三种金属有机框架对苯达莫司汀的载药研究

材料导报

2020, Vol. 34

Issue (Z1): 523-526

高分子与聚合物基复合材料

三种金属有机框架对苯达莫司汀的载药研究

赵僧群¹, 李旭蕊¹, 韩莎莎¹, 李丽^1,2

1 辽宁大学药学院,沈阳 110036;
2 辽宁省新药研发重点实验室,沈阳 110036

Study on Drug Loading of Bendamustine with Three Metal Organic Frameworks

ZHAO Sengqun¹, LI Xurui¹, HAN Shasha¹, LI Li^1,2

1 School of Pharmacy, Liaoning University, Shenyang 110036, China;
2 Liaoning Key Laboratory of New Drug Research & Development, Shenyang 110036, China

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摘要本研究以金属Zr离子为中心,分别与不同的有机配体合成了三种金属有机框架(MOFs)载体(UiO-66、UiO-66-NH₂、UiO-66-COOH),并采用浸渍法装载苯达莫司汀,考察了它们对苯达莫司汀的包载能力。通过红外光谱法、差示扫描量热法、热重分析法、X射线衍射法以及扫描电镜对载药前后的MOFs载体进行结构表征。结果表明:三种MOFs载体均成功载入苯达莫司汀,且三种MOFs载体载药前后晶型结构不发生改变,热稳定性较强,其中UiO-66-COOH的载药能力优于UiO-66-NH₂和UiO-66。因此,可以根据药物的具体官能团特性来合成匹配度高的相应MOFs载体,从而增加其载药量。

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关键词: 金属有机框架 UiO-66 UiO-66-NH₂ UiO-66-COOH 苯达莫司汀

Abstract: Three metal organic frameworks (MOFs), UiO-66, UiO-66-NH₂ and UiO-66-COOH, were synthesized with different organic ligands centered on metal Zr ions,then the bendamustine was loaded into them by impregnation method, and their loading capacities were investigated in this study. Infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction method and scanning electron microscope were used to characterize the MOFs before and after drug loading. The results showed that the three MOFs were successfully loaded with bendamustine and the crystal structures of them were not changed before and after drug loading. The thermal stability was strong and the drug-loading capacity of UiO-66-COOH was better than that of UiO-66-NH₂ and UiO-66. According to the specific functional group of the drug, the corresponding MOFs with high matching degree can be synthesized to increase the drug loading.

Key words: metal organic framework UiO-66 UiO-66-NH₂ UiO-66-COOH bendamustine

发布日期: 2020-07-01

ZTFLH:

R94

基金资助: 辽宁省自然科学基金(材料联合基金)(2018010051-301)

作者简介: 赵僧群,2017年6月毕业于沈阳药科大学,获得理学学士学位。现为辽宁大学药学院硕士研究生,在李丽副教授的指导下进行研究。目前主要研究领域为药物新剂型;李丽,辽宁大学药学院副教授,硕士研究生导师。2000年毕业于沈阳药科大学,获药物制剂工学学士学位,2005年毕业于沈阳药科大学,获药剂学硕士学位,2010年毕业于沈阳药科大学,获药剂学博士学位,2016年在美国密歇根大学安娜堡分校作为访问学者进修一年。2000—2002年工作于哈药集团制药六厂。长期从事药剂学的相关教学及科研工作,研究方向主要为纳米药物给药系统。工作期间共发表学术论文37篇。

引用本文:

赵僧群, 李旭蕊, 韩莎莎, 李丽. 三种金属有机框架对苯达莫司汀的载药研究[J]. 材料导报, 2020, 34(Z1): 523-526.
ZHAO Sengqun, LI Xurui, HAN Shasha, LI Li. Study on Drug Loading of Bendamustine with Three Metal Organic Frameworks. Materials Reports, 2020, 34(Z1): 523-526.

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http://www.mater-rep.com/CN/ 或 http://www.mater-rep.com/CN/Y2020/V34/IZ1/523

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