Preparations and Biomedical Applications of Conductive Polymers-based Antibacterial Composites:a Review
HUANG Yixuan1,2, YU Peng1,2, ZHOU Zhengnan1,2,*, WANG Zhengao1,2,*, NING Chengyun1,2
1 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China 2 National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
Abstract: The conductive polymers, such as polypyrrole, polythiophene and polyaniline, have excellent conductive properties and biocompatibility, which have been widely applied in biomedical engineering, clinical medicine and other fields. To improve the antibacterial properties of conductive polymers, researchers always combine conductive polymers with antibacterial agents. This strategy helps to reduce the risk of bacterial infection, and keep the excellent properties of conductive polymers from being covered by bacterial biofilm. In this review, we first summarized the antibacterial mechanisms and synthesis strategies of conductive polymers-based antibacterial composites. Then, we introduced their applications in biomedical engineering. Furthermore, we prospected the development of conductive polymers-based antibacterial composites.
1 Le T H, Kim Y, Yoon H. Polymers, 2017, 9, 150. 2 Fincher C, Chen C E, Heeger A J. Physical Review Letters, 1982, 48, 100. 3 Shi G, Zhang Z, Rouabhia M. Biomaterials, 2008, 29, 3792. 4 Balint R, Cassidy N J, Cartmell S H. Acta Biomaterialia, 2014, 10, 2341. 5 Guo B, Ma P X. Biomacromolecules, 2018, 19, 1764. 6 Ning C, Zhou Z, Tan G, et al. Progress in Polymer Science, 2018, 81, 144. 7 da Silva F A G, de Araújo C M S, Alcaraz-Espinoza J J, et al. Journal of Polymer Science Part B:Polymer Physics, 2018, 56, 1063. 8 Smith R E, Totti S, Velliou E, et al. Sensors and Actuators B:Chemical, 2019, 287, 338. 9 Qu J, Zhao X, Ma P X, et al. Acta Biomaterialia, 2018, 72, 55. 10 Harris L G, Richards R G. Injury, 2006, 37, 3. 11 Seshadri D T, Bhat N V. Sen'i Gakkaishi, 2005, 61, 103. 12 Au K M, Lu Z, Matcher S J, et al. Advanced Materials, 2011, 23, 5792. 13 Zhou W, Lu L, Chen D, et al. Journal of Materials Chemistry B, 2018, 6, 3128. 14 Dhivya C, Vandarkuzhali S A A, Radha N. Arabian Journal of Chemistry, 2019, 12, 3785. 15 Boomi P, Prabu H G. Colloids and Surfaces A, 2013, 429, 51. 16 Mei L, Zhang X, Wang Y, et al. Polymer Chemistry, 2014, 5, 3038. 17 Ge L, Li Q, Wang M, et al. International Journal of Nanomedicine, 2014, 9, 2399. 18 Simchi A, Tamjid E, Pishbin F, et al. Nanomedicine, 2011, 7, 22. 19 Rai M, Yadav A, Gade A. Biotechnology Advances, 2009, 27, 76. 20 Cady N C, Behnke J L, Strickland A D. Advanced Functional Materials, 2011, 21, 2506. 21 Zhang X, Yang C, Yang K. ACS Applied Materials & Interfaces, 2020, 12, 361. 22 Makvandi P, Gu J T, Zare E N, et al. Acta Biomaterialia, 2020, 101, 69. 23 Ateh D D, Navsaria H A, Vadgama P. Journal of the Royal Society Interface, 2006, 3, 741. 24 Sirivisoot S, Pareta R A, Webster T J. Journal of Biomedical Materials Research A, 2011, 99, 586. 25 Sirivisoot S, Pareta R, Webster T J. Nanotechnology, 2011, 22, 085101. 26 Ungureanu C, Popescu S, Purcel G, et al. Materials Science & Engineering C-Materials for Biological Applications, 2014, 42, 726. 27 Dutta P K, Tripathi S, Mehrotra G K, et al. Food Chemistry, 2009, 114, 1173. 28 Wu T, Pan Y, Bao H, et al. Materials Chemistry and Physics, 2011, 129, 932. 29 Zhang J, Neoh K G, Hu X, et al. Biomaterials, 2014, 35, 7690. 30 Khan S, Narula A K. European Polymer Journal, 2016, 81, 161. 31 Kuralay F, Demirci S, Kiristi M, et al. Colloids and Surfaces B:Biointerfaces, 2014, 123, 825. 32 Talebi A, Labbaf S, Karimzadeh F. Polymer Testing, 2019, 75, 254. 33 Zhao X, Li P, Guo B, et al. Acta Biomaterialia, 2015, 26, 236. 34 Yu J, Horsley J R, Abell A D. Accounts of Chemical Research, 2018, 51, 2237. 