Application Status and Research Progress of Iodine Dressing
NIE Zhen1, CHU Wanli2, NIE Weizhi3, CHEN Yu1,*
1 School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China 2 Department of Burn and Plastic Surgery, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China 3 Shandong Wendeng Osteopathy Hospital,Wendeng 264400,Shandong, China
Abstract: Iodine is a highly effective antibacterial agent with high broad-spectrum antibacterial properties and low drug resistance. It is widely used in dressings to stop bleeding, promote healing, protect wound surface and prevent infection. However, the multiple antibacterial mechanisms of iodine, while guaranteeing antibacterial properties, also lead to high cytotoxicity. Improving the stability of iodine through complexation and achieving slow release of iodine is a common method to reduce its cytotoxicity. With the widely development of wet healing theory, using of new dressings that can provide a micro-moist environment has gradually replaced using of traditional dressings and become the main development direction of iodine-containing dressings. Hence, it has become a research hotspot in recent years to load complexed iodine into new carriers with different functions to prepare low-toxicity and high-efficiency iodine-containing dressings. Currently, the iodine complexing agents are widely used in clinic include povidone, katim, chitosan and its derivatives, but most of them have problems of poor complexing effect and low effective iodine content. It is an important research direction to achieve efficient complexation of iodine by improving the complexing method for iodine-containing dressings at present. The ways to improve the effect of iodine complexes include modifying the traditional iodine complex agent, introducing copolymer to improve the effect of iodine complex, and looking for new complexing agents with excellent properties and unique advantages. For example, iodine recapture can be achieved by copolymerization of povidone with vinyl acetate. Modified lecithin-iodine is usually used for oral administration, the application of which to the dressing can improve the dispersion and uniformity of iodine. On the other hand, most complexed iodine is easily soluble in water, which enables it to be dispersed in a variety of dressings and shows great potential for development. New iodine-containing dressings (such as iodine-containing foam dressings, iodine-containing hydrogel dressings, iodine-containing films, iodine-containing microspheres, and nano-fiber iodine-containing dressings) have a broader application prospect. By integrating the advantages of iodine with carriers of specific functions, the application scenarios of iodine-containing dressings can be diversified and their application fields can be broadened. In this paper,we introduce the types, structures and characteristics of iodine complexes commonly used in dressings in detail, analyze the advantages and limitations of different complexes, review the types, research progress and clinical applications of iodine-containing dressings, and propose the future research focus.
聂真, 褚万立, 聂伟志, 陈煜. 含碘敷料的研究进展与应用现状[J]. 材料导报, 2023, 37(2): 20090021-7.
NIE Zhen, CHU Wanli, NIE Weizhi, CHEN Yu. Application Status and Research Progress of Iodine Dressing. Materials Reports, 2023, 37(2): 20090021-7.
1 National Bureau of Statistics. Health statistics yearbook 2019, China Statistics Press, China, 2019 (in Chinese). 中华人民共和国统计局. 2019年卫生健康统计年鉴, 中国统计出版社, 2019. 2 Guo H W, Gao J, Zhao X Z, et al. Journal of Materials Science and Engineering, 2019, 37(5), 840 (in Chinese). 郭慧文, 高晶, 赵新哲, 等. 材料科学与工程学报, 2019, 37(5), 840. 3 Shahin H, Aldo R B. Acta Biomaterialia, 2020, 107, 25. 4 Swanson T, Keast D. Wounds International, 2017, 8(2), 19. 5 Lin L, Chen J M, Wang H, et al. Materials Reports A:Review Papers, 2019, 33(1), 65 (in Chinese). 林琳, 陈景民, 王会, 等. 材料导报:综述篇, 2019, 33(1), 65. 6 Simoes D, Miguel S P, Ribeiro M P, et al. European Journal of Pharmaceutics and Biopharmaceutics, 2018, 127, 130. 