Promising Biomedical Material Based on Collagen Composite ElectrospunNanofibers: a Review
HUANG Yanping1,2, DAN Nianhua1,2, DAN Weihua1,2
1 National Engineering Laboratory for Clean Technology of Leather Manufacture, College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu 610065; 2 The Research Center of Biomedicine Engineering of Sichuan University, Chengdu 610065
Abstract: Collagen with triple helix structure is considered to be a major component of the extracellular matrix, which is widely used in the field of biomedical materials due to its unique characteristics, including low immunogenicity and biodegradability. However, there are intramolecular, intermolecular hydrogen bonds, ionic bonds, van der Waals forces, and hydrophobic bonds between polar groups and non-polar groups inside the collagen, hence it can only be dissolved in limited range of solvents, such as dilute acetic acid, hexafluoroisopropanol and trifluoroethanol, ionic liquid, making it difficult to fabricate collagen nanofibers. Fluoroalcohol is the most commonly used solvent for collagen electrospinning, but it is also prone to destroy the triple helix structure of collagen to some extent. In addition, the lack of intermolecular and intramolecular crosslinking results in the unsatisfactory properties of collagen electrospun nanofibers, e.g. low mechanical strength and high degradation tendency. In order to improve the performance of collagen nanofibers, researchers have invested considerable efforts in the co-electrospinning of collagen and organic polymer composites. The cooperation of the two materials significantly improves the strength of collagen nanofibers, meanwhile, endows them with other properties of organic polymers (elasticity, antibacterial, degradation resistance, etc.), which further extend their application in the biomedical field. Natural polymers derived from animals and plants have good biocompatibility, and their natural biological structure is distinctive to synthetic polymers. Nevertheless, natural polymers are mostly polyelectrolytes, making it more difficult to synthesize compared to the synthetic polymers. The composite nanomedical fibers prepared by combining collagen with natural polymers can not only retain the biocompatibility of natural polymers, but also get improved in the mechanical properties of collagen electrospun membranes or obtain other functionalities. In this regard, the blending of collagen with silk fibroin, chitosan, elastin and hyaluronic acid has received major attention. Synthetic polymer has fine physical properties, certain biocompatibility, good processability, and excellent repeatability, thus it can be blended with collagen to improve the spinnability of collagen and the mechanical properties of fiber membranes. The obtained composite membranes were found to exhibit promising potential in the field of tissue engineering scaffolds and drug sustained release requiring long-term implantation. Commonly used synthetic polymers blended with collagen are polycaprolactone, polyethylene oxide, polyurethane, polylactic acid-glycolic acid copolymer, poly(L-lactic acid-co-ε-caprolactone), polyvinyl alcohol. This review summarizes the global research status of collagen composite nanofibers fabricated by electrospinning method in recent years, focusing on the collagen/natural organic polymer composite nanofibers and the collagen/synthetic organic polymer composite nanofibers. It also provides an outlook over the future prospect.
作者简介: 黄艳萍,2016年毕业于四川大学,获得硕士学位。现为四川大学轻纺与食品学院博士研究生,在但卫华教授的指导下进行研究。目前主要研究领域为生物质医用材料。但卫华,四川大学博士,教授,博士研究生导师。享受国务院政府特殊津贴专家、四川省学术技术带头人。现任四川大学生物质与皮革工程系教授、四川大学生物质工程研究所所长、四川大学生物医学工程技术研究中心生物质医用材料研究室主任。《生物医学工程与临床》杂志编委、Journal of Applied Science、Biomaterials、《功能材料》审稿专家。danweihua_scu@126.com
引用本文:
黄艳萍, 但年华, 但卫华. 静电纺丝制备胶原基复合纳米医用纤维的研究进展[J]. 材料导报, 2019, 33(19): 3322-3327.
HUANG Yanping, DAN Nianhua, DAN Weihua. Promising Biomedical Material Based on Collagen Composite ElectrospunNanofibers: a Review. Materials Reports, 2019, 33(19): 3322-3327.
