Research Progress of Titanium-based Hydroxyapatite Composites for Bone Implantation
XIE Fangxia1,2,*, HUANG Jiabing1, CAO Shu3, YANG Hao1, HE Xueming1,2
1 School of Mechanical Engineering, Jiangnan University, Wuxi 214122, Jiangsu, China 2 Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology, Wuxi 214122, Jiangsu, China 3 School of Mechanical Technology, Wuxi Institute of Technology, Wuxi 214121, Jiangsu, China
Abstract: Titanium and its alloys, which exhibit high strength, low modulus, excellent corrosion resistance and good biocompatibility, have been widely utilized in the field of biomedical sciences, especially as hard tissue replacement materials. However, due to the bioinert nature of titanium alloys, satisfactory osseointegration with human bone after their implantation is hard to achieve. Bioactive ceramics such as hydroxyapatite can induce deposition of osteoid apatite and cell adhesion, but their inherent brittleness limits their application in load-bearing. To improve the bioactivity of implants, the development of novel titanium-based hydroxyapatite composites as orthopedics materials has gained significant attention. Hydroxyapatite is surface coated on the titanium alloy to achieve a significantly improved bioactivity. This approach also has some shortco-mings:the resultant material exhibits low bonding strength and easy cracking of the coating. Therefore, the material needs to be improved in terms of coating composition, structure gradient, and post treatment. Although the metallurgical bonding between bioactive ceramics and metal matrix can be realized using powder metallurgy, it is difficult to accurately control and adjust the composition distribution and structural characteristics of materials. Natural bone has a gradient structure composed of porous cancellous bone and compact cortical bone. Matching these features is difficult for the orthopedic prostheses prepared by traditional powder metallurgy. The additive manufacturing (AM) technology can customize the implants through a layer-by-layer formation method, which is known to be highly advantageous in preparation of gradient composites. In recent years, the researchers have attempted to achieve compositional and structural gradients of the implants using AM to further improve their mechanical and biological properties. This paper summarizes research status of the titanium-based hydroxyapatite and discusses the solution strategies of the existing problems. Based on the microdroplet injection technology, we propose a new AM method for preparing multidimensionally gradient titanium-based hydroxyapatite composites to provide a reference for development of new functional biocomposites.
颉芳霞, 黄家兵, 曹澍, 杨豪, 何雪明. 钛合金羟基磷灰石骨植入复合材料的研究进展[J]. 材料导报, 2023, 37(13): 21070222-7.
XIE Fangxia, HUANG Jiabing, CAO Shu, YANG Hao, HE Xueming. Research Progress of Titanium-based Hydroxyapatite Composites for Bone Implantation. Materials Reports, 2023, 37(13): 21070222-7.
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2023, Vol. 37 