7 Huang H B, Yao J, Zeng G S, et al. Packaging Journal, 2019, 11(4), 10 (in Chinese). 黄海波, 姚进, 曾广胜, 等. 包装学报, 2019, 11(4), 10. 8 Knutson R A, Merbitz L A, Creekmore M A, et al. Southern Medical Journal. 1981, 74(11), 1329. 9 Wu X C. Journal of Nursing Science, 2007(3), 45(in Chinese). 吴湘翠. 护理学杂志, 2007(3), 45. 10 Laudanska H, Gustavson B. The Journal of International Medical Research, 1988, 16(6), 428. 11 Malone M, Schwarzer S, Radzieta M, et al. International Wound Journal, 2019, 16(6), 1477. 12 Sinha R, Agarwal R K, Agarwal M. Burns, 1997, 23(7), 626. 13 Li F, Li J Y. World Latest Medicine Information, 2019, 19(89), 357 (in Chinese). 历凤, 历建英. 世界最新医学信息文摘, 2019, 19(89), 357. 14 Chang S L. Journal of Environment Engineering, 1971, 97, 689. 15 Schreier H, Erdos G, Reimer K, et al. Dermatology (Basel, Switzerland), 1997, 195, 2. 16 Pesce L, Kopp P. International Journal of Pediatric Endocrinology, 2014, 2014(1), 8. 17 Findik R B, Yilmaz G, Celik H T, et al. The Journal of Maternal-Fetal & Neonatal Medicine, 2014, 27(10), 1020. 18 Lividas D P, Piperingos G D, Sfontouris J, et al. The Journal of International Medical Research, 1978, 6(5), 406. 19 Yilmaz D, Tahsin T H, Zorlu P, et al. The Indian Journal of Pediatrics, 2003, 70 (8), 675. 20 Chang S P, Dae H P, Tae S O, et al. International Wound Journal, 2019, 16(2), 379. 21 Arai K, Yamazaki M, Maeda T, et al. International Wound Journal, 2013, 10(5), 542. 22 Patil N, Rao K N, Avinash A, et al. Online Journal of Health and Allied Sciences, 2016, 14(4), 19. 23 Hugo W B. The Journal of Applied Bacteriology, 1991, 71(1), 9. 24 Raymond P, Garman J. Journal of Chemical Education, 1969, 46(5), A356. 25 Bogash R C. American Journal of Health-System Pharmacy, 1955, 12(2), 135. 26 Kang J N. Anthology of Medicine, 1995(5), 436 (in Chinese). 亢江宁. 医学文选, 1995(5), 436. 27 Campbell N, Campbell D. Journal of Wound Care, 2013, 22(8), 401. 28 Ju X J. Journal of Pharmaceutical Practice, 1988(3), 58(in Chinese). 居喜娟. 药学情报通讯, 1988(3), 58. 29 Zhang Z K, Fan H Q. Anhui Chemical Industry, 1992(2), 13 (in Chinese). 张正凯, 范和桥. 安徽化工, 1992(2), 13. 30 Guo R J, Wang X D. Chinese Journal of Disinfection, 2009, 26(4), 368 (in Chinese). 郭睿劼, 王晓东. 中国消毒学杂志, 2009, 26(4), 368. 31 Rodeheaver G, Turnbull V, Edgerton M T, et al. American Journal of Surgery, 1976, 132(1), 67. 32 Prigot A, Roc S. The American Journal of Surgery, 1962, 103(5), 589. 33 Skog E, Arnesjö B, Troëng T, et al. The British Journal of Dermatology, 1983, 109(1), 77. 34 Akiyama H, Oono T, Saito M, et al. Journal of Dermatology. 2004, 31(7), 529. 35 Nahm W J, Mota J A, Rojas S, et al. The American Journal of Case Reports, 2018, 19, 844. 36 Raju R, Kethavath S N, Sangavarapu S M, et al. Wounds: a Compen-dium of Clinical Research and Practice, 2019, 31(3), 85. 37 Williams R L. Wounds: a Compendium of Clinical Research and Practice, 2009, 21(1), 15. 38 Phillips P L, Yang Q P, Davis S, et al. International Wound Journal, 2015, 12(4), 469. 39 Daniel J F, Paul J R, Emma C F, et al. Wound Repair and Regeneration, 2017, 25(1), 13. 40 Hisanori A, Takashi O, Masakazu S, et al. The Journal of Dermatology, 2004, 31(7), 529. 41 Kiamco M M, Atci E, Mohamed A, et al. Applied and Environmental Microbiology, 2017, 83(6), e02783-16. 42 Lin B, Liu X L. Chinese Journal of Optometry & Ophthalmology and Visual Science, 2002(2), 118 (in Chinese). 林冰, 刘晓玲. 眼视光学杂志, 2002(2), 118. 43 Singalavanija A, Ruangvaravate N, Dulayajinda D. Retina (Philadelphia, Pa. ), 2000, 20(4), 378. 44 Shichijo K, Kobayashi S, Kondo T, et al. Chiryō Therapy, 1964, 46, 94. 45 Chen Y, Qiu H Y, Dong M H, et al. Carbohydrate Polymers, 2019, 206, 435. 46 Schenck H U, Simak P, Haedicke E. Chemischer Informationsdienst, 1980, 16, 1. 47 Han J W. Chemical Engineering Joural, 2002, 90(3), 49. 48 Gershenfeld L. American Journal of Surgery, 1957, 94(6), 938. 49 Gilmore O J, Reid C, Strokon A. Postgraduate Medical Journal, 1977, 53(617), 122. 