Construction of Alginate/Organic Montmorillonite Composite Hydrogel Beads Capable of Loading Hydrophobic Drugs Based on Wet-ball Milling Method Modified Montmorillonite and Their Release Properties
BAO Chaoling1,2, CHEN Xiuqiong1,2, LEI Mengyuan1, KE Chaoran1, ZHANG Wei1, YAN Huiqiong1,2, LIN Qiang1,2
1 Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Haikou 571158, China 2 Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China
Abstract: In order to construct a good organic hydrophobic drug carrier, the strong polarity and structural properties of montmorillonite were modified by wet ball-milling method using the nonionic surfactant, nonylphenolethoxylate (Np-10), as the modifier, to improve the montmorillonite's affi-nity for hydrophobic organic drug. Furthermore, the alginate/organic montmorillonite composite hydrogel bead (SA/OMMT HB) with slow and controlled release properties was prepared by the use of alginate as the coating material, under the exogenous cross-linking of calcium ions. The structure, properties and morphology of the prepared OMMT and SA/OMMT HB were characterized by FTIR, XRD, specific surface area and pore size analyzer, drug adsorption experiments, TGA and SEM. And the controlled release performance of the hydrophobic anti-inflammatory drug, ibuprofen, from SA/OMMT HB were also investigated. The experimental results showed that Np-10 was successfully inserted into the interlayer of Na-MMT under the action of wet ball-milling. The specific surface area of the modified OMMT increased from 67.69 m2/g to 208.31 m2/g. The results of the adsorption isotherm model fitting of ibuprofen by Na-MMT and OMMT showed that the affinity of OMMT for hydrophobic drugs was better than that of Na-MMT, which was more conductive to the loading of ibuprofen. In SA/OMMT HB, the OMMT sheet and alginate were combined by hydrogen bonding, which helped to improve the thermal stability of SA/OMMT HB. Moreover, the good affinity of OMMT to hydrophobic drug allowed SA/OMMT HB to exhibit good controlled release properties. According to the Peppas model equation fitting, the release process of ibuprofen from SA/OMMT HB belonged to the Non-Fickian diffusion mechanism, indicating that the drug itself diffuses and the swelling and degradation of the composite hydrogel beads jointly controlled the release rate of the drug.
包朝玲, 陈秀琼, 雷梦圆, 柯超然, 张威, 颜慧琼, 林强. 基于湿法球磨改性蒙脱土构建可负载疏水药物的海藻酸盐/有机蒙脱土复合凝胶微球及其释药性[J]. 材料导报, 2020, 34(10): 10171-10176.
BAO Chaoling, CHEN Xiuqiong, LEI Mengyuan, KE Chaoran, ZHANG Wei, YAN Huiqiong, LIN Qiang. Construction of Alginate/Organic Montmorillonite Composite Hydrogel Beads Capable of Loading Hydrophobic Drugs Based on Wet-ball Milling Method Modified Montmorillonite and Their Release Properties. Materials Reports, 2020, 34(10): 10171-10176.
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2020, Vol. 34 
