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材料导报  2023, Vol. 37 Issue (5): 21030008-9    https://doi.org/10.11896/cldb.21030008
  高分子与聚合物基复合材料 |
胶原基复合止血材料的研究进展及展望
闫星雨1,2, 但年华1,2, 陈一宁1,2, 但卫华1,2,*, 李正军1,2
1 四川大学皮革化学与工程教育部重点实验室,成都 610065
2 四川大学生物医学工程技术研究中心,成都 610065
Research Progress and Development Direction of Collagen-based Composite Hemostatic Materials
YAN Xingyu1,2, DAN Nianhua1,2, CHEN Yining1,2,*, DAN Weihua1,2,*, LI Zhengjun1,2
1 Key Laboratory of Leather Chemistry and Engineering, Sichuan University, Chengdu 610065, China
2 Research Center of Biomedical Engineering, Sichuan University, Chengdu 610065, China
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摘要 胶原蛋白可用于多种止血场景,并凭借优越的性能和易于获取的特点逐渐取代传统止血材料。然而,不同剂型的胶原止血剂都存在各自的缺陷,如力学性能差、粘附性差等。虽然提纯或交联改性胶原能在一定程度上获得改善,但作用有限,临床应用仍深受限制。天然生物及其衍生物材料是来源丰富的止血剂,具有生物相容性和良好的吸收和降解性能。广泛使用的材料包括壳聚糖、纤维蛋白胶、藻酸盐和氧化纤维素,以及近年来逐渐受到重视的传统中药材。因此,胶原蛋白与天然生物及其衍生物材料交联而成的胶原蛋白基复合止血材料,有望成为极具前景的生物医用止血材料。本文综述了不同类型胶原基复合止血材料的研究进展,总结了各自的优缺点,最后对胶原基复合止血材料的未来发展方向进行了探讨。
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闫星雨
但年华
陈一宁
但卫华
李正军
关键词:  胶原  止血  壳聚糖  氧化纤维素  纤维蛋白胶  海藻酸盐  传统中药材    
Abstract: Collagen can be used in various hemostatic scenarios and has gradually replaced traditional hemostatic materials due to its superior perfor-mance and easy procurement from animals. However, regardless of form, collagen hemostatic agents have disadvantages such as poor mechanical properties and weak adhesion. Although purifying or modifying the cross-linking agent of such hemostatic agents can improve their performance to some extent, their fundamental structure has not been effectively changed, limiting clinical application. Natural biomaterials or their derivatives are rich sources of biocompatible hemostatic agents with sound absorption and degradation properties. Collagen-based composite hemostatic materials formed by cross-linking collagen with natural biomaterials or derivatives show significantly improved performances and have become valuable biomedical materials. The widely used materials for this purpose include chitosan, fibrin glue, alginate, and oxidized cellulose. Additionally, the application of traditional Chinese medicinal materials has gradually gained attention in recent years. This article reviews the research progress on different types of collagen-based hemostatic materials and summarizes their respective advantages and disadvantages. Finally, the future direction of developing of collagen-based composite hemostatic materials is discussed.
Key words:  collagen    hemostasis    chitosan    oxidized cellulose    fibrin glue    alginate    traditional Chinese medicinal materials
出版日期:  2023-03-10      发布日期:  2023-03-14
ZTFLH:  O636.9  
基金资助: 皮革化学与工程教育部重点实验室(四川大学)开放课题基金(SCU2021D005);中央高校基本科研业务费专项资金(专职博士后、基地引导专项)(20826041E4156);国家自然科学基金(514730001)
通讯作者:  *但卫华,博士,教授,博士研究生导师,享受国务院政府特殊津贴专家,四川省学术技术带头人。1982年于成都科技大学取得学士学位,1992年于成都科技大学取得硕士学位,1999年于四川联合大学取得工学博士学位,现任四川大学轻工科学与工程学院教授,四川大学生物医学工程技术研究中心医用生物质材料研究室负责人。先后在国内外专业刊物上发表论文500余篇,获国家专利授权60余项,出版学术专著及教材8部。主要研究方向:生物质化学与工程、生物医学材料、绿色皮革化工材料以及功能复合材料等。danweihua@scu.edu.cn   
作者简介:  闫星雨,2019年6月毕业于西北农林科技大学,获得工学学士学位。现为四川大学轻工科学与工程学院硕士研究生,师从但卫华教授,主要研究领域为胶原基生物医用材料。
引用本文:    
闫星雨, 但年华, 陈一宁, 但卫华, 李正军. 胶原基复合止血材料的研究进展及展望[J]. 材料导报, 2023, 37(5): 21030008-9.