Anton F. U.S. patent 1975,504.1934-10-2.2 Kong B, Mi S. Materials,2016,9(8),614.3 Sell S A, McClure M J, Garg K, et al. Advanced Drug Delivery Reviews,2009,61(12),1007.4 Fullana M J, Wnek G E. Drug Delivery and Translational Research,2012,2(5),313.5 Zheng W, Zhang W, Jiang X. Advanced Engineering Materials,2010,12(9),B451.6 Zhan H Y, Li Z Q, Cai Z S. Fiber chemistry and physics, Beijing Science Press, China,2005(in Chinese).詹怀宇,李志强,蔡再生.纤维化学与物理,科学出版社,2005.7 Li H, Zheng G X, Wang Q F, et al. China Leather,2006,35(3),27(in Chinese)李贺,郑庚修,王秋芬,等.中国皮革,2006,35(3),27.8 Buttafoco L, Kolkman N, Engbers-Buijtenhuijs P, et al. Biomaterials,2006,27(5),724.9 Ma K, Chan C K, Liao S, et al. Biomaterials,2008,29(13),2096.10 Li M, Mondrinos M J, Gandhi M R, et al. Biomaterials,2005,26(30),5999.11 Zhong S, Teo W E, Zhu X, et al. Biomacromolecules,2005,6(6),2998.12 Schofer M D, Boudriot U, Wack C, et al. Journal of Materials Science: Materials in Medicine,2009,20(3),767.13 Ye J, Shi X, Chen X, et al. Journal of Materials Chemistry B,2014,2(27),4226.14 Kim S H, Nam Y S, Lee T S, et al. Polymer,2003,35(2),18.15 Vepari C, Kaplan D L. Progress in Polymer Science,2007,32(8),991.16 Ma R L, Zhao Y M. Advanced Textile Technology,2012,20(2),1(in Chinese).马瑞丽,赵亚梅.现代纺织技术,2012,20(2),1.17 Wang X L, Dai W G, He J X, et al. Journal of Materials Science and Engineering,2012,30(2),287(in Chinese).王晓磊,戴卫国,何建新,等.材料科学与工程学报,2012,30(2),287.18 Ohgo K, Zhao C, Kobayashi M, et al. Polymer,2003,44(3),841.19 Zhou J, Cao C, Ma X, et al. International Journal of Biological Macromolecules,2010,47(4),514.20 Zhu B F, Li W, Lewis R V, et al. Biomacromolecules,2015,16(1),202.21 Khor E, Lim L Y. Biomaterials,2003,24(13),2339.22 Chen Z G, Wang P W, Wei B, et al. Acta Biomaterialia,2010,6(2),372.23 Chang D C, Wang X L, Hou X, et al. Journal of Biomedical Enginee-ring,2008(6),1454(in Chinese).常德才,王晓丽,侯信,等.生物医学工程学杂志,2008(6),1454.24 Robert L, Hornebeck W. Elastin and elastases, CRC Press,1989.25 Boland E D, Matthews J A, Pawlowski K J, et al. Frontiers in Bioscience,2004,9(1422),e32.26 Shi X. Development and performance studies of chitosan modified collagen-hyaluronic acid composite electrospinning film with biomimetic micro-nano structure of denuded amniotic membrane. Ph.D. Thesis, Zhejiang university, China,2013(in Chinese).石鑫.仿去上皮羊膜微纳结构壳聚糖改性胶原—透明质酸复合电纺膜的研制及其性能研究.博士学位论文,浙江大学,2013.27 Kim T G, Chung H J, Park T G. Acta Biomaterialia,2008,4(6),1611.28 Chen Y, Zeng D, Ding L, et al. Chinese Journal of Biochemistry and Molecular Biology,2015(1),72(in Chinese).陈焱,曾迪,丁璐,等.