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材料导报  2022, Vol. 36 Issue (3): 21120187-6    https://doi.org/10.11896/cldb.21120187
  生物医用材料 |
pH响应型纳米药物用于化疗-光热协同治疗肿瘤
唐昭敏, 田维君
西南石油大学新能源与材料学院,成都 610500
Study on pH Responsive Nanomedicine in Chemo-photothermal Synergistic Therapy of Tumor
TANG Zhaomin, TIAN Weijun
School of New Energy and Materials, Southwest Petroluem University, Chengdu 610500, China
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摘要 化疗协同光热治疗(PTT)是提高肿瘤疗效的一种新型治疗方式。本研究拟合成一种亚细胞器靶向的近红外响应纳米药物Fe3O4@PDA-TPP/S2-PEG-hyd-DOX(Fe3O4-ATSPD)作为新的光热制剂,它可通过磁靶向增强肿瘤细胞的摄取,具有良好的光热稳定性和光热转化效率。在近红外光(NIR)照射下,光热剂多巴胺(PDA)产生光热效应,促使线粒体膜电位显著下降。同时,在内涵体/溶酶体低pH值环境下,Fe3O4-ATSPD释放偶联药物DOX进入细胞核损伤DNA,最终促使肿瘤细胞凋亡。本研究制备的纳米药物能有效整合诊断和治疗,为肿瘤治疗提供新的协同治疗策略。
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唐昭敏
田维君
关键词:  化疗  光热治疗  协同作用  近红外    
Abstract: Chemotherapy (CT) combined with photothermal therapy (PTT) is an effective combination for the treatment of tumor. Herein, we deve-loped a subcellular-targeted NIR-responsive nanomedicine Fe3O4@PDA-TPP/S2-PEG-hyd-DOX (abbreviated as Fe3O4-ATSPD) as a new photothermal agent, the intracellular uptake of which can be enhanced by magnetic targeting. Under the near-infrared (NIR) irradiation, the photothermal effect can be realized from the polydopamine photosensitizer, leading to a dramatic decrease in mitochondrial membrane potential. Simultaneously, the conjugated drugs released by low pH in endo/lysosome cause nucleus DNA damage and lead to apoptosis. This subcellular-targeted NIR-responsive nanomedicine with efficient integration of diagnosis and therapy, could significantly enhance cancer treatment by combination of chemotherapy and PTT.
Key words:  chemotherapy    photothermal therapy    synergistic effect    near-infrared
发布日期:  2022-02-10
ZTFLH:  R730.53  
基金资助: 国家自然科学基金(51803174)
通讯作者:  tl8687@163.com   
作者简介:  唐昭敏,西南石油大学新能源与材料学院讲师,博士,硕士研究生导师,主要从事新型功能材料用于肿瘤方面的研究。作为课题组负责人主持国家自然科学基金一项,以第一作者及通讯作者在Biomate-rials、Advanced Healthcare Materials、Acta Biomaterialia、Separation and Purification Technology 及European Journal of Pharmaceutics and Biopharmaceutics等高水平期刊上发表多篇SCI论文。
田维君,2019年6月毕业于乐山师范学院,获得工学学士学位。现为西南石油大学新能源与材料学院硕士研究生,主要从事新型功能材料用于肿瘤方面的研究。
引用本文:    
唐昭敏, 田维君. pH响应型纳米药物用于化疗-光热协同治疗肿瘤[J]. 材料导报, 2022, 36(3): 21120187-6.
TANG Zhaomin, TIAN Weijun. Study on pH Responsive Nanomedicine in Chemo-photothermal Synergistic Therapy of Tumor. Materials Reports, 2022, 36(3): 21120187-6.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.21120187  或          http://www.mater-rep.com/CN/Y2022/V36/I3/21120187
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