YAN Xingyu, DAN Nianhua, CHEN Yining, DAN Weihua, LI Zhengjun. Research Progress and Development Direction of Collagen-based Composite Hemostatic Materials. Materials Reports, 2023, 37(5): 21030008-9.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.21030008  或          http://www.mater-rep.com/CN/Y2023/V37/I5/21030008
1 Kauvar D S, Lefering R, Wade C E. Journal of Trauma & Acute Care Surgery, 2006, 60(6), S3.
2 Hamada S R, Rosa A, Gauss T, et al. Critical Care, 2018, 22(1), 113.
3 Chen G B, Yang H, Zhou J Y, et al. Journal of Chongqing University of Technology(Natural Science), 2022, 36(2), 214.
陈国宝, 杨欢, 周江一, 等. 重庆理工大学学报(自然科学), 2022, 36(2), 214.
4 Wang Q, Li L, Wang H R, et al. Journal of Functional Materials, 2021, 52(1), 1214.
王倩, 李莉, 王焕然, 等. 功能材料, 2021, 52(1), 1214.
5 Luo Y R, Lu C L, Yang D X, et al. Journal of Functional Materials, 2022, 53(8), 8054.
罗艳荣, 卢春兰, 杨东旭, 等. 功能材料, 2022, 53(8), 8054.
6 Zou Y, Liu W J. The Science and Technology of Gelatin, 2010, 30(1), 6 (in Chinese).
邹勇, 刘文杰. 明胶科学与技术, 2010, 30(1), 6.
7 Zhang Z, Cong Y L, Tu Z G. Chinese Journal of Laboratory Medicine, 2006, 29(5), 428 (in Chinese).
张卓, 丛玉隆, 涂植光. 中华检验医学杂志, 2006, 29(5), 428.
8 Sun L, Li B, Jiang D, et al. Colloids & Surfaces B Biointerfaces, 2017, 159, 89.
9 Cheng X, Shao Z, Li C, et al. Plos One, 2017, 12(1), e0169731.
10 Jiang X, Wang Y, Fan D, et al. Journal of Biomaterials Applications, 2017, 31(8), 1099.
11 Duan Z G. The study on the properties of human-like collagen hematisc-hesis sponge, Master's Thesis, Northwest University, China, 2008 (in Chinese).
段志广. 类人胶原蛋白止血海绵的性能研究. 硕士学位论文, 西北大学, 2008.
12 Muthukumar T, Prabu P, Ghosh K, et al. Colloids & Surfaces B Bioin-terfaces, 2014, 113, 207.
13 Wang X. Journal of Bioactive and Compatible Polymers, 2006, 21(1), 39.
14 Lyu X Y, Ou M M, Huang X F. Journal of Clinical and Experimental Medicine, 2019, 18(17), 1796 (in Chinese).
吕晓玉, 欧明明, 黄晓峰. 临床和实验医学杂志, 2019, 18(17), 1796.
15 Kikuchi M, Matsumoto H N, Yamada T, et al. Biomaterials, 2004, 25(1), 63.
16 Cheung D T, Nimni M E. Connective Tissue Research, 1982, 10(2), 187.
17 Sung H W, Hsu H L, Shih C C, et al. Biomaterials, 1996, 17(14), 1405.
18 Drexler J W, Powell H M. Tissue Engineering: Part C, 2011, 17(1), 9.
19 Hu Y, Liu L, Dan W, et al. International Journal of Biological Macromolecules, 2013, 55, 221.
20 Bai Z X, Dan N H, Dan W H, et al. Materials Reports B:Resperch Papers, 2018, 32(10), 3628 (in Chinese).
白忠祥, 但年华, 但卫华, 等. 材料导报:研究篇, 2018, 32(10), 3628.
21 Pei Y, Zheng X J, Tang K Y. Chinese Polymer Bulletin, 2010(2), 58 (in Chinese).
裴莹, 郑学晶, 汤克勇. 高分子通报, 2010(2), 58.
22 Liu X H. West Leather, 2012, 34(8), 13 (in Chinese).
刘新华. 西部皮革, 2012, 34(8), 13.
23 Rao S B, Sharma C P. Journal of Biomedical Materials Research, 1997, 34(1), 21.
24 Benesch J, Tengvall P. Biomaterials, 2002, 23(12), 2561.
25 Hu Z, Zhang D Y, Lu S T, et al. Marine Drugs, 2018, 16(8),273.
26 Yan T S, Cheng F, Wei X J, et al. Carbohydrate Polymers, 2017, 170, 271.
27 Zheng C, Liu X, Luo X, et al. Journal of Materials Chemistry B, 2019, 7(46), 7338.
28 Ma M. Study of biocompatibility and hemostatic effect of chitosan-human-like collagen sponge, Master's Thesis, Northwest University, China, 2008 (in Chinese).
