Abstract: Diethyl methacrylate (DEAEMA), methyl methacrylate (MMA) and 4-acrylloxybenzophenone (ABP) were used as monomers to prepare a series of photo-initiable cross-linked polymer P(DEAEMA-co-MMA-co-ABP) by free radical polymerization and then the synthesized copolymer was spun to be nanofibers. Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic field (1H NMR), gel penetration chromatography (GPC), thermogravimetric analysis (TGA) were used to test and characterize the chemical composition, structure and properties of the copolymers. The morphology of the nanofibers was characterized by optical and scanning electron microscopy (SEM), and the pH responsiveness of both synthesized copolymer and the cross-linked nanofibers were studied via changing the pH of solutions. The results show that the copolymer with 80∶10∶10 molar ratio of DEAEMA/MMA/ABP exhibits sensitive pH response, and the nanofibers with uniform morphology can be spun under the conditions with volume ratio of DMF/THF at 1∶9 and mass concentration of copolymer at 40wt%. Moreover, the cross-linked 3D nanofibrous mats have the properties of reversible swelling and contraction in acid-base solutions. Such nanofibrous mats can be used in the fields of controlled drug release and tissue carrier.
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