荧光水凝胶传感器及其传感响应机制研究进展

doi:10.11896/cldb.21010130

材料导报

2023, Vol. 37

Issue (5): 21010130-8 https://doi.org/10.11896/cldb.21010130

高分子与聚合物基复合材料

荧光水凝胶传感器及其传感响应机制研究进展

饶春兴, 廖静文, 张雪慧, 武晓刚, 王艳芹^*, 陈维毅

太原理工大学生物医学工程学院, 太原 030024

Fluorescent Polymeric Hydrogels Sensors and Their Sensing Mechanisms:a Review

RAO Chunxing, LIAO Jingwen, ZHANG Xuehui, WU Xiaogang, WANG Yanqin^*, CHEN Weiyi

College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China

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摘要荧光水凝胶是一类具有三维交联网络、荧光发射性能的新型高分子复合材料,能够在外界目标分析物的刺激下发生荧光强度或荧光发射颜色的改变。因此,荧光水凝胶能够作为定量检测目标分析物浓度的重要工具,并且表现出良好的荧光稳定性与检测便携性。近年来,研究人员开发出了多种基于不同类型响应机制的荧光水凝胶传感探针,并应用于各种类型目标分析物的检测。在传统的荧光水凝胶传感器的设计过程中,大多数是基于目标分析物与水凝胶内部的荧光材料间高度的特异性识别功能,这需要目标分析物与荧光材料之间的高度一一对应关系,限制了此类荧光水凝胶传感器的检测广泛性。然而,通过间接性作用构建的荧光水凝胶能够引入一个中间媒介作为桥梁进一步实现各类目标分析物的特异性识别与响应。该种级联响应目标分析物的方式打破了传统荧光水凝胶传感器的局限性。本文根据荧光水凝胶传感体系构建过程中所涉及到的信号响应机制,将荧光水凝胶传感器分为三大类,主要包括直接响应型、竞争性响应型、非竞争性响应型,这对于启发人们构建新型荧光水凝胶传感器具有重要的参考意义。最后,对荧光水凝胶传感器在检测领域所面临的机遇与挑战进行了总结与展望。

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关键词: 水凝胶荧光传感器响应机制竞争性响应非竞争性响应

Abstract: Fluorescent hydrogel is a new type of polymer composite with three-dimensional cross-linked networks and fluorescence emission properties. The fluorescence intensity or fluorescence emission color can change under the stimulation of external target analytes. Hence, fluorescent hydrogel can serve as an essential tool for the quantitative detection of target analyte concentration, while also offering good fluorescence stability and detection portability. In recent years, researchers have developed various fluorescent hydrogel sensing probes based on different types of response mechanisms, and have applied them in the detection of various types of target analytes. The design of traditional fluorescent hydrogel sensors is typically based on a highly specific recognition function between the target analytes and fluorescent material inside the hydrogel, which requires a high one-to-one correspondence between the target analytes and fluorescent material, limiting the detection range of such fluorescent hydrogel sensors. However, fluorescent hydrogels based on indirect interaction can introduce an intermediate medium as a bridge to further achieve specific recognition and response to various target analytes. This cascade response to target analytes overcomes the limitations of conventional fluorescent hydrogel sensors. Based on the signal response mechanisms involved in the fabrication of fluorescent hydrogel sensing systems, the fluorescent hydrogel sensors are classified into three major categories in this paper: direct response, competitive response, and non-competitive response. This paper provides important insights for the fabrication of new fluorescent hydrogel sensors. Finally, the prospects and challenges associated with fluorescent hydrogel sensors in the field of detection are summarized and discussed.

Key words: hydrogel fluorescent sensor responsive mechanism competitive responsive non-competitive responsive

出版日期: 2023-03-10 发布日期: 2023-03-14

ZTFLH:

O63

基金资助: 国家自然科学基金 (1217224;11972242);山西省高等学校科技创新项目(2019L0169);山西省自然科学基金面上项目(20210302123158);山西浙大新材料与化工研究院技术开发项目(2022SX-TD023)

通讯作者: ^*王艳芹,太原理工大学生物医学工程学院副教授、硕士研究生导师。2013年毕业于南开大学,获得理学博士学位。目前主要研究方向为生物医用高分子材料、纳米荧光生物传感器设计。主持国家自然科学青年基金、山西省青年基金、面上项目等科研项目,以第一或通信作者身份发表SCI学术论文26篇。wangyanqin@tyut.edu.cn

作者简介: 饶春兴,2018年6月毕业于湖北科技学院,获得工学学士学位。现为太原理工大学生物医学工程学院硕士研究生。目前主要研究方向为生物医用高分子材料的制备以及力学、荧光性能的分析。

引用本文:

饶春兴, 廖静文, 张雪慧, 武晓刚, 王艳芹, 陈维毅. 荧光水凝胶传感器及其传感响应机制研究进展[J]. 材料导报, 2023, 37(5): 21010130-8.
RAO Chunxing, LIAO Jingwen, ZHANG Xuehui, WU Xiaogang, WANG Yanqin, CHEN Weiyi. Fluorescent Polymeric Hydrogels Sensors and Their Sensing Mechanisms:a Review. Materials Reports, 2023, 37(5): 21010130-8.

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http://www.mater-rep.com/CN/10.11896/cldb.21010130 或 http://www.mater-rep.com/CN/Y2023/V37/I5/21010130

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