Spinnability of Collagen-acetic Acid Mixing Solution and Mechanical Properties of Electrospinning Nanofiber Membrane Evaluation
CHEN Weiying, CHEN Zhenyong, YANG Zaijun, SHI Feng, LI Yunxiang
Collaboration Innovation Center for Tissue Repair Material Engineering Technology,College of Life Science, China West Normal University, Nanchong 637009, China
Abstract: Collagen have good absorbability and biocompatibility, thus it is widely used in biomedicine. However, the application of collagen nanofiber membrane from electrospinning technique is restricted in biomedical field, for its lower mechanical strength. In this study, the spinnability of type I collagen mixing solution with acetic acid was studied, and the mechanical properties of collagen nanofiber membrane were measured. The results showed that the collagen nanofiber membranes obtained by 10% mixed solution using 40% acetic acid were smooth. The average diameter of the fibers was (305.19±119.67) nm, and the layers of fibers were clear and created a continuous crossed net. The elastic modulus of the collagen nanofiber membrane of 0.2 mm was (749.22±107.72) MPa, and the average maximum tensile strength was (21.92±3.03) N. This indicated that collagen nanofiber membrane of 0.2 mm had good mechanical properties. The collagen nanofiber membrane from mixed solution of acetic acid/collagen has good appearance and mechanical strength. It can provide materials for further cell experiments, and be developed into medical patch materials, which can meet different clinical needs and have the value of practical application.