柔性电子在糖尿病诊断、治疗及护理中的应用综述

doi:10.11896/cldb.19100178

材料导报

2020, Vol. 34

Issue (1): 1126-1134 https://doi.org/10.11896/cldb.19100178

柔性电子在糖尿病诊断、治疗及护理中的应用综述

宋江^1,,王腾蛟^1,2,,冯涛^1,2,CHAN Siew Yin^1,2,荣帆¹,李鹏^1,2,黄维^1,2,

1 西北工业大学柔性电子研究院,西安 710072
2 西安生物医学材料与工程研究院,西安 710072

Applying Flexible Electronics in the Diagnosis, Treatment and Nursing Care for Diabetes Mellitus: a Review

SONG Jiang^1,,WANG Tengjiao^1,2,,FENG Tao^1,2,CHAN Siew Yin^1,2,RONG Fan¹,LI Peng^1,2,HUANG Wei^1,2,

1 Xi'an Institute of Flexible Electronics,Northwestern Polytechnical University,Xi'an 710072,China
2 Xi'an Institute of Biomedical Materials and Engineering,Northwestern Polytechnical University,Xi'an 710072,China

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摘要糖尿病是生活中常见的一种慢性病,其特征是血液中存在高浓度的葡萄糖。血糖浓度过高会导致代谢紊乱,并衍生一系列的并发症,严重降低了患者的生活质量,病情发展严重还会导致残疾甚至死亡。随着智能终端和移动互联网的普及,柔性电子产品因为具有质量轻、可拉伸和延展性好等独特的优势,近年来逐渐进入人们的日常生活,并被应用在医疗设施中,尤其是在对慢性疾病如糖尿病的诊断、治疗和护理等方面展现出极大的应用潜力。
糖尿病患者需要定期检测血液中的葡萄糖水平,长期使用相关药物进行治疗与控制,由糖尿病引起的各种并发症也需要长期进行监控和护理。传统的糖尿病诊断方法形式单一,不能连续、实时地检测血液中的葡萄糖水平,会对患者造成创伤或延误患者最佳治疗时间。此外,对糖尿病患者的后期护理机制不健全,加上目前的护理设备相对落后,导致患者病情迅速发展。
柔性电子通过结合传感器技术集成为可穿戴柔性电子设备,能够连续、实时地以无创或微创的形式来检测体内葡萄糖水平。可穿戴柔性电子设备通过集成给药装置和无线通信设备,可以智能化地控制药物剂量以及给药治疗,并对糖尿病患者进行健康监测和运动辅助。因此,可穿戴柔性电子设备的出现为糖尿病的诊断、治疗和护理提供了新的途径,成为糖尿病个体化管理最理想的平台。
本文综述了近几年来可穿戴柔性电子设备在糖尿病诊断、治疗和护理中的应用和进展,分析了可穿戴柔性电子设备发展过程中所面临的挑战以及潜在的应用前景。

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关键词: 柔性电子可穿戴设备糖尿病血糖检测健康护理生物传感

Abstract: Diabetes is a common chronic metabolic disease characterized by high glucose concentrations in the blood, adversely affecting the health and diminishing the qualities of life of patients. In addition, diabetes can also cause a series of complications, rendering it difficult to restore the health of patients with medication alone. The development of these complications may lead to disability or even death. With the rise of artificial intelligence and Internet of Things, flexible electronics has been gradually employed for the treatment of diabetes in recent years due to its unique advantages such as being lightweight, stretchable, or bendable.
To treat and control the development of diabetes, patients need to regularly detect glucose content in the blood and take medication over a long term period. Traditional methods of diagnosing diabetes are unable to detect the glucose level in the blood continuously and in real time, causing trauma and delaying the best treatment time for patients. Due to inadequate nursing mechanism and backward nursing equipment, the conditions of patients may worsen rapidly.
Flexible electronics are integrated into wearable flexible electronic devices through integration with sensing technologies. These equipment can be directly worn on the body, and are able to detect the glucose level in the body continuously and in real time through non-invasive or minimally invasive detection methods. By integrating drug delivery devices and wireless communication equipment, the setup can intelligently control drug dosage, render drug treatment, as well as carry out real-time health monitoring and exercise assistance for diabetic patients. Therefore, wearable flexible electronic devices provide new ways for diagnosis, treatment, and nursing care of diabetes, and has become the most ideal platform for individualized management of diabetes.
This paper reviews the applications of flexible wearable devices in the diagnosis, treatment, and nursing care for diabetes in recent years. The challenges faced in the development of flexible wearable devices are also discussed. Progress in the area of flexible wearable devices may potentially alleviate problems faced by diabetic patients, thereby improving their quality of life.

