A Skin Model Simulating Humidity Response Features and Mechanical Properties of Human Skin
CHEN Jingmin1,2, LI Jiusheng2, CHEN Jinyang1, ZENG Xiangqiong2
1 School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444 2 Laboratory for Advanced Lubricating Materials, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210
Abstract: High-quality artificial skin model (ASM) plays a critical role in developing skin contacted materials, accordingly, the great efforts have been paid in the research of ASM. In this study, an artificial skin model was constructed by chitosan (CTS) hydrogel and polydimethylsiloxane (PDMS), aiming at simulating the humidity response and mechanical properties of human skin. Furthermore, the impact of the mass ratio of CTS and PDMS, and the content of curing agent on the performance of ASM were investigated. It was found that the increase of curing agent content contributed to the raise of hydration level and swelling rate of the ASM. The prepared ASM would well simulated diverse hydration degrees of human skin with mass ratio of the curing agent to the polydimethylsiloxane of less than 1∶20. The results of UST test indicated that the reduction of curing agent content would lead to the decline of elastic modulus of ASM. When the mass ratio of curing agent and PDMS was reduced to 1∶50, the ASM exhibited similar variation behaviors of elastic modulus to depth with human skin in inner forearm. Additionally, the elastic modulus of dry ASM was higher than that of wet ASM, which was consistent with the characteristics of human skin.
作者简介: 陈景民,2019年6月毕业于上海大学,获得工程硕士学位。于2017年5月至2019年6月在中国科学院上海高等研究院联合培养学习,主要从事仿生材料领域的研究。 曾祥琼,中国科学院上海高等研究院,研究员、博士研究生导师。上海交通大学材料学博士。2006—2010年在强生消费品集团公司开展皮肤护理技术研究,任职至资深科学家;2011—2015年在荷兰特温特大学表面技术与摩擦学实验室担任助理教授,开展皮肤摩擦学研究。自2015年11月加入中科院上海高等研究院,组建了“生物摩擦学实验室”,主要从事生物摩擦学及水基润滑领域功能界面材料研究。先后在摩擦学和表界面科学研究领域主流期刊发表论文50余篇,主持国家自然科学基金、上海市自然科学基金、European FP7 Marie Curie等项目6项,3M、Beiersdorf、Henkel、Johnson & Johnson等项目5项。
引用本文:
陈景民,李久盛,陈晋阳,曾祥琼. 模拟人体皮肤湿度响应特征和力学性质的皮肤模型[J]. 材料导报, 2019, 33(22): 3829-3832.
CHEN Jingmin, LI Jiusheng, CHEN Jinyang, ZENG Xiangqiong. A Skin Model Simulating Humidity Response Features and Mechanical Properties of Human Skin. Materials Reports, 2019, 33(22): 3829-3832.
渝公网安备50019002502923号 版权所有：《材料导报》编辑部
2019, Vol. 33 
