1 College of Materials Science and Engineering, Sichuan University of Science and Engineering,Zigong 643000, Sichuan, China 2 State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China
Abstract: Hydrogel is a three-dimensional porous network structure polymer cross-linked by a hydrophilic polymer, which swells in an aqueous solution and is insoluble in water. Due to the unique physical or chemical properties, such as biocompatibility and bioavailability, and the advantages of degradability, hydrophilicity and so on, hydrogel is widely used in the fields of drug release, targeted delivery, tissue engineering, etc. Smart response hydrogels will perceive and respond to small changes and stimuli in the body environment, such as temperature-sensitive hydrogels, pH-sensitive hydrogels, light-sensitive hydrogels, magnetic-sensitive hydrogels, ions-sensitive hydrogels, etc. Among them, pH-sensitive hydrogel is the most common hydrogel, which can produce morphological and structural changes in different pH environments. As a new type of drug delivery carrier material, it has received more and more attention in recent years. The pH-sensitive hydrogel can adjust its own properties or structure according to the different pH values of the human environment, form a semi-solid part of the body, have good adhesion, and be capable of targeted drug delivery.The polymeric materials of pH-sensitive hydrogels mainly include natural polymer materials and synthetic materials. Natural polymer materials include chitosan, carboxymethyl cellulose, and sodium alginate, while artificial synthetic materials include polyacrylic acid, polymethacrylic acid and so on. The preparation methods of pH-sensitive hydrogel mainly include physical cross-linking polymerization method and chemical cross-linking polymerization method. This article reviews the research progress of pH-sensitive hydrogel, and summarizes the latest advances in the common polymer materials, preparation methods, and applications of pH-sensitive hydrogel in the field of drug delivery. The research and application prospects of these are also summarized. A prospect and a reference for the later research and application of pH-sensitive hydrogel are provided.
1 Li Z, Huang J, Wu J. Biomaterials Science, 2021, 9(3), 574. 2 Ahmed E M. Journal of Advanced Research,2015,6(2), 105. 3 Marcombe R, Cai S, Hong W, et al. Soft Matter, 2010, 6(4), 784. 4 Su C Y, Ho H O, Chen Y C,et al. Scientific Reports, 2018, 8(1), 1. 5 Akala E O, Kopečková P, Kopečk J. Biomaterials, 1998, 19(11-12), 1037. 6 Chen T, Li S, Zhu W, et al. Journal of Microencapsulation, 2019, 36(1), 96. 7 Yu S, Zhang X, Tan G, et al. Carbohydrate Polymers, 2017, 155, 208. 8 Guo B L, Yuan J F, Gao Q Y. Polymer International, 2008, 57(3), 463. 9 Aycan D, Alemdar N. Carbohydrate Polymers, 2018, 184, 401. 10 Barkhordari S, Alizadeh A. Polymer Bulletin, DOI:10/1007/s00289-021-03761-3. 11 Zennifer A, Senthilvelan P, Sethuraman S, et al. Carbohydrate Polymers, 2021, 256, 117561. 12 Jeddi M K, Mahkam M. International Journal of Biological Macromolecules, 2019, 135, 829. 13 Supramaniam J, Adnan R, Kaus N H M, et al. International Journal of Biological Macromolecules, 2018, 118, 640. 14 Rasoulzadeh M, Namazi H. Carbohydrate Polymers, 2017, 168, 320. 15 Sun X, Liu C, Omer A M, et al. International Journal of Biological Macromolecules, 2019, 128, 468. 16 Venkatesan J, Bhatnagar I, Manivasagan P, et al. International Journal of Biological Macromolecules, 2015, 72, 269. 17 Chang S,Qin D, Yan R,et al. ACS Omega, 2021, 6(2), 1119. 18 Zou Z, Zhang B, Nie X, et al. RSC Advances,2020, 10(65), 39722. 19 Mertins O, Mathews P D. Nanomaterials, 2020, 10(5), 963. 20 Mukhopadhyay P, Sarkar K, Bhattacharya S, et al. Carbohydrate Polymers, 2014, 112, 627. 21 Wu H, Jin H,Wang C, et al. ACS Applied Materials & Interfaces, 2017, 9(11), 9426. 22 Rattanawongwiboon T, Ghaffarlou M, Sütekin S D, et al. Colloid and Polymer Science, 2018, 296(9), 1599. 23 Li Z,Huang J, Wu J. Biomaterials Science, 2021, 9(3), 574. 24 Xu Q, Huang W, Jiang L, et al. Carbohydrate Polymers, 2013, 97(2), 565. 25 Xue B,Kozlovskaya V,Liu F,et al. ACS Applied Materials & Interfaces, 2015, 7(24), 13633. 26 Luo Y L, Xu F, Feng Q S, et al. Journal of Biomedical Materials Research Part B, 2010, 92(1), 243. 27 Varaprasad K, Raghavendra G M, Jayaramudu T, et al. Materials Science and Engineering C, 2017, 79, 958. 28 Ye X, Li X, Shen Y, et al. Polymer, 2017, 108, 348. 29 Zhang M, Chen G, Lei M, et al. International Journal of Biological Macromolecules, 2021, 182, 385. 30 Wang M,Zang Y, Hong K, et al. International Journal of Biological Macromolecules, 2021, 192, 684. 31 Suhail M, Wu P C, Minhas M U. Journal of Saudi Chemical Society, 2021, 25(4), 101212. 32 Pridgen E M, Alexis F, Farokhzad O C. Expert Opinion on Drug Delivery, 2015, 12(9), 1459. 33 Cao S, Xu S, Wang H, et al. AAPS PharmSciTech, 2019, 20(5), 1. 34 Yang J, Chen J, Pan D, et al. Carbohydrate Polymers, 2013, 92(1), 719. 35 Karnoosh-Yamchi J, Rahmati-Yamchi M, Akbarzadeh A, et al. Artificial Cells, Nanomedicine and Biotechnology, 2017, 45(6), 1222. 36 Chen T, Li S, Zhu W, et al. Journal of Microencapsulation, 2019, 36(1), 96. 37 Arafa A A, Nada A A, Ibrahim A Y, et al. International Journal of Biological Macromolecules, 2021,182, 1820. 38 Guo T, Kang X, Ren S, et al. Nanomaterials, 2021, 11(11), 2812. 39 Sun Y, Nan D, Jin H, et al. Polymer Testing, 2020, 81, 106283. 40 Liang Y, Zhao X, Ma P X, et al. Journal of Colloid and Interface Science, 2019, 536, 224. 41 Qu J, Zhao X, Ma P X, et al. Acta Biomaterialia, 2018, 72, 55. 42 Dhuria S V, Hanson L R, Frey II W H. Journal of Pharmaceutical Sciences, 2010, 99(4), 1654. 43 Edsman K, Carlfors J,Petersson R. European Journal of Pharmaceutical Sciences, 1998, 6(2), 105. 44 Elkomy M H, El-Menshawe S F, Ali A A, et al. Drug Delivery and Translational Research, 2018, 8(1), 165. 45 Chen Y, Cheng G, Hu R, et al. AAPS PharmSciTech, 2019 ,20(7), 1. 46 Li X Y, Zhang Z, Chen H. International Journal of Pharmaceutics, 2013, 448(1), 96. 47 Zhang Z, Yu J, Zhou Y, et al. Colloids and Surfaces B: Biointerfaces, 2018, 164, 436.