50 Gruber R P, Vistnes L, Pardoe R. Plastic and Reconstructive Surgery, 1975, 55(4), 472. 51 Houang E T, Gilmore O J, Reid C, et al. Journal of Clinical Pathology, 1976, 29(8), 752. 52 Gilmore O J. Annals of the Royal College of Surgeons of England, 1977, 59(2), 93. 53 Borjihan Q, Zhang Z, Zi X Y, et al. Journal of Hazardous Materials, 2020, 384, 121305. 54 Naeema M, Yahya C E, Pradeep K, et al. Journal of Pharmaceutical Sciences, 2014, 103(8), 2211. 55 Chen Y, Dou G F, Luo Y J, et al. Polymer Bulletin, 2005(1), 94 (in Chinese). 陈煜, 窦桂芳, 罗运军, 等. 高分子通报, 2005(1), 94. 56 Chen Z J, Chen Y F, Zheng J, et al. Materials Reports, 2018, 32(S1), 169 (in Chinese). 陈智捷, 陈燕芳, 郑军, 等. 材料导报, 2018, 32(S1), 169. 57 Hears A, Rodriguez N M, Ramos V M, et al. Carbohydrate Polymers, 2001, 44(1), 1. 58 Tang Y, Xie L L, Sai M Z, et al. Materials Science & Engineering C, 2015, 48, 1. 59 Guo R, Sai M Z, Zhang M, et al. Applied Chemistry, 2015, 32(5), 498 (in Chinese). 郭瑞, 赛明泽, 张敏, 等. 应用化学, 2015, 32(5), 498. 60 Alok M, Jagdeep N. Plastic and Reconstructive Surgery, 2003, 111(6), 2105. 61 Liu W. Open Medicine, 2015, 10(1), 452. 62 Cheng L, Gao Y, Zhou J, et al. China Medical Devices, 2011, 26(5), 99 (in Chinese). 程玲, 高勇, 周静, 等. 中国医疗设备, 2011, 26(5), 99. 63 Luo J. Journal of Bioactive and Compatible Polymers, 2010, 25(2), 185. 64 Leveen H H, Jeanette R, Leveen E G, et al. U. S. patent application, USP4381380, 1983. 65 Landsman T L, Touchet T, Hasan S M, et al. Acta Biomaterialia, 2017, 47, 91. 66 Kennedy J F, Methacanon P, Lloyd L L, et al. Carbohydrate Polymers, 1997, 34(4), 315. 67 Lanel B, Barthès-Biesel D, Regnier C, et al. Biorheology, 1997, 34(2), 139. 68 Kannon G A, Garrett A B. Dermatologic Surgery, Official Publication for American Society for Dermatologic Surgery, 1995, 21(7), 175. 69 Wood L, Wood Z, Davis P, et al. Journal of Wound Care, 2010, 19(7), 298. 70 Zhao P L. Structural design and application of long-acting drug release hydrogel. Master's Thesis, Qilu University of Technology, China, 2018 (in Chinese). 赵培丽. 长效药物释放水凝胶结构设计及应用. 硕士学位论文, 齐鲁工业大学, 2018. 71 Pensak J, Juthamart B, Juthamart S, et al. Materials (Basel, Switzerland), 2019, 12(10), 12101628. 72 Du L N, Su C, Shi Y K, et al. Pharmaceutical Journal of Chinese People's Liberation Army, 2010, 26(6), 471 (in Chinese). 杜丽娜, 苏畅, 施沅坤, 等. 解放军药学学报, 2010, 26(6), 471. 73 Summa M, Russo D, Penna I, et al. European Journal of Pharmaceutics and Biopharmaceutics, 2018, 122, 17. 74 Chen Y, Yang Y M, Liao Q P, et al. Materials Science & Engineering C, 2016, 67, 247. 75 Raut P W, Khandwekar A P, Sharma N. Journal of Materials Science, 2018, 53, 1117 . 76 Zhang S L, Kai C C, et al. Applied Surface Science, 2020, 500, 144046. 77 Patil B S, Mastiholimath V S, Kulkarni A R, et al. Oriental Pharmacy and Experimental Medicine, 2011, 11 (2), 123. 78 Nguyen T L U, Farrugia B, Davis T P, et al. Journal of Polymer Science Part A, Polymer Chemistry, 2007, 45, 3256. 79 Wang Q, Jin X Q, Sun J H, et al. International Journal of Polymeric Materials, 2018, 67, 896. 80 Katrin F, Rafael D, Alban D, et al. Journal of Controlled Release, 2017, 262, 127. 81 Athanassiou A, Bayer I S, Liakos I, et al. Italy patent application, TO2012A000258, 2012. 82 Liakos I, Rizzello L, Ilker S B, et al. Carbohydrate Polymers, 2013, 92(1), 176. 83 Osmokrovic A, Jancic I, Vunduk J, et al. Carbohydrate Polymers, 2018, 196, 279. 84 Shadamarshan R P, Balaji H, Rao H S, et al. Colloids and Surfaces B:Biointerfaces, 2018, 171, 698. 85 Wang B L, Ahmad Z S, Huang J, et al. Chemical Engineering Journal, 2018, 343, 379. 86 Semih C, Reza S, Ipek E, et al. Expert Opinion on Drug Discovery, 2017, 12(4), 391. 87 Ulubayram K, Calamak S, Shahbazi R, et al. Current Pharmaceutical Design, 2015, 21(15), 1930. 88 Ignatova M, Markova N, Manolova N, et al. Journal of Biomaterials Science-Polymer Edition, 2008, 19(3), 373. 89 Shitole A A, Raut P, Giram P, et al. Materials Science-Engineering C, 2020, 110, 110731.
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2023, Vol. 37 
