聚羟基脂肪酸酯(PHAs)基止血材料研究进展

doi:10.11896/cldb.21010218

材料导报

2023, Vol. 37

Issue (3): 21010218-9 https://doi.org/10.11896/cldb.21010218

高分子与聚合物基复合材料

聚羟基脂肪酸酯(PHAs)基止血材料研究进展

吴远东^1,2, 郑维爽^1,2, 李源遽^1,2, 都贝宁^1,2, 张兴儒^1,2, 李家龙^1,2, 于盛洋^1,2, 肖忆楠^1,2, 赖琛^1,2, 盛立远^1,2, 黄艺^1,2,3,*

1 北京大学深圳研究院,广东深圳 518057
2 深港产学研基地,广东深圳 518057
3 北京大学环境科学与工程学院,北京 100871

Research Progress on Polyhydroxyalkanoates (PHAs)-based Hemostatic Materials

WU Yuandong^1,2, ZHENG Weishuang^1,2, LI Yuanju^1,2, DU Beining^1,2, ZHANG Xingru^1,2, LI Jialong^1,2, YU Shengyang^1,2, XIAO Yinan^1,2, LAI Chen^1,2, SHENG Liyuan^1,2, HUANG Yi^1,2,3,*

1 Shenzhen Institute,Peking University, Shenzhen 518057, Guangdong, China
2 PKU-HKUST ShenZhen-HongKong Institution, Shenzhen 518057, Guangdong, China
3 School of Environmental Science and Engineering, Peking University, Beijing 100871, China

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摘要在意外事故、自然灾害及军事冲突中,人体会受到严重外部创伤,出现大量的不可控出血,极易导致伤员的缺血性休克甚至死亡。因此,伤口的快速止血是提高伤者存活率的关键,快速止血一般需要借助止血材料实现。聚羟基脂肪酸酯(PHAs)是一种天然高分子化合物,具有良好的生物相容性、生物可降解性、可改性等特性,其降解产物还具有促进活体细胞增殖和分化的作用,可加速伤口愈合,是一种极具潜力的止血材料,受到生物医学研发人员的广泛关注。但在应用过程中,PHAs基材料在韧性、抗菌和凝血能力方面仍然存在缺陷。因此,若想开发基于PHAs的止血材料,必须对其韧性、抗菌能力及凝血性能进行改善。本文综述了近年来PHAs基材料在韧性、抗菌能力以及凝血性能等方面的研究进展,可为PHAs基止血材料的研究开发提供参考。PHAs基止血材料具有较高的经济价值,相关研究对严重创伤的救护和新型生物材料的应用推广具有重要意义。

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	吴远东
	郑维爽
	李源遽
	都贝宁
	张兴儒
	李家龙
	于盛洋
	肖忆楠
	赖琛
	盛立远
	黄艺

关键词: 聚羟基脂肪酸酯力学性能止血材料凝血抗菌

Abstract: During accidents, natural disasters and war, the body of human may suffer serious physical trauma, which will lead uncontrollable massive blood loss. This may further result in ischemic shock and death in the injured. Therefore, fast hemostasis of wound is the key to improve the survival rate of the injured. Fast hemostasis is generally based on using hemostatic materials. Polyhydroxyalkanoates (PHAs), a natural polymer compound, has good biocompatibility, biodegradability and modifying properties. The degradation products of PHAs can also promote the proliferation and differentiation of cells, which can further facilitate healing of wound. Hence PHAs is a good matter of developing hemostatic materials and has attracted extensive attention from biomedical materials researchers. However, PHAs-based materials still have some shortcomings, such as poor toughness, low antibacterial and coagulation performance. Before developing PHAs-based hemostatic materials, the toughness, antibacterial capacity and coagulation performance need to be improved. This review summarizes the research progress of PHAs-based hemostatic materials in recent years, which may provide effective methods and instructions for researching and developing the PHAs-based hemostatic materials. The successful development of PHAs-based hemostatic materials with great socioeconomic value will have significance for emergency of military and sustainable development of mankind.

Key words: polyhydroxyalkanoates mechanical property hemostatic material coagulation antibacterial

出版日期: 2023-02-10 发布日期: 2023-02-23

ZTFLH:

R318.08

基金资助: 深圳市中央引导地方科技发展专项资金(2021Szvup001);广东省海洋经济发展(海洋六大产业)专项资金项目(粤自然资合[2020]034号);深圳市基础研究学科布局项目(JCYJ20170815153143221; JCYJ202000109144604020);中国博士后科学基金(2021M690247);深港产学研创新基金(HT-JD-CXY-201902; HT-JD-CXY-201907)

通讯作者: ^*yhuang@pku.edu.cn，黄艺,1997年7月毕业于德国比勒菲尔德大学,获自然科学博士学位。现为北京大学环境科学与工程学院教授。自1998年始,在北京大学城市与环境学院和环境科学与工程学院从事环境生态和环境生物技术相关的科研及教学工作。在污染环境和极端生境下的微生物生态过程、流域水生态系统过程和环境修复生物技术的研究方面具有独特的建树。先后主持了国家重大水专项、环保部公益项目、国家自然科学基金以及科技部重点研发计划等国家项目,以及ITTO、UNEP等国际重要合作科研项目20多项。在国内外具有重要影响力的杂志发表相关科研论文100余篇,获得专利4项。

作者简介: 吴远东,2012年本科毕业于南华大学资源环境与安全工程学院,2017年7月在中国科学院西北生态环境资源研究院取得地球化学专业博士学生,2018—2020年在西安交通大学从事博士后研究工作,现为北京大学深圳研究院生物医学工程中心副研究员。主要从事生物可降解医用材料、抗菌包装材料及水环境修复纳米复合材料研发。目前,发表SCI论文30余篇,总被引300余次。

引用本文:

吴远东, 郑维爽, 李源遽, 都贝宁, 张兴儒, 李家龙, 于盛洋, 肖忆楠, 赖琛, 盛立远, 黄艺. 聚羟基脂肪酸酯(PHAs)基止血材料研究进展[J]. 材料导报, 2023, 37(3): 21010218-9.
WU Yuandong, ZHENG Weishuang, LI Yuanju, DU Beining, ZHANG Xingru, LI Jialong, YU Shengyang, XIAO Yinan, LAI Chen, SHENG Liyuan, HUANG Yi. Research Progress on Polyhydroxyalkanoates (PHAs)-based Hemostatic Materials. Materials Reports, 2023, 37(3): 21010218-9.

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http://www.mater-rep.com/CN/10.11896/cldb.21010218 或 http://www.mater-rep.com/CN/Y2023/V37/I3/21010218

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