马茂. 壳聚糖-类人胶原蛋白海绵的生物相容性及止血效果研究. 硕士学位论文, 西北大学, 2008.
29 Wang Y, Huang Y, Lin C P, et al. Fujian Journal of Agricultural Sciences, 2013, 28(4), 315 (in Chinese).
王茵, 黄煜, 林彩平, 等. 福建农业学报, 2013, 28(4), 315.
30 Chen M M, Huang Y Q, Hao G, et al. Journal of Applied Polymer Science, 2015, 131(21), 8558.
31 Shi X, Fang Q, Ding M, et al. Journal of Biomaterials Applications, 2016, 30(7), 1092.
32 Ding C C, Tian M D, Feng R, et al. ACS Biomaterials Science & Engineering, 2020, 6(7), 3855.
33 Zhao S H, Hu Q L, Zhong Z Y, et al. Chinese Journal of Comparative Medicine, 2010(5), 61 (in Chinese).
赵士海, 胡庆柳, 钟志勇, 等. 中国比较医学杂志, 2010(5), 61.
34 Zhao H Q, Wang D T. Chinese Journal of Veterinary Medicine, 2003, 2003(1), 17 (in Chinese).
赵海全, 王冬桃. 中国兽医杂志, 2003, 2003(1), 17.
35 Zhang S D. Guide of China Medicine, 2013, 11(16), 98 (in Chinese).
张松达. 中国医药指南, 2013, 11(16), 98.
36 Meng Z Y, Dou G F, Liu M X, et al. Military Medical Sciences, 2002, 26(1), 51 (in Chinese).
孟志云, 窦桂芳, 刘敏霞, 等. 军事医学科学院院刊, 2002, 26(1), 51.
37 Spotnitz W D. ISRN Surgery, 2014, 2014, 203943.
38 Stalker T J, Welsh J D, Tomaiuolo M, et al. Blood, 2014, 124(11), 1824.
39 Janmey P A, Winer J P, Weisel J W. Journal of the Royal Society Interface, 2009, 6(30), 1.
40 Li W D, Deng L J, Fan H H, et al. In: Conference Proceedings of the 22nd Guangdong Pharmacist Week Conference in 2016. Guangdong, 2016, pp.1292 (in Chinese).
李伟达, 邓乐君, 樊鸿浩, 等. 2016年广东省药师周大会论文集, 2016, pp.1292.
41 Wang Y, Lu W. Journal of Biomedical Engineering, 2009, 2009(4), 922 (in Chinese).
王勇, 陆伟. 生物医学工程学杂志, 2009, 2009(4), 922.
42 Dickneite G, Metzner H J, Kroez M, et al. Journal of Surgical Research, 2002, 107(2), 186.
43 Zhang D X, He Z X. Chinese Journal of Critical Care Medicine, 2005, 25(5), 353 (in Chinese).
张德兴, 何忠杰. 中国急救医学, 2005, 25(5), 353.
44 Pallaske F, Seebauer C, Kaltofen D, et al. Journal of Visceral Surgery, 2021, 158(1), 11.
45 Zhao X, Cao X H, Ma Y Y, et al. Chinese Journal of Blood Transfusion, 2010, 23(4), 250 (in Chinese).
赵雄, 曹晓涵, 马玉媛, 等. 中国输血杂志, 2010, 23(4), 250.
46 Wang Q Z, Wang C H, Zhang W B, et al. China Medical Herald, 2010, 2010(17), 53 (in Chinese).
王秋卓, 王彩虹, 张文博, 等. 中国医药导报, 2010, 2010(17), 53.
47 Li W D, Deng L J, Li J, et al. Shandong Medical Journal, 2017, 2017(9), 31 (in Chinese).
李伟达, 邓乐君, 李健, 等. 山东医药, 2017, 2017(9), 31.
48 Croisier F, Jérme C. European Polymer Journal, 2013, 49(4), 780.
49 Segal H C, Hunt B J, Gilding K. Journal of Biomaterials Applications, 1998, 12(3), 249.
50 Huang H, Chen H, Wang X, et al. ACS Biomaterials Ence & Engineering, 2019, 5(10), 549
51 Bo R L, Jin W H, Choi Y Y, et al. Biomaterials, 2012, 33(3), 837.
52 Jun Y, Kang A R, Lee J S, et al. Biomaterials, 2013, 34(15), 3784.
53 Wu J, Wang G H, Zhang H, et al. Key Engineering Materials, 2011, 474-476, 1935.
54 Jin J, Ji Z, Xu M, et al. ACS Biomaterials Science & Engineering, 2018, 4(7), 2541.
55 Liu C, Shi Z, Sun H, et al. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2020, 109(8), 1116.
56 Zong J. The study on the anti-immersed collagen combined medical dressing, Master's Thesis, Shanghai Ocean University, China, 2016 (in Chinese).