35 Xing J, Qi S, Wang Z, et al. Advanced Functional Materials, 2019, 29, 1806353. 36 Jotiram K P, Prasad R G S V, Jakka V S. Nano Biomedicine and Engineering, 2012, 4, 144. 37 Qu J, Zhao X, Liang Y, et al. Chemical Engineering Journal, 2019, 362, 548. 38 Han J, Wang M, Hu Y, et al. Progress in Polymer Science, 2017, 70, 52. 39 Guo C X, Zheng X T, Ng S R, et al. Chemical Communications, 2011, 47, 2652. 40 Parthiban E, Kalaivasan N, Sudarsan S. Arabian Journal of Chemistry, 2020, 13, 4751. 41 Bogdanovic U, Vodnik V, Mitric M, et al. ACS Applied Materials & Interfaces, 2015, 7, 1955. 42 Ting Y P, Neoh K G, Kang E T, et al. Journal of Chemical Technology and Biotechnology, 1994, 59, 31. 43 Ismayil K M M, Varghese A, Antony R. Journal of Elastomers & Plastics, 2019, 52, 103. 44 Zengin H, Aksin G, Zengin G, et al. Polymer Engineering & Science, 2019, 59, E182. 45 Ahmad N, Sultana S, Kumar G, et al. Journal of Environmental Chemical Engineering, 2019, 7, 102804. 46 Mirmohseni A, Rastgar M, Olad A. Journal of Applied Polymer Science, 2020, 137, 48825. 47 Carlson C, Hussain S M, Schrand A M, et al. Journal of Physical Che-mistry B, 2008, 112, 13608. 48 Xu J, Hu J, Quan B, et al. Macromolecular Rapid Communications, 2009, 30, 936. 49 Liu K, Nasrallah J, Chen L, et al. Carbohydrate Polymers, 2018, 194, 97. 50 Chaloupka K, Malam Y, Seifalian A M. Trends in Biotechnology, 2010, 28, 580. 51 Reidy B, Haase A, Luch A, et al. Materials, 2013, 6, 2295. 52 Ercan B, Webster T J. International Journal of Nanomedicine, 2008, 3, 477. 53 Ercan B, Webster T J. Biomaterials, 2010, 31, 3684. 54 Meng S, Zhang Z, Rouabhia M. Journal of Bone and Mineral Metabolism, 2011, 29, 535. 55 Ignatova M, Labaye D, Lenoir S, et al. Langmuir, 2003, 19, 8971. 56 Zhu B, Li Y, Huang F, et al. Biomaterials Science, 2019, 7, 4730. 57 Guo Y, Jia S, Qiao L, et al. Colloids and Surfaces B:Biointerfaces, 2020, 194, 111186. 58 Rikhari B, Pugal Mani S, Rajendran N. Carbohydrate Polymers, 2018, 189, 126. 59 Yu Y, Tao B, Sun J, et al. Materials Letters, 2020, 268, 127420. 60 Ong J L, Chan D C. Critical Reviews in Biomedical Engineering, 2000, 28, 667. 61 Madhan K A, Adesina A Y, Hussein M A, et al. Materials Science & Engineering C-Materials for Biological Applications, 2019, 98, 482. 62 Subramani R, Elangomannan S, Louis K, et al. ACS Applied Materials & Interfaces, 2016, 8, 12404. 63 Haraguchi Y, Shimizu T, Yamato M, et al. Biomaterials, 2006, 27, 4765. 64 Jasenska D, Kasparkova V, Radaszkiewicz K A, et al. Carbohydrate Polymers, 2021, 253, 117244. 65 Chakraborty P, Oved H, Bychenko D, et al. Advanced Materials, 2021, 33, e2008715. 66 Dong R, Zhao X, Guo B, et al. ACS Applied Materials & Interfaces, 2016, 8, 17138. 67 Talikowska M, Fu X, Lisak G. Biosensors and Bioelectronics, 2019, 135, 50. 68 Mohana S P, Rangharajan K K, Akbari E, et al. Lab on a Chip, 2021, 21, 319. 69 Zhao X, Wu H, Guo B, et al. Biomaterials, 2017, 122, 34. 70 Zhao Y, Li Z, Song S, et al. Advanced Functional Materials, 2019, 29, 1901474. 71 Feng L, Shi W, Chen Q, et al. Advanced Healthcare Materials, 2021, 10, e2100784. 72 Zhang Q, Qiao Y, Zhu J, et al. Composites Part B:Engineering, 2021, 223, 109140. 73 Zhang N, Yue L, Xie Y, et al. IEEE Journal of Translational Enginee-ring in Health and Medicine, 2018, 6, 2700310. 74 Zhang K, Kang N, Zhang B, et al. Advanced Electronic Materials, 2020, 6, 2000259. 75 Boomi P, Poorani G P, Palanisamy S, et al. Journal of Cluster Science, 2019, 30, 715. 76 Ahmad N, Sultana S, Faisal S M, et al. RSC Advances, 2019, 9, 41135. 77 Hosseini H, Zirakjou A, Goodarzi V, et al. International Journal of Biological Macromolecules, 2020, 152, 57. 78 He J, Liang Y, Shi M, et al. Chemical Engineering Journal, 2020, 385, 123464.