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材料导报  2021, Vol. 35 Issue (Z1): 507-512    
  高分子与聚合物基复合材料 |
基于中性粒细胞的分子影像探针研究进展
李曼曼, 冯峰
南通大学附属肿瘤医院,南通 226361
Research Progress of Molecular Imaging Probes Based on Neutrophils
LI Manman, FENG Feng
Affiliated Tumor Hospital of Nantong University, Nantong 226361, China
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摘要 中性粒细胞是最丰富的循环白细胞,是抵御入侵病原体的第一道防线,也是先天免疫系统的关键组成部分。然而,中性粒细胞在各种自身免疫和炎性疾病中也导致组织损伤,并在癌症进展中起重要作用。鉴于多种疾病与中性粒细胞的复杂关系,使中性粒细胞成为诊断与治疗干预的重要靶标。分子影像是指对活体目标生物分子进行定量、非侵入性、重复性的成像,并监测活体生物的相关生物学过程。本文将基于中性粒细胞活细胞探针及中性粒细胞仿生纳米探针在炎症、肿瘤的成像诊断及治疗方面进行综述。
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李曼曼
冯峰
关键词:  中性粒细胞  分子影像  炎症  癌症  纳米粒  探针    
Abstract: Neutrophils are the most abundant circulating leukocytes and the first line of defense against invading pathogens, and are the key component of the innate immune system. However, neutrophils also cause tissue damage in various autoimmune and inflammatory diseases and play an important role in cancer progression. Due to the complex relationship between various diseases and neutrophils, neutrophils have become an exciting target for therapeutic intervention. Molecular imaging refers to the quantitative, non-invasive and repetitive imaging of biological molecules in vivo, and monitoring the related biological processes of living organisms. This review will focus on two aspects: drug delivery with neutrophils as carrier and designing specific probes to target neutrophils.
Key words:  neutrophils    molecular imaging    inflammation    cancer    nanoparticles    probe
                    发布日期:  2021-07-16
ZTFLH:  R318.08  
  R314  
基金资助: 吴阶平医学基金会(320.6750)
通讯作者:  drfengfeng@163.com   
作者简介:  李曼曼,原工作于盐城市第一人民医院影像科,主治医师,现为南通大学医学院影像医学与核医学专业一年级研究生。在冯峰教授指导下进行分子影像研究。冯峰,2000年毕业于南京医科大学,2013年复旦大学博士毕业,南通大学附属肿瘤医院影像科主任,主任医师,硕士研究生导师。中华医学会放射学分会感染影像全国青年委员,中国抗癌协会肿瘤影像专业委员会全国委员,江苏省放射学会磁共振学组委员,江苏省医师协会放射学分会呼吸学组委员,南通市226第三层次人才,南通市医学会放射学会副主任委员,南通市抗癌协会肿瘤影像专业主任委员。研究方向为胸部疾病影像学诊断,重点是肺癌的诊断与鉴别诊断,以及分子影像研究。以第一作者、通讯作者发表论文40余篇,核心期刊20余篇,并参编专著4部。
引用本文:    
李曼曼, 冯峰. 基于中性粒细胞的分子影像探针研究进展[J]. 材料导报, 2021, 35(Z1): 507-512.
LI Manman, FENG Feng. Research Progress of Molecular Imaging Probes Based on Neutrophils. Materials Reports, 2021, 35(Z1): 507-512.
链接本文:  
http://www.mater-rep.com/CN/  或          http://www.mater-rep.com/CN/Y2021/V35/IZ1/507
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