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材料导报  2023, Vol. 37 Issue (24): 22020189-5    https://doi.org/10.11896/cldb.22020189
  无机非金属及其复合材料 |
纳米羟基磷灰石对氯氧镁水泥降解性和体外生物活性的影响
李航, 廖建国*, 毛艳瑞, 阮文强
河南理工大学材料科学与工程学院,河南 焦作 454000
Effect of Nano-hydroxyapatite on Degradability and in Vitro Bioactivity of Magnesium Oxychloride Cement
LI Hang, LIAO Jianguo*, MAO Yanrui, RUAN Wenqiang
School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, Henan, China
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摘要 氯氧镁水泥(MOC)具有强度高、粘结性好和无细胞毒性等优点,可应用于骨修复材料领域。本工作将生物活性纳米羟基磷灰石(n-HAp)与MOC复合,研究了n-HAp掺量对MOC耐水性、降解性和生物活性的影响。结果显示n-HAp的最佳掺量为MgO质量的10%。在模拟体液(SBF)中浸泡28 d后,10% n-HAp-MOC的抗压强度((29.9±1.8) MPa)和软化系数(0.39)均高于未改性组MOC,质量损失率(34.5%)低于未改性组MOC,说明n-HAp的掺入增强了MOC的耐水性,从而有效地减缓了其降解速率。通过SBF的Ca2+、PO43-浓度变化和XRD图可知,MOC表面可沉积生成HAp晶体,即MOC具有生物活性,且n-HAp的掺入促进新生HAp晶体在MOC表面矿化沉积,增强了MOC的生物活性。
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李航
廖建国
毛艳瑞
阮文强
关键词:  骨水泥  氯氧镁水泥  纳米羟基磷灰石  耐水性  降解性  体外生物活性    
Abstract: Magnesium oxychloride cement(MOC) has the advantages of high strength, good adhesion and non-cytotoxicity, which can be applied in the field of bone repair materials. In this study, nano-hydroxyapatite (n-HAp), a bioactive material, was incorporated into MOC and the effects of n-HAp on water resistance, degradability and bioactivity of MOC were investigated. It was found that the best amount of n-HAp was 10% by mass of magnesium oxide. After soaking in simulated body fluid (SBF) for 28 d, the compressive strength ((29.9±1.8) MPa) and softening coefficient (0.39) of 10% n-HAp-MOC were higher than those of the unmodified MOC, and the mass loss rate (34.5%) was lower than that of the unmodified MOC. The addition of n-HAp enhanced the water resistance of MOC and thereby reduced effectively its degradation rate. Based on XRD analysis and ion concentration change, hydroxyapatite crystals could be deposited on the surface of MOC, indicating that MOC has biological activity. The incorporation of n-HAp promoted the growth of mineralized HAp crystals deposited on the surface of MOC and enhanced the bioactivity of MOC.
Key words:  bone cement    magnesium oxychloride cement    nano-hydroxyapatite    water resistance    degradability    in vitro bioactivity
发布日期:  2023-12-19
ZTFLH:  TB321  
基金资助: 河南省科技攻关项目(222102310112;222102320028);河南省教育厅基础研究计划 (19A430015;19B430004);河南省高校基本科研业务费专项资金(NSFRF180311)
通讯作者:  *廖建国,河南理工大学材料科学与工程学院副教授、硕士研究生导师,2008年毕业于四川大学生物医学工程专业,获工学博士学位,主要从事生物医学材料研究,在国内外期刊发表SCI/EI 收录论文20余篇,获国家发明专利6项。liaojianguo10@hpu.edu.cn   
作者简介:  李航,2019年6月毕业于河南理工大学,获得工学学士学位。现为河南理工大学材料科学与工程学院硕士研究生,在廖建国副教授的指导下进行研究。目前主要研究领域为生物材料。
引用本文:    
李航, 廖建国, 毛艳瑞, 阮文强. