Antibacterial Activity of Quaternized Chitosan Modified ZnO/Attapulgite Nanocomposites
HUI Aiping1, MA Mengting2, YANG Fangfang1, KANG Yuru1, WANG Aiqin1
1 Key Laboratory of Clay Mineral Applied Research of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2 Department of Clinical Laboratory Center, Lanzhou University Second Hospital, Lanzhou 730030, China
Abstract: One-dimensional nanorods of attapulgite (APT) have broad applications prospects in functional carriers. In this work, APT as a carrier to load ZnO nanoparticles, and quaternized chitosan was used to modify the surface charge of ZnO/APT nanocomposites to enhance antibacterial activity. The structure analysis of ZnO/APT nanocomposites were characterized by XRD, FESEM, TEM, EDS and BET, the quaterni-zed chitosan modified ZnO/APT were characterized by FTIR and Zeta potential. The results indicated that ZnO nanoparticles were evenly loaded on the surface of APT, and also the nanocomposites were successfully modified by quaternized chitosan. The minimum inhibitory concentration (MIC) results indicated that 5% quaternized chitosan modified ZnO/APT nanocomposites were 0.25 mg/mL for Staphylococcus aureus and 0.5 mg/mL for Escherichia coli, respectively. Meanwhile, the cytotoxicity test showed that the survival rate of quaternized chitosan modified ZnO/APT to HeLa cells was more than 97.3%, which displayed good biocompatibility.
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2022, Vol. 36 
