Abstract: Cardiovascular disease is the leading cause of death worldwide. There are nearly 300 million patients with cardiovascular diseases in China, and the number of deaths is about 3 million each year, accounting for 45% of the total deaths from all diseases. The main cardiovascular di-seases are coronary heart disease and heart valve disease. At present, due to its low risk, fast operation, small trauma and fast recovery, minimally invasive interventional therapy is the most effective means in the treatment of cardiovascular diseases. Therefore, minimally invasive interventional cardiovascular devices have become hot topics in this field. With the steady and rapid development of the global medical device market, cardiovascular devices are the second largest market in the medical device industry. Fully biodegradable stents can overcome the potential problems of chronic inflammation, late thrombosis and long-term antiplatelet treatment caused by current market available drug eluting metallic stents, which is a key research field of minimally invasive and interventional cardiovascular medical device. Fully biodegradable stents can be divided into fully degradable polymeric stents and fully degradable metallic stents. In recent years, FDA has approved some minimally invasive interventional heart valve products. Chinese companies also keep up with the pace, related products have been approved by CFDA. However, the existing valves still have drawbacks such as durability,calcification,and toxicity, etc.. Therefore, the research and development of heart valves with better properties have become the trend and frontier of minimally invasive and interventional cardiovascular medical devices. In this paper, the current research status and research frontier of two representative products, including the biodegradable vascular stent and transcatheter heart valve implantation products, are described in detail. The existing problems and challenges in the research and product deve-lopment are also discussed. Finally, the development direction and future of this research field are also prospected. We hope the content of this review paper could provide reference for the relevant researchers.
杨立, 罗日方, 雷洋, 王云兵. 微创介入全降解血管支架和心脏瓣膜国内外研发现状与研究前沿[J]. 材料导报, 2019, 33(1): 40-47.
YANG Li, LUO Rifang, LEI Yang, WANG Yunbing. Frontier Research and Development of Minimally Invasive and Interventional Fully Biodegradable Stent and Heart Valve. Materials Reports, 2019, 33(1): 40-47.
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2019, Vol. 33 
