转铁蛋白在纳米靶向药物递送体系的应用

材料导报

2021, Vol. 35

Issue (z2): 501-507

高分子与聚合物基复合材料

转铁蛋白在纳米靶向药物递送体系的应用

义水灵, 熊向源

江西科技师范大学生命科学学院,南昌 330013

Application of Transferrin in Nano-sized Targeted Drug Delivery Systems

YI Shuiling, XIONG Xiangyuan

School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China

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摘要纳米靶向药物递送体系(Targeting drug delivery system,TDDS)是诊断和治疗癌症的一种有效方法,因其在特定的肿瘤部位高度累积,且药物毒副作用小和生物利用度高,而受到广泛关注。转铁蛋白受体在多数癌细胞表面过度表达,但在正常细胞表面低表达或未表达,与转铁蛋白配体具有高度的亲和力。转铁蛋白偶联的TDDS具有靶向性强、毒副小等优点。本文主要论述转铁蛋白受体介导TDDS的靶向作用机制、常见转铁蛋白功能化纳米药物递送载体的类型以及三类仍处于临床前研究的转铁蛋白功能化纳米TDDS,旨在为肿瘤靶向给药的进一步研究提供参考和新思路。

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关键词: 靶向药物递送体系转铁蛋白靶向药物载体纳米粒子

Abstract: Nano-sized targeted drug delivery systems (TDDS) are the effective method for the diagnosis and treatment of cancer, which is highly accumulated in specific tumor sites, with low side effects and high bioavailability, so it has attracted wide attention. Transferrin receptors are overexpressed on the surface of most cancer cells, but low or not expressed on the surface of normal cells, and have a high affinity with transferrin ligand. Transferrin-coupled TDDS have the advantages of strong targeting and less toxic side effects. This paper mainly discusses the targeting mechanism of TDDS mediated by transferrin receptor, the types of common transferrin functionalized nano-sized targeted drug delivery carriers and three kinds of transferrin functionalized nano-sized TDDS which are still in preclinical research, so as to provide reference and new ideas for further research of TDDS.

Key words: targeted drug delivery system transferrin targeted drug carrier nanoparticles

发布日期: 2021-12-09

ZTFLH:	TB324
	R73

基金资助: 国家自然科学基金(21664007)

通讯作者: xy.xiong@qq.com

作者简介: 义水灵,2020 年毕业于湖南医药学院医学检验技术。现为江西科技师范大学生命科学学院硕士研究生,在熊向源教授的指导下进行研究。目前主要研究方向为高分子生物医药材料,转铁蛋白靶向纳米药物的合成及表征,以及相关细胞毒性和药物摄取等。
熊向源,江西科技师范大学教授,江西省主要学科学术和技术带头人,被评为2009年江西省百千万人才工程人选,2010年度南昌市劳动模范(先进工作者)。2001年于北京大学获高分子化学与物理硕士学位,同年8月前往新加坡南洋理工大学攻读博士学位,于2005年5月获博士学位,其中2004年8月至2005年3月任新加坡-美国麻省理工联盟研究助理。2005年加入江西科技师范学院生命科学学院工作,同年12月被评为教授。主要从事纳米级高分子药物载体的研究,包括生物相容性和生物可降解性嵌段共聚物的可控合成及表征,高分子纳米粒子在水中的聚集形态和大小,纳米粒子在生物医药领域的应用研究,尤其是可控释放体系、靶向释放体系等。在Journal of ControlledRelease、Nanomedicine等期刊上发表了20余篇SCI论文。获得2007—2008年度江西省高等学校科技成果奖二等奖,2009年度江西省自然科学奖三等奖。

引用本文:

义水灵, 熊向源. 转铁蛋白在纳米靶向药物递送体系的应用[J]. 材料导报, 2021, 35(z2): 501-507.
YI Shuiling, XIONG Xiangyuan. Application of Transferrin in Nano-sized Targeted Drug Delivery Systems. Materials Reports, 2021, 35(z2): 501-507.

链接本文:

http://www.mater-rep.com/CN/ 或 http://www.mater-rep.com/CN/Y2021/V35/Iz2/501

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