Reactive Oxygen Species Activated Polymeric Drug Nanocarriers for Combined Photodynamic-Chemotherapy of Cancer
SONG Pengyu, DENG Yongyan, HAN Haijie, JIN Qiao
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
Abstract: In tumor therapy, photodynamic therapy (PDT) has attracted more and more attention. In order to address the limitations of photosensitizer skin photosensitivity and molecular aggregation that can reduce photodynamic effects, the amphiphilic block copolymer containing reactive oxygen (ROS)-sensitive keto thiol-linked DOX was synthesized. The photosensitizer dihydroporphyrin e6 (Ce6) was physically encapsulated to construct the co-delivered nanocarrier which can be activated by intracellular ROS. The nanocarrier itself was in the inactive state, showing a weak photodynamic effect and low cytotoxicity. However, at high concentrations within the tumour cells under the action of ROS, ketone mercaptan linkage would be cleaved and DOX would be released, resulting in the disassembly of the micelles and release of Ce6. Ce6 and DOX could be released effectively in high ROS concentration. Compared to the nanocarriers that were not sensitive to intracellular ROS, the ROS sensitive nanocarriers could be readily activated after internalization. Therefore, more ROS could be generated after light irradiation. Moreover, the intracellular release of Ce6 and DOX was very beneficial to inhibit the proliferation of cancer cells. The co-delivered nanocarriers showed higher cytotoxic effect and inhibited the proliferation of cancer cells effectively compared with the single treatment of DOX and Ce6.
宋鹏宇, 邓永岩, 韩海杰, 金桥. 活性氧可激活的聚合物纳米载体用于光动力-化疗联合治疗的研究[J]. 材料导报, 2020, 34(10): 10166-10170.
SONG Pengyu, DENG Yongyan, HAN Haijie, JIN Qiao. Reactive Oxygen Species Activated Polymeric Drug Nanocarriers for Combined Photodynamic-Chemotherapy of Cancer. Materials Reports, 2020, 34(10): 10166-10170.
1 Hu Z A, Xie Y L, Wang Y X, et al. Journal of Physical Chemistry C, 2009, 113(28),12502. 2 Bazarbashi S, Elbassiouni M, Abdelsalam M, et al. Journal of Surgical Oncology, 2010, 98(3),167. 3 Nicolescu N, Molnár G, Iancu C, et al. Chirurgia, 2011, 106(1),33. 4 Kortmann R D, Timmermann B, Taylor R E, et al. Strahlentherapie Und Onkologie, 2003, 179(9),585. 5 Kim J W, Jang J Y, Chang Y W. World Journal of Gastroenterology, 2015, 21(27),8358. 6 Agostinis P, Berg K, Cengel K A, et al. CA: A Cancer Journal for Clinicians, 2011,61(4),250. 7 Liu Y, Ban D X, Ma C, et al. Journal of Biomedical Nanotechnology, 2016, 12(11),2063. 8 Qin S Y, Zhang A Q, Zhang X Z. Small, 2018, 14(45), 1802417. 9 Chen D G,Xiong X Y,Gong Y C,et al.Material Reports A:Review Papers, 2019 33(2),517(in Chinese). 陈道鸽, 熊向源, 龚妍春, 等.材料导报:综述篇, 2019 33(2),517. 10 Jin Q, Deng Y, Chen X, et al. ACS Nano, 2019, 13, 954. 11 Wang Y, Deng Y, Luo H, et al. ACS Nano, 2017, 11(12), 12134. 12 Deng Y, Käfer F, Chen T, et al. Small, 2018, 14(37), 1802420. 13 Hartshorn C M, Bradbury M S, Lanza G M, et al. ACS Nano, 2017, 12(1),24. 14 Deng Y, Jia F, Chen S, et al. Biomaterials, 2018, 187, 55. 15 Wu J, Han H, Jin Q, et al. ACS Applied Materials & Interfaces, 2017, 9(17), 14596. 16 Du J Z, Li H J, Wang J. Accounts of Chemical Research, 2018, 51(11), 2848. 17 Lu A,Hou Y,Wu Z,et al. Acta Polymerica Sinica, 2016 (10), 1400(in Chinese). 陆爱菁, 侯宇, 吴正中, 等.高分子学报, 2016 (10), 1400. 18 Cao Z, Ma Y, Sun C, et al. Chemistry of Materials, 2018, 30(2),517. 19 Tong H, Chen Y, Li Z,et al. Small, 2016, 12(45),6223. 20 Han H, Valdepeérez D, Jin Q, et al. ACS Nano, 2017, 11(2),1281. 21 Elegbede A I, Banerjee J, Hanson A J, et al. Journal of the American Chemical Society, 2008, 130(32), 10633. 22 Kelley E G, Albert J N, Sullivan M O, et al. Chemical Society Reviews2013, 42, 7057. 23 Xiong M H, Bao Y, Du X J, et al. ACS Nano, 2013, 7(12),10636. 24 Lei Q, Wang S B, Hu J J, et al. ACS Nano, 2017, 11(7), 7201. 25 Wu J, Lin Y, Li H, et al. Journal of Colloid and Interface Science, 2017, 485, 251. 26 Li J, Sun C, Tao W, et al. Biomaterials, 2018, 170,147. 27 Hu J J, Lei Q, Peng M Y, et al. Biomaterials, 2017, 128, 136.
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2020, Vol. 34 