Key words: flexible electronics wearable devices diabetes glucose detection health care biosensing

发布日期: 2020-01-15

ZTFLH:

TN04

基金资助: 国家重点研发计划(2018YFC1105402);国家自然科学基金面上项目(21875189);陕西省创新人才推进计划(2019KJXX-064);陕西省自然科学基础研究计划青年项目(2019JQ-157);中央高校基本科研业务费(G2018KY0305;G2018KY0307)

通讯作者: iamtjwang@nwpu.edu.cn; iamwhuang@nwpu.edu.cn

作者简介: 宋江,2019年毕业于中国石油大学(华东),获光电信息科学与工程学士学位,现为西北工业大学柔性电子研究院硕士研究生。目前主要研究方向为柔性生物电子器件。
王腾蛟,西北工业大学柔性电子研究院(西安生物医学材料与工程研究院)副教授。2010年于北京化工大学获得高分子科学与工程学士学位,2016年于日本大阪大学获得高分子材料博士学位,2016-2018年在美国阿肯色大学进行博士后研究工作。主要从事聚合物生物医学材料的制备和应用,科研经历涉足于高分子化学、纳米药物和有机化学等领域。王腾蛟副教授在抗菌、抗癌、伤口愈合等方面已经累计发表包括Polymer Chemistry,Langmuir,Macromolecular Bioscience等SCI收录论文13篇。
黄维,中国科学院院士,俄罗斯科学院外籍院士、名誉博士,亚太材料科学院院士、东盟工程与技术科学院外籍院士、巴基斯坦科学院院士,西北工业大学常务副校长,教授、博导,有机电子学/柔性电子学家。教育部“长江学者”特聘教授,国家杰出青年科学基金获得者,“千人计划”(溯及既往)国家特聘专家,科技部“973”项目首席科学家。亚太地区工程组织联合会(FEIAP)主席、英国谢菲尔德大学名誉博士、英国皇家化学学会会士、美国光学学会会士、国际光学工程学会会士,中国科协常委,中国化学会副理事长,中国化工学会副理事长,Research、npj Flexible Electronics和Advanced Materials等国际权威学术杂志主编或(顾问)编委。长期从事有机光电、柔性电子等相关领域的研究,并取得了大量系统性、创新性的研究成果,以第一或通讯作者身份在Nature、Nature Materials、Nature Photonics、Nature Nanotechnology、Nature Electronics、Nature Communications、Advanced Materials、Journal of the American Chemical Society等SCI学术期刊发表研究论文760余篇,H因子为121,国际同行引用70 000余次,是材料科学与化学领域全球高被引学者,获授权美国、新加坡和中国等国发明专利380余项,出版了《有机电子学》《生物光电子学》《有机薄膜晶体管材料器件和应用》《OLED显示技术》等学术专著。曾获国家自然科学奖二等奖和何梁何利基金科技进步奖等奖励,成果入围中国高等学校十大科技进展。

引用本文:

宋江,王腾蛟,冯涛,CHAN Siew Yin,荣帆,李鹏,黄维. 柔性电子在糖尿病诊断、治疗及护理中的应用综述[J]. 材料导报, 2020, 34(1): 1126-1134.
SONG Jiang,WANG Tengjiao,FENG Tao,CHAN Siew Yin,RONG Fan,LI Peng,HUANG Wei. Applying Flexible Electronics in the Diagnosis, Treatment and Nursing Care for Diabetes Mellitus: a Review. Materials Reports, 2020, 34(1): 1126-1134.

链接本文:

http://www.mater-rep.com/CN/10.11896/cldb.19100178 或 http://www.mater-rep.com/CN/Y2020/V34/I1/1126

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