遇湿粘附多孔止血海绵的设计、制备及性能评价

doi:10.11896/cldb.23120228

材料导报

2025, Vol. 39

Issue (5): 23120228-10 https://doi.org/10.11896/cldb.23120228

高分子与聚合物基复合材料

遇湿粘附多孔止血海绵的设计、制备及性能评价

盖长智^1,2, 方辉³, 潘钊^1,2,*, 董良^1,2,*

1 浙江工业大学材料科学与工程学院,杭州 310014
2 中国科学院杭州医学研究所,杭州 310022
3 安徽医科大学口腔医学院,合肥 230032

Design, Preparation and Performance Evaluation of Porous Wet-Adhesive Hemostasis Sponge

GAI Changzhi^1,2, FANG Hui³, PAN Zhao^1,2,*, DONG Liang^1,2,*

1 School of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China
2 Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
3 Stomatological College, Anhui Medical University, Anhui 230032, China

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摘要肝脏、肾脏等器官因血管密集、质地脆弱,在受到创伤后出血常难以控制,且组织易二次受创,导致外科止血难度大。无需按压即可遇湿粘附固定,同时实现物理封堵和促进凝血,是应对不可压迫伤口出血的止血材料应具备的关键性能。本工作拟设计并制备一种新型止血材料,取向多孔海绵结合聚合物交联多孔网络,通过冷冻干燥制得遇湿粘附多孔止血海绵。该材料有效整合了取向壳聚糖海绵的快速吸血、凝血能力,疏松多孔粘性基质层的遇湿粘附能力。微观结构分析验证了材料的分层、多孔结构,双层海绵展示出优异的力学性能和生物粘附效果。材料生物相容性良好,高达85%的孔隙率及近500%的采血率赋予材料快速吸血并促进凝血的性能。体外模拟止血实验证实该海绵具有优异的止血效果,在处理肝脏、肾脏等脆弱器官出血的体内环境中具有广阔的应用前景,这项工作也为粘附性止血材料的开发开辟了新的途径和方法。

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	盖长智
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关键词: 不可压迫伤口止血物理封堵促进凝血止血海绵

Abstract: Organs such as the liver and kidneys have dense blood vessels and fragile textures, so it is often difficult to control bleeding after trauma, and the tissues are prone to secondary trauma, making surgical hemostasis difficult. Essential characteristics of hemostatic materials designed for non-compressible wounds include the capacity for wet adhesion and fixation without compression, coupled with concurrent physical sealing and facilitation of coagulation. The objective of this study was to engineer a novel hemostatic material, encompassing an oriented porous sponge in conjunction with a polymer cross-linked porous network, culminating in a viscous, double-layered hemostatic sponge produced via lyophilization. This composite material adeptly merges the rapid hemostatic efficacy and coagulative functionality of the oriented chitosan sponge with the enhanced wet-adhesive properties of a porous, viscous matrix. Through microstructural examination, the material’s stratified and porous architecture was authenticated. The double-layered sponge demonstrated superior mechanical robustness and bio-adhesive capabilities. Furthermore, it exhibited commendable biocompatibility, evidenced by a porosity reaching 85% and an impressive blood absorption rate approaching 500%, thereby facilitating expeditious blood uptake and coagulation. In vitro hemostasis simulation experiments have confirmed that the sponge possesses excellent hemostatic effects, showing broad application prospects in the in vivo environment for managing bleeding in delicate organs such as the liver and kidneys. This work also paves new avenues and methods for the development of adhesive hemostatic materials.

Key words: non-compressible wound hemorrhage control physical sealing coagulation hemostasis hemostasis sponge

出版日期: 2025-03-10 发布日期: 2025-03-18

ZTFLH:	TB332
	R605.972

基金资助: 国家自然科学基金青年科学基金(22305254);中国博士后科学基金(2021M703067)

通讯作者: ^*潘钊,中国科学院基础医学与肿瘤研究所特聘副研究员。主要从事仿生水凝胶组织修复材料的创新设计与制备、柔性生物电子在组织修复中的应用等方向的研究。panzhao@him.cas.cn
董良,中国科学院杭州医学研究所特聘研究员。主要从事仿生生物材料的功能化设计、生物医学应用与生物效应研究;多功能生物矿化材料的制备及在肿瘤治疗、组织修复、影像诊断、免疫调节中的应用。dongliang@him.cas.cn

作者简介: 盖长智,现为浙江工业大学材料学院硕士研究生,在董良研究员、潘钊副研究员的指导下进行研究。目前主要研究领域为生物医用材料。

引用本文:

盖长智, 方辉, 潘钊, 董良. 遇湿粘附多孔止血海绵的设计、制备及性能评价[J]. 材料导报, 2025, 39(5): 23120228-10.
GAI Changzhi, FANG Hui, PAN Zhao, DONG Liang. Design, Preparation and Performance Evaluation of Porous Wet-Adhesive Hemostasis Sponge. Materials Reports, 2025, 39(5): 23120228-10.

链接本文:

https://www.mater-rep.com/CN/10.11896/cldb.23120228 或 https://www.mater-rep.com/CN/Y2025/V39/I5/23120228

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