载中药聚乳酸多孔纳米纤维医用敷料

doi:10.11896/cldb.22080169

材料导报

2024, Vol. 38

Issue (10): 22080169-7 https://doi.org/10.11896/cldb.22080169

高分子与聚合物基复合材料

载中药聚乳酸多孔纳米纤维医用敷料

李亮^1,2,3, 刘淑萍^1,2,3, 裴斐斐⁴, 杨雷锋¹, 刘让同^1,2,3,*

1 中原工学院纺织学院,郑州 451191
2 先进纺织装备技术省部共建协同创新中心,郑州 451191
3 河南省功能纺织材料重点实验室,郑州 451191
4 郑州大学第一附属医院,郑州 450000

Medical Dressing Prepared from Polylactic Acid Porous Nanofiber Loaded Chinese Drugs

LI Liang^1,2,3, LIU Shuping^1,2,3, PEI Feifei⁴, YANG Leifeng¹, LIU Rangtong^1,2,3,*

1 College of Textiles, Zhongyuan University of Technology, Zhengzhou 451191, China
2 Collaborative Innovation Center of Advanced Textile Equipment, Zhengzhou 451191, China
3 Henan Province Key Laboratory of Functional Textile Materials, Zhengzhou 451191, China
4 The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China

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摘要为构筑人体可吸收、抗菌消炎且轻薄柔软的可用于伤口愈合的医用敷料,以聚乳酸为原料,掺杂板蓝根(RI)、柴胡(BC)和茶多酚(GTP)等中药成分,采用氯仿与丙酮二溶剂体系,借助静电纺技术制备聚乳酸(PLA)多孔纳米纤维载中药敷料。通过扫描电镜、红外光谱仪、X射线衍射仪(XRD)和接触角测试仪等手段分析了载中药敷料的微观结构、润湿性能、保水吸液性、抗菌性以及体外降解性能等。结果表明:采用氯仿和丙酮二溶剂体系制备的载中药敷料其纤维具有多孔特征,纤维直径为747～1 550 nm。敷料中所载板蓝根、柴胡、茶多酚与聚乳酸间并未发生负面改性的化学反应。载板蓝根、柴胡、茶多酚的敷料在载药量为3%时对金黄色葡萄球菌抑菌率分别为79.2%、82.5%、75.7%,对大肠杆菌抑菌率分别为79.1%、80.2%、73.9%。同时,较纯聚乳酸敷料,载中药敷料具有较好的透气性和体外降解性,其保水吸液性均提高20%以上,适合用作伤口敷料。

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	李亮
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关键词: 多孔聚乳酸纳米纤维板蓝根茶多酚柴胡敷料抗菌性能

Abstract: In order to construct a medical dressing with the absorbability by human body, antibacterial and anti-inflammatory property, thin and soft characteristic for wound healing, polylactic acid (PLA) porous nanofibers dressings loaded with traditional Chinese medicines of radix isatidis (RI), bupleurum chinense (BC) and green tea polyphenols (GTP) were prepared by electrospinning technique, which used the mixture of chlo-roform and acetone as solvent system. By means of scanning electron microscope, infrared spectrometer, X-ray diffractometer (XRD) and contact angle tester, the microstructure, wettability, water retention and liquid absorption, antibacterial and in vitro degradation of the dressing were analyzed. The results show that the nanofibers of dressing loaded Chinese medicine prepared by chloroform and acetone two solvent system had porous characteristics, and the fiber diameter was about 747—1 550 nm. There was no negative modification reaction between Chinese medicine ingredients and polylactic acid. The antibacterial rates of the dressings loaded with radix isatidis, bupleuri chinense and green tea polyphenols against staphylococcus aureus were 79.2%, 82.5% and 75.7% respectively when the loading drug content was 3%, and the antibacterial rates against Escherichia coli were 79.1%, 80.2% and 73.9% respectively. At the same time, compared with pure polylactic acid dressings, the dres-sings loaded drug have better air permeability and in vitro degradation performance, and their water retention and liquid absorption properties are improved by more than 20%, which is suitable for use as wound dressings.

Key words: porous polylactic acid nanofiber radix isatidis green tea polyphenols bupleurum chinense dressing antibacterial property

出版日期: 2024-05-25 发布日期: 2024-05-28

ZTFLH:

TS174.8

基金资助: 国家重点研发计划(2017YFB0309100)

通讯作者: *刘让同,中原工学院服装学院院长,二级教授,博士,硕士研究生导师,主要研究纺织服装新材料。教育部纺织类专业教学指导委员会委员,河南省教学名师,“纺织之光”教师奖获得者,主持和参与科技部重点专项(包括863计划)、国家自然科学基金、国家技术创新计划、省重点实验室计划等国家和省部级项目32项;主持企业资助项目21项;发表论文168篇;获得中国纺织工业联合会科技进步二等奖2项。ranton@126.com

作者简介: 李亮,硕士研究生导师,中原工学院纺织学院副教授。2008年中原工学院纺织工程专业本科毕业,2011年中原工学院纺织工程专业硕士毕业后到中原工学院工作至今。目前主要从事新型纺织材料、纺织品功能整理等方面的研究工作,发表论文50余篇,其中SCI论文10篇,EI论文15篇。

引用本文:

李亮, 刘淑萍, 裴斐斐, 杨雷锋, 刘让同. 载中药聚乳酸多孔纳米纤维医用敷料[J]. 材料导报, 2024, 38(10): 22080169-7.
LI Liang, LIU Shuping, PEI Feifei, YANG Leifeng, LIU Rangtong. Medical Dressing Prepared from Polylactic Acid Porous Nanofiber Loaded Chinese Drugs. Materials Reports, 2024, 38(10): 22080169-7.

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http://www.mater-rep.com/CN/10.11896/cldb.22080169 或 http://www.mater-rep.com/CN/Y2024/V38/I10/22080169

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