological Applications, 2013, 33(1), 419. 89 Yang Y Q, Lu J B, Luo Z Y, et al. Rapid Prototyping Journal, 2012, 18(6), 482. 90 Bibb R, Eggbeer D, Williams R. Rapid Prototyping Journal, 2006, 12(2), 95. 91 Li R D, Liu J H, Shi Y S, et al. Journal of Materials Engineering and Performance, 2010, 19(5), 666. 92 Wehmöller M, Warnke P H, Zilian C, et al. In: Conference Record of the 19th International Congress and Exhibition on Computer Assisted Radiology and Surgery. Berlin, 2005. 93 Wang Y, Shen Y F, Wang Z Y, et al. Materials Letters, 2010, 64(6), 674. 94 Coello R, Charlett A, Wilson J, et al. Journal of Hospital Infection, 2005, 60(2), 93. 95 Agarwal A, Lin B, Wang J C, et al. Global Spine Journal, 2019, 9(1), 62. 96 Qing Y A, Li K S, Li D D, et al. Materials Science & Engineering C-Materials for Biological Applications, 2020, 108, 110430. 97 Hans M, Tamara J C, Mathews S, et al. Applied Surface Science, 2014, 320, 195. 98 McGaffey M, Zur Linden A, Bachynski N, et al. Plos One, 2019, 14(2), 0212995. 99 Hlinka J, Kraus M, Hajnys J, et al. Materials, 2020, 13(7), 13071527. 100 Kong D C, Ni X Q, Dong C F, et al. Materials & Design, 2018, 152, 88. 101 Wang Q, Ren L, Li X P, et al. Materials Science & Engineering C-Materials for Biological Applications, 2016, 68, 519. 102 Quan J F, Lin K J, Gu D D. Powder Technology, 2020, 364, 478. 103 Filters, Reusable Respirators with 3D Printed Metal, (n.d.). Available online: https://www.materialstoday.com/additive-manufacturing/news/reusable-respirators-with-3d-printed-metal-filters/ (accessed on 11 May 2020)