Preparation of Drug-loaded Electrospun Composite Nanofibers Based on Oxidation-reductive Amination Reaction Modified Alginate
YAN Huiqiong1,2, ZHANG Wei1, WANG Yue1, HE Songming1, ZHAO Rui1, LIAO Yue1, CHEN Xiuqiong1,2
1 Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Haikou 571158, China 2 Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China
Abstract: The amphiphilic alginate derivative (RAOA) was prepared via oxidative-reductive amination using the octylamine as a hydrophobic modifier. The structure and property of RAOA were characterized by FTIR,1H NMR, fluorescence spectrum and optical contact angle measuring instrument. Furthermore, the electrospinning of hydrophobically modified alginate derivative, RAOA, was studied by using PVA as a spinning auxiliary. The physical properties of RAOA/PVA spinning solution and the morphology of corresponding RAOA/PVA electrospun composite nanofibers were determined by optical contact angle measuring instrument, electrical conductivity meter, rheometer and scanning electron microscopy. And the loading and release properties of the electrospun composite nanofibers for hydrophobic ibuprofen were also investigated. Experimental results showed that the octylamine had successfully grafted onto the alginate molecular chains. The critical aggregation concentration measured by fluorescence spectrum was reduced to 0.43 g/L, which demonstrated the good amphipathy of RAOA. The oxidation-reductive amination modification of RAOA could not fundamentally change the spinnability of a single RAOA solution, but it could enhance the content of RAOA in RAOA/PVA electrospun composite nanofibers. The drug-loaded SA/PVA electrospun composite nanofibers would release rapidly at the beginning, but RAOA can effectively retard the drug release rate of ibuprofen, thus improving the sustained release performance of RAOA/PVA electrospun composite nanofibers.
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2020, Vol. 34 