中国生物化学与分子生物学报,2015(1),72.29 Ma H. Biocompatibility of polycaprolactone/chitosan electropun nanofiber scaffold and poly(lactic-co-glycolic acid)/chitosan elcetrospun nanofiber scaffold cultured with schwann cells. Master’s Thesis, Dalian Medical University, China,2014(in Chinese).马昊.聚己内酯-壳聚糖静电纺丝纳米纤维支架与聚乳酸-羟基乙酸-壳聚糖静电纺丝纳米纤维支架同雪旺细胞的生物相容性研究.硕士学位论文,大连医科大学,2014.30 Peng L L, Yang Q, Shen X Y, et al. Synthetic Fiber in China,2008,37(11),25(in Chinese).彭兰兰,杨庆,沈新元,等.合成纤维,2008,37(11),25.31 Yu H, Jia Y, Yao C, et al. International Journal of Pharmaceutics,2014,469(1),17.32 Fang R, Zhang E, Xu L, et al. Journal of Nanoscience and Nanotechnology,2010,10(11),7747.33 Dulnik J, Denis P, Sajkiewicz P, et al. Polymer Degradation and Stability,2016,130,10.34 Zhao X Z, Gao J, Wang L, et al. Melliand China,2015(11),55(in Chinese).赵新哲,高晶,王璐,等.国际纺织导报,2015(11),55.35 Chen Y, Guo Y Y, Gao J, et al. Journal of Donghua University, Natural Sciences,2014(6),739(in Chinese).陈燕,郭蕴仪,高晶,等.东华大学学报(自然科学版),2014(6),739.36 Phipps M C, Clem W C, Catledge S A, et al. PLOS One,2011,6(2),e16813.37 Phipps M C, Clem W C, Grunda J M, et al. Biomaterials,2012,33(2),524.38 Chen R, Huang C, Ke Q F, et al. Colloids and Surfaces B: Biointerfaces,2010,79(2),315.39 Wang S, Banerjee A, Matarlo B, et al. Bioinspired, Biomimetic and Nanobiomaterials,2012,1(4),202.40 Goncalves F, Bentini R, Burrows M C, et al. Materials,2015,8(2),408.41 Zhang M, Li Z Q, Liu L H, et al. Journal of Nanomaterials,DOI:10.1155/2016/9159364.42 Liu S J, Kau Y C, Chou C Y, et al. Journal of Membrane Science,2010,355(1-2),53.43 Chen D W, Hsu Y H, Liao J Y, et al. International Journal of Pharmaceutics,2012,430(1-2),335.44 Ouyang Y M, Huang C, Zhu Y, et al. Journal of Biomedical Nanotech-nology,2013,9(6),931.45 Kim W J, Shin Y M, Park J S, et al. Polymer.-Korea,2012,36(2),124.46 He X M, Fu W, Wang H, et al. Chinese Journal of Clinicians (Electronic edition),2012(22),7095(in Chinese).何晓敏,付炜,王浩,等.中华临床医师杂志(电子版),2012(22),7095.47 Qu J J, Dan W H, Zeng R, et al. Leather Science and Engineering,2006(2),14(in Chinese).曲健健,但卫华,曾睿,等.皮革科学与工程,2006(2),14.48 Xiao S W, Dan N H, Ma W J, et al. Materials Review B: Research Pa-pers,2015,29(3),49(in Chinese).肖世维,但年华,马文杰,等.材料导报:研究篇,2015,29(3),49.49 Shin Y C, Lee J H, Jin L H, et al. Journal of Nanobiotechnology,2015,13(1),21.50 Song W, Markel D C, Wang S X, et al. Nanotechnology,2012,23(11),115101.51 Mehrasa M, Anarkoli A O, Rafienia M, et al. International Journal of Polymeric Materials and Polymeric Biomaterials,2016,65(9),457.52 Fischer R L, McCoy M G, Grant S A. Journal of Materials Science: Materials in Medicine,2012,23(7),1645.
渝公网安备50019002502923号 版权所有：《材料导报》编辑部
2019, Vol. 33 
