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材料导报  2021, Vol. 35 Issue (Z1): 322-327    
  金属与金属基复合材料 |
金纳米颗粒应用于肿瘤显像和治疗的研究进展
赵晨1,2, 毕常芬2, 郑宝鑫1,2, 侯文彬2, 李祎亮2
1 天津中医药大学中药学院,天津 301617
2 北京协和医学院 & 中国医学科学院放射医学研究所,天津市放射医学与分子核医学重点实验室,天津 300192
Research Progress on Application of Gold Nanoparticles in Tumor Imaging and Therapy
ZHAO Chen1,2, BI Changfen2, ZHENG Baoxin1,2, HOU Wenbin2, LI Yiliang2
1 College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2 Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin 300192, China
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摘要 金纳米颗粒(Gold nanoparticles, GNPs)具有许多优异的理化性质,这使其在肿瘤显像和治疗方面受到了越来越多的关注。例如:GNPs具有强的X射线衰减能力,可应用于电子计算机断层扫描(Computed tomography, CT)成像;GNPs可产生等离子体激元荧光(Plasmon enhanced fluorescence, PEF),增强荧光成像的效果;GNPs在激发光下会产生强电磁场,可用于表面增强拉曼散射;GNPs在近红外区域有较高的局域表面等离子共振(Localized surface plasmon resonance, LSPR)效应,可以应用于光声显像(Photoacoustic Imaging, PA)。GNPs具有放射增敏活性,在X射线辐射下,其表面可以产生二次辐射,从而提高放射治疗的效果;GNPs在近红外光区域表现出明显的光热效应,可将光能转化为热能,从而有效地消除肿瘤组织。此外,GNPs的表面很容易进行修饰,以用于递送药物、核酸、靶向肿瘤以及提高生物相容性。本文主要对GNPs在肿瘤显像以及治疗的研究进展进行综述。
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赵晨
毕常芬
郑宝鑫
侯文彬
李祎亮
关键词:  金纳米颗粒  肿瘤  显像  治疗    
Abstract: Gold nanoparticles (GNPs) has received great attention in the field of tumor imaging and therapy because of its excellent physical and chemical properties. GNPs provides high X-ray attenuation for Computed tomography (CT) imaging. After receiving the excitation light, plasmon enhanced fluorescence (PEF) can be produced by GNPs to enhance the effect of fluorescence imaging. GNPs can produce strong electromagnetic fields under excitation light, which can be used for surface enhanced Raman scattering. There is a high localized surface plasmon re-sonance (LSPR) effect of GNPs in the near infrared region, which can be applied for photoacoustic imaging (PA). GNPs are known to possess radiosensitizing activity,which can improve the effect of radiotherapy by producing the secondary radiation upon X-ray irradiation. Due to the broad absorption in the near-infrared range, GNPs shows a significant photothermal effect,it can convert light energy into heat energy, thus ablate tumor tissues effectively. In addition, the surface of GNPs can be easily modified to deliver drugs and nucleic acids, target tumors and improve biocompatibility. This article mainly reviews the research progress of GNPs in tumor imaging and therapy.
Key words:  gold nanoparticles    tumor    imaging    therapy
                    发布日期:  2021-07-16
ZTFLH:  R730.49  
  R730.59  
基金资助: 中国医学科学院医学与健康科技创新工程项目(2016-I2M-3-022);中央高校基本科研业务费专项资金(3332018117;3332020057);天津市科技计划(18ZXXYSY00110); 天津市自然科学基金(18JCQNJC09500)
通讯作者:  liyiliang@irm-cams.ac.cn;houwenbin@irm-cams.ac.cn   
作者简介:  赵晨,现为天津中医药大学中药学院硕士研究生。目前主要研究领域为纳米材料的制备与应用。李祎亮,博士,研究员,博士研究生导师。从事化学生物学和分子影像学基础研究工作;以及炎症、DNA损伤修复等分子靶标原创性创新药的发现等研究。侯文彬,博士,研究员。主要从事中药、天然药物创新药的发现、研究与开发。
引用本文:    
赵晨, 毕常芬, 郑宝鑫, 侯文彬, 李祎亮. 金纳米颗粒应用于肿瘤显像和治疗的研究进展[J]. 材料导报, 2021, 35(Z1): 322-327.
ZHAO Chen, BI Changfen, ZHENG Baoxin, HOU Wenbin, LI Yiliang. Research Progress on Application of Gold Nanoparticles in Tumor Imaging and Therapy. Materials Reports, 2021, 35(Z1): 322-327.
链接本文:  
http://www.mater-rep.com/CN/  或          http://www.mater-rep.com/CN/Y2021/V35/IZ1/322
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