介孔硅止血材料的研究现状及应用前景

doi:10.11896/cldb.21010168

材料导报

2022, Vol. 36

Issue (23): 21010168-9 https://doi.org/10.11896/cldb.21010168

无机非金属及其复合材料

介孔硅止血材料的研究现状及应用前景

张卓然^1,2, 李钒^1,*, 侯敏², 张媛媛², 丁晟¹, 魏晓慧¹, 林松¹

1 军事科学院卫勤保障技术研究所,天津 300161
2 陆军第951医院超声诊断科,新疆库尔勒 841000

Development of Mesoporous Silica Hemostatic Materials and Their Application Prospects

ZHANG Zhuoran^1,2, LI Fan^1,*, HOU Min², ZHANG Yuanyuan², DING Sheng¹, WEI Xiaohui¹, LIN Song¹

1 Institute of Medical Support Technology, Academy of Military Science, Tianjin 300161, China
2 Department of Ultrasound Diagnosis, Army Hospital 951, Korla 841000, Xinjiang, China

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摘要失控的出血是战时与和平时期创伤性死亡的重要原因,止血材料研究是院前急救领域的热点问题。院前止血材料在止血速率、环境适应性和生物安全性方面均有较高的要求。现有的高分子类和无机类止血材料,往往存在性能不稳定、环境适应性差、成本高或潜在安全风险等问题。微观结构与沸石等相似的介孔二氧化硅(介孔硅)是最有潜力的无机类止血材料之一,良好的生物相容性和环境适应性、多孔结构和高比表面积、可调节的孔径和组分及表面易修饰等特性使其极其适用于院前急救止血。
介孔硅材料主要通过自组装的方式构建,水热/溶剂热合成法是最典型的合成工艺,也有研究运用微波辐射合成法或超声合成法,可缩短介孔硅制备时间,降低成本。在介孔硅成形过程中,需要将前驱体结构中的致孔模板剂除去,保留无机骨架结构,从而形成有序的多孔结构。模板剂的脱除是介孔硅合成的关键环节,常用的方法有高温煅烧、溶剂萃取、超临界萃取、微波加热等。研究显示,介孔硅材料孔径越大凝血效果越好,促进细胞分化效果越明显。因此,引入扩孔工艺有望提升介孔硅材料的止血性能。此外,介孔硅可与金属离子、功能药物、有机高分子等复合,在快速止血的同时实现抗菌、促愈合等多种功能。介孔硅的形貌、成分、表面修饰等对其生物安全性均有一定影响,可通过材料设计、功能负载等来优化材料的生物安全性,增强其在院前急救中的可操作性和实用性。
本文综述了介孔硅的快速合成方法,介绍了介孔硅材料制备过程中模板剂脱除、孔径控制、功能拓展的方法,讨论了介孔硅作为止血材料的生物安全性问题,并对介孔硅材料的制备及未来止血应用前景进行了展望。

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关键词: 介孔硅止血材料合成生物安全性

Abstract: Uncontrolled bleeding is an important cause of traumatic death in wartime and peacetime. The research on hemostatic materials is a hot issue in the field of pre-hospital first aid. The pre-hospital hemostatic materials have high requirements in terms of hemostatic rate, environmental adaptability and biological safety. The existing polymer and inorganic hemostatic materials often have the problems of unstable performance, poor environmental adaptability, high cost and potential safety risks. Mesoporous silica with a similar microstructure to zeolite is one of the most potential inorganic hemostatic materials, which is extremely suitable for pre-hospital emergency hemostasis, according to its good biocompatibility and environmental adaptability, porous structure and high specific surface area, adjustable pore size and composition, and facile surface modification.
Mesoporous silica materials are mainly constructed by molecular self-assembly, and hydrothermal or solvothermal synthesis is the most typical preparation technology. There are also studies on microwave radiation synthesis or ultrasonic synthesis to prepare mesoporous silica, which could shorten the preparation time and reduce the cost. The pore-forming template agent in the precursor should be removed in the preparation process of mesoporous silica, and the inorganic framework structure be retained to form an ordered porous microstructure. The removal of the template is the key to the synthesis of mesoporous silica, usually including high-temperature calcination, solvent extraction, supercritical fluid extraction, microwave heating, and so on. It was shown that the larger the pore size of mesoporous silicon material, the better the blood coagulation effect and the more obvious the cell differentiation promoting function is. Therefore, the pore expansion technology is expected to improve the hemostatic properties of mesoporous silica materials. In addition, mesoporous silica could be compounded with metal ions, functional drugs and organic polymers, achieving various functions, such as antibacterial and promoting healing. The morphology, composition and surface modification of the mesoporous silica have a certain influence on its biosafety. The biosafety of the mesoporous silica can be optimized by material design and functional modifications to enhance its operability and practicability in the pre-hospital emergency.
This article reviews the rapid synthesis method of mesoporous silica, introduces the method of template removal, pore size control and function diversification during the preparation of mesoporous hemostatic materials, discusses the problem of biosafety of mesoporous silica as a hemosta-tic material. The preparation trend of porous silica materials and the prospects of future hemostatic applications are prospected.

Key words: mesoporous silica hemostatic material synthesis biological safety

发布日期: 2022-12-09

ZTFLH:

R318.08

通讯作者: ^*vanadium_1981@163.com

作者简介: 张卓然,2016年毕业于中国人民解放军第四军医大学,获得工学学士学位。现为军事科学院卫勤保障技术研究所硕士研究生,从事生物医用材料方向研究。
李钒,2016年博士毕业于军事科学院卫勤保障技术研究所,现为军事科学院卫勤保障技术研究所高级工程师。主要从事止血包扎材料、碳纳米材料在荧光标记、光能转化、光催化等方面的应用基础研究。以第一/通信作者发表学术论文30余篇,负责国家自然科学基金、天津市自然科学基金以及军队各类项目20余项。

引用本文:

张卓然, 李钒, 侯敏, 张媛媛, 丁晟, 魏晓慧, 林松. 介孔硅止血材料的研究现状及应用前景[J]. 材料导报, 2022, 36(23): 21010168-9.
ZHANG Zhuoran, LI Fan, HOU Min, ZHANG Yuanyuan, DING Sheng, WEI Xiaohui, LIN Song. Development of Mesoporous Silica Hemostatic Materials and Their Application Prospects. Materials Reports, 2022, 36(23): 21010168-9.

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http://www.mater-rep.com/CN/10.11896/cldb.21010168 或 http://www.mater-rep.com/CN/Y2022/V36/I23/21010168

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