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材料导报  2021, Vol. 35 Issue (13): 13186-13197    https://doi.org/10.11896/cldb.20010129
  高分子与聚合物基复合材料 |
蛋白质药物胞内递送纳米载体的研究进展
姜佳敏, 李盼盼, 方斌, 杜威, 柏桦*, 彭勃, 李林*
西北工业大学,西安生物医学材料与工程研究院,西安柔性电子研究院,柔性电子前沿科学中心,西安 710072
Recent Progress in Nanocarriers for Intracellular Protein Drug Delivery
JIANG Jiamin, LI Panpan, FANG Bin, DU Wei, BAI Hua*, PENG Bo, LI Lin
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an 710072, China
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摘要 癌症、心脑血管疾病、中枢神经疾病已成为威胁人类健康的三大杀手。传统的小分子药物在治疗过程中由于存在特异性差等缺点,很容易对除病灶细胞以外的正常细胞造成影响,从而对机体产生毒副作用。蛋白质作为药物相较于传统小分子药物而言具有更高的生物相容性和特异性。然而,特殊的分子结构和生化性质使得蛋白质药物很容易在复杂的生物环境中因受影响而失活,从而限制了蛋白质药物在生物医学上的应用。因此,寻找理想的药物递送系统来弥补药物自身不足,帮助药物在病灶区顺利发挥作用显得尤为重要。为了解决这一问题,业内开发了各种具有不同功能的纳米药物载体,如聚合物纳米载体、脂质纳米载体、无机纳米载体等。本文全面总结了基于不同载体的蛋白质药物细胞内递送的策略,详细讨论了这些材料的设计方法、作用机制以及在活细胞/体内的潜在应用,最后对新一代载药系统的应用前景进行了展望。
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姜佳敏
李盼盼
方斌
杜威
柏桦
彭勃
李林
关键词:  纳米载体  靶向特异性  药物递送  疾病治疗    
Abstract: Nowadays, many diseases like cancer, cardiovascular, cerebrovascular diseases, and central nervous system pathology are becoming more and more important issues that can endanger human health. Due to the low-specificity, the traditional small-molecule drugs can easily affect normal cells other than tumor cells during the treatment process, thereby causing toxic and side effects on the body. Protein as a drug has higher biocompatibility and specificity compared with traditional small molecule drugs. However, its special molecular structure and biochemical properties make protein drugs easily inactivated in complex biological environments. These problems limit the application of protein drugs in biomedicine. Therefore, it is particularly important to find an ideal drug delivery system to make up for the deficiencies of the drug itself, and to help the drug work effectively in the lesion area. In order to solve this problem, the industry has developed various nano drug carriers with different functions, such as polymer nano carriers, lipid nano carriers, inorganic nano carriers, etc. This review comprehensively summarizes the intracellular delivery strategies of protein drugs based on different carriers. What's more, the materials' design methods, mechanism of action, and potential applications in living or in vivo will be discussed in detail. Finally, we prospected the application of the new-generation drug delivery system in the field.
Key words:  nanocarrier    targeted specificity    drug delivery    disease therapeutics
               出版日期:  2021-07-10      发布日期:  2021-07-14
ZTFLH:  R318.08  
基金资助: 国家自然科学基金(81672508);陕西省自然科学基础研究计划资助项目(2019JM-016;2019JM-130)
作者简介:  姜佳敏,2019年6月毕业于湘潭大学,获得理学学士学位。现为西北工业大学化学与化工学院硕士研究生,在李林教授负责的有机/生物医学光子学课题组进行研究。目前主要研究方向为荧光染料的蛋白调控。
柏桦,西北工业大学柔性电子研究院助理教授,2011年博士毕业于中国人民解放军第四军医大学,主要从事线粒体代谢调控、氧化还原信号与相关疾病的研究。发表及合作发表SCI论文20余篇,其中第一/通讯作者10篇。担任全国活性氧生物学效应专业委员会常委兼秘书长、陕西省预防医学会营养与食品安全专业委员会委员、中国生物物理学会自由基医学专业委员会青年委员。
李林,西北工业大学柔性电子研究院教授、博士研究生导师。2009年7月博士毕业于安徽大学化学化工学院,2009—2014年在新加坡国立大学化学系(Yao Shao Q. 教授课题组)从事化学生物学相关的博士后研究工作。2014年全职回国并入选“青年千人计划“,现任柔性电子研究院生物电子所所长、有机/生物医学光子学课题组负责人,主要从事线粒体特异性检测与调控研究。近年来,相继在 Accounts of Chemical Research、 Nature Communications、 Journal of the American Chemical Society、 Angewandte Chemie International Edition等国际期刊上发表研究论文170余篇,其中第一/通讯作者77篇。
引用本文:    
姜佳敏, 李盼盼, 方斌, 杜威, 柏桦, 彭勃, 李林. 蛋白质药物胞内递送纳米载体的研究进展[J]. 材料导报, 2021, 35(13): 13186-13197.
JIANG Jiamin, LI Panpan, FANG Bin, DU Wei, BAI Hua, PENG Bo, LI Lin. Recent Progress in Nanocarriers for Intracellular Protein Drug Delivery. Materials Reports, 2021, 35(13): 13186-13197.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.20010129  或          http://www.mater-rep.com/CN/Y2021/V35/I13/13186
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