碳纳米材料的抗菌性及在生物医学中的应用研究进展

材料导报

2020, Vol. 34

Issue (Z1): 53-57

无机非金属及其复合材料

碳纳米材料的抗菌性及在生物医学中的应用研究进展

张超¹, 张利², 刘兴华³, 陈琳³, 杨永珍³, 于世平⁴

1 山西医科大学附属白求恩医院,太原 030001;
2 山西白求恩医院,太原 030032;
3 太原理工大学新材料界面科学与工程教育部重点实验室,太原 030024;
4 山西医科大学第二附属医院,太原 030001

Research Advances in Antibacterial Properties and Applications in Biomedicine of Carbon Nanomaterials

ZHANG Chao¹, ZHANG Li², LIU Xinghua³, CHEN Lin³, YANG Yongzhen³, YU Shiping⁴

1 Bethune Hospital of Shanxi Province, Shanxi Medical University, Taiyuan 030001, China;
2 Bethune Hospital of Shanxi Province, Taiyuan 030032, China;
3 Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China;
4 Second Hospital of Shanxi Medical University, Taiyuan 030001, China

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摘要作为临床上所使用的主要抗菌药物,抗生素为人类的一些感染疾病提供了简单有效的治疗方法。然而抗生素的过度使用以及滥用逐渐造成了超级耐药菌的出现,使得细菌感染越来越难以治疗,对人类健康造成了严重的威胁。目前由耐药菌引起的细菌感染已是全球公共卫生面临的严峻挑战,因此,发展新型具有抗菌作用且不易产生耐药性的材料/药物势在必行。
在过去的十几年中,纳米技术的迅猛发展为抗菌治疗提供了很有前景的选择。通过对纳米材料与细菌相互作用机理的研究,发现了其与传统抗生素相比不易诱导细菌耐药的特点。按照材质来源的不同,纳米抗菌材料主要分为天然系、有机系及无机系。天然系包括植物来源和动物来源,受安全和生产等因素制约,无法实现大规模生产;有机系由于其稳定性差以及抗菌效果弱,在使用上受到很大的限制;无机系目前市场上主要以银系抗菌剂为主导,除易被氧化和团聚之外,其生物安全性还尚有争议。
在此背景下,碳纳米材料因其生产原料广泛、特殊的结构特征和理化性质,相对良好的生物相容性而备受关注。本文介绍的碳纳米材料主要包括碳纳米管、石墨烯材料、碳点及其衍生物,是目前应用非常广泛的一类纳米材料。现有的研究结果表明,碳纳米材料具有较高的抗菌活性和不易产生耐药性的特点,在抗菌领域中已逐渐得到应用。
本文就目前碳纳米材料的特性及抗菌机制的研究进行综述,介绍了碳纳米材料在医用抗菌领域中的应用现状,并对其在医用导尿管中的应用前景进行了展望,以期为解决导尿管相关性尿路感染提供依据。

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关键词: 耐药菌碳纳米材料抗菌医学应用

Abstract: As the main antibacterial agents used in clinic, antibiotics provide a simple and effective treatment for some infectious diseases of human. However, the overuse and abuse of antibiotics gradually lead to the emergence of super resistant bacteria, which makes bacterial infection more and more difficult to treat, and poses a serious threat to human health. At present, the bacterial infection caused by drug-resistant bacteria has been a serious challenge to the global public health. Therefore, it is imperative to develop new materials/drugs that have antibacterial effect and are not easy to produce drug resistance.
Rapid advances in nanotechnology have provided promising options for antimicrobial therapy over the past decade. By studying the mechanism of interaction between nanomaterials and bacteria, it is found that nanomaterials are less likely to induce bacterial resistance than traditional anti-biotics. According to the different sources of materials, nano-antibacterial materials are mainly divided into natural, organic and inorganic systems. Natural systems include plant and animal source, which can not realize mass production because of the restriction of safety, production and other factors. Due to their poor stability and weak antibacterial effect, organic systems are greatly restricted in use. At present, the inorganic systems are mainly dominated by silver-based antibacterial agents. In addition to being easily oxidized and agglomerated, their biological safety is still controversial.
Under this background, carbon nanomaterials have attracted much attention due to their wide range of raw materials, special structural characteristics, physical and chemical properties, and relatively good biocompatibility. The carbon nanomaterials introduced in this paper mainly include carbon nanotubes, graphene materials, carbon dots and their derivatives, which are widely used at present. The existing research results show that carbon nanomaterials have high antibacterial activity and are not easy to produce drug resistance, and have been gradually applied in the field of antibacterial.
In this paper, the characteristics and antibacterial mechanism of carbon nanomaterials are reviewed. The application status of carbon nanomaterials in the field of medical antibacterial is introduced, and the application prospect of carbon nanomaterials in medical catheter is prospected,which can provide a reference for solving urinary tract infections associated with catheters.

Key words: drug-resistance bacteria carbon nanomaterials antibacterial medical application

发布日期: 2020-07-01

ZTFLH:

TB34

基金资助: 山西省重点研发计划项目(201703D32015-4);山西省优秀人才科技创新项目(201805D211001)

作者简介: 张超,2018年7月毕业于山西医科大学,获得临床医学学士学位。现为山西医科大学附属白求恩医院硕士研究生,在张利教授和杨永珍教授的指导下进行研究。目前主要研究领域为碳纳米材料在抗菌导管中的应用;张利,山西省白求恩医院副主任医师,硕士研究生导师。2001年7月在山西医科大学取得硕士学位,2012年11月在太原理工大学材料学院取得博士学位。近年来,在抗菌纳米材料及抗菌导管领域发表论文多篇,并先后承担省市课题6项,获国家发明专利3项,实用新型专利3项。

引用本文:

张超, 张利, 刘兴华, 陈琳, 杨永珍, 于世平. 碳纳米材料的抗菌性及在生物医学中的应用研究进展[J]. 材料导报, 2020, 34(Z1): 53-57.
ZHANG Chao, ZHANG Li, LIU Xinghua, CHEN Lin, YANG Yongzhen, YU Shiping. Research Advances in Antibacterial Properties and Applications in Biomedicine of Carbon Nanomaterials. Materials Reports, 2020, 34(Z1): 53-57.

链接本文:

http://www.mater-rep.com/CN/ 或 http://www.mater-rep.com/CN/Y2020/V34/IZ1/53

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