宗杰. 防海水浸泡胶原蛋白复合医用敷料研究. 硕士学位论文, 上海海洋大学, 2016.
57 Song Y Z, Ren Y, Lou R Y, et al. Journal of Functional Materials, 2016, 47(11), 136 (in Chinese).
宋益哲, 任英, 娄茹云, 等. 功能材料, 2016, 47(11), 136.
58 Guo W Y, Guo L L, Liu Z Y, et al. New Chemical Materials, 2019, 47(11), 162 (in Chinese).
刘文迎, 郭亮亮, 刘泽员, 等. 化工新型材料, 2019, 47(11), 162.
59 Zhang X, Zhou H, Yang Y H, et al. Chemical Journal of Chinese Universities, 2015, 36(10), 2040 (in Chinese).
张霞, 周浩, 杨宇红, 等. 高等学校化学学报, 2015, 36(10), 2040.
60 Palm M D, Altman J S, et al. Dermatol Surg, 2008, 34(4), 431.
61 Nicola T, Di L A, Vincenzo L, et al. Surgery Research and Practice, 2016, 2016, 3058754.
62 Slezak P, Monforte X, Ferguson J, et al. Journal of Materials Science Materials in Medicine, 2018, 29(6), 71.
63 Kakaei F, Seyyed Sadeghi M S, Sanei B, et al. HPB Surgery, 2013, 2013, 587608.
64 Cheng W, Li H, Zheng X, et al. Physical Chemistry Chemical Physics Pccp, 2016, 18(42), 29183.
65 Ponni R, Vuorinen T, Kontturi E. Bioresources, 2012, 7(4), 6077.
66 Kamel S, Ali N, Jahangir K, et al. Express Polymer Letters, 2008, 2(11), 758.
67 Baker A A, Helbert W, Sugiyama J, et al. Applied Physics A-Materials Science & Processing, 1998, 66, S559.
68 Knight P E, Podczeck F, Newton J M. Journal of Pharmaceutical Sciences, 2009, 98(6), 2160.
69 Eichhorn S J, Young R J. Cellulose, 2001, 8(3), 197.
70 Wu Q, Henriksson M, Liu X, et al. Biomacromolecules, 2007, 8(12), 3687.
71 Cheng W, He J, Chen M, et al. Fibers and Polymers, 2016, 17(8), 1277.
72 Li H, Cheng W, Liu K, et al. Carbohydrate Polymers, 2017, 165, 30.
73 Han Z B, Xie J X. Guangxi Journal of Traditional Chinese Medicine, 2009, 32(2), 6 (in Chinese).
韩邦志, 谢金鲜. 广西中医药, 2009, 32(2), 6.
74 Gallardo R, Aguilar M, Silva P, et al. Carbohydrate Polymers, 2018, 192, 84.
75 Luisa G C, Claudia C, Martha L. Marine Drugs, 2017, 15(10), 328.
76 Li F, Luo P, Liu H. Marine Drugs, 2018, 16(4), 106.
77 Lu B, Hu S S, Zhu X, et al. Health Research, 2011, 31(2), 94 (in Chinese).
卢斌, 胡思思, 诸娴, 等. 健康研究, 2011, 31(2), 94.
78 Ma C X. The study of the Yunnan Baiyao and Panax Notoginseng Saponins spring on the anastomosis. Master's Thesis, University of South China, China, 2012 (in Chinese).
马传勋. 云南白药及其活性成分三七总皂苷对肠吻合口的作用研究. 硕士学位论文, 南华大学, 2012.
79 Liu X H. Preparation and evaluation of two novel functional hemostatic biomaterials based on the most advanced collagen aggregate. Ph. D. Thesis, Sichuan University, China, 2017 (in Chinese).
刘新华. 基于高层级胶原聚集体的功能性止血材料的制备与性能. 博士学位论文, 四川大学, 2017.
80 Liu W. Collagen extracted from fetal bovine and application on hemostatic material, Master's Thesis, Sichuan University, China, 2018 (in Chinese).
刘伟. 胎牛皮源胶原的提取及在止血材料中的应用. 硕士学位论文, 四川大学, 2018.
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[2] Haoqi HU,Cheng XU,Lijing YANG,Henghua ZHANG,Zhenlun SONG. Recent Advances in the Research of High-strength and High-conductivity CuCrZr Alloy[J]. Materials Reports, 2018, 32(3): 453 -460 .
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