多重响应纳米凝胶的一步回流沉淀聚合法制备及性能表征

材料导报

2021, Vol. 35

Issue (Z1): 513-517

高分子与聚合物基复合材料

多重响应纳米凝胶的一步回流沉淀聚合法制备及性能表征

沈玉琳^1,2, 李婷^1,2, 叶超宇^1,2, 王小美^1,2, 吕毅^1,2, 潘在蘩^1,2, 王昭^1,2

1 金陵科技学院材料工程学院,南京 211106
2 视光材料与技术南京市重点实验室,南京 211106

Preparation and Characterization of Multi-response Nanogels by Reflux Precipitation Polymerization

SHEN Yulin^1,2, LI Ting^1,2, YE Chaoyu^1,2, WANG Xiaomei^1,2, LYU Yi^1,2, PAN Zaifan^1,2, WANG Zhao^1,2

1 School of Materials Engineering, Jinling Institute of Technology, Nanjing 211106,China
2 Nanjing Key Laboratory of Optometric Materials and Technology, Nanjing 211106,China

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摘要以甲基丙烯酸(MAA)和N-异丙基丙烯酰胺(NIPAM)为单体,通过一步回流沉淀聚合法制得了具有温度、pH和还原多重响应的单分散P(MAA-co-NIPAM)纳米凝胶。利用动态光散射仪(DLS)、透射电子显微镜(TEM)对纳米凝胶的尺寸和形貌进行了表征,进一步研究了纳米凝胶的多重刺激响应性及其药物负载行为和细胞毒性。结果表明,通过调节反应单体、交联剂和引发剂的投料量,可以得到系列不同粒径的单分散纳米凝胶,代表性纳米凝胶具有良好的温度、pH和还原响应性,能够有效负载抗肿瘤药物阿霉素(DOX),且细胞相容性良好,有利于作为智能药物输送载体应用。

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	沈玉琳
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	潘在蘩
	王昭

关键词: 纳米凝胶回流沉淀聚合多重响应药物负载阿霉素

Abstract: P(MAA-co-NIPAM) nanogels with multi-responsiveness were prepared by Reflux Precipitation Polymerization using methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) as monomers. The size and morphology of the nanogels were characterized by dynamic light scatte-ring (DLS) and transmission electron microscopy (TEM), and their multiple stimulus responsiveness, drug loading behavior and cytotoxicity were further studied. Results indicate that monodisperse nanogels with different particle sizes were obtained by adjusting the feeding ratio. The nanogels showed good thermo, pH and reduction responsiveness, as well as high DOX loading efficiency and good cytocompatibility, beneficial for using as smart drug delivery carriers.

Key words: nanogel reflux precipitation polymerization multi-responsive drug delivery doxorubicin

发布日期: 2021-07-16

ZTFLH:

O63

基金资助: 江苏省自然科学基金(BK20190113), 江苏省大学生创新创业训练计划(202013573066Y)

通讯作者: wangzhao@jit.edu.cn

作者简介: 沈玉琳,金陵科技学院本科在读,主要从事生物医用材料的合成及性能研究。王昭,金陵科技学院讲师。2016年博士毕业于中国科学院上海有机化学研究所,高分子化学与物理专业。2016至2018年在复旦大学高分子科学系从事博士后研究。2018年至今在金陵科技学院材料工程学院任教。主要研究方向为高分子药物输送体系的设计及制备。以第一作者在国内外学术期刊上发表SCI论文十余篇,获江苏省科学技术奖三等奖一项,目前主持江苏省自然科学基金项目一项。

引用本文:

沈玉琳, 李婷, 叶超宇, 王小美, 吕毅, 潘在蘩, 王昭. 多重响应纳米凝胶的一步回流沉淀聚合法制备及性能表征[J]. 材料导报, 2021, 35(Z1): 513-517.
SHEN Yulin, LI Ting, YE Chaoyu, WANG Xiaomei, LYU Yi, PAN Zaifan, WANG Zhao. Preparation and Characterization of Multi-response Nanogels by Reflux Precipitation Polymerization. Materials Reports, 2021, 35(Z1): 513-517.

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http://www.mater-rep.com/CN/ 或 http://www.mater-rep.com/CN/Y2021/V35/IZ1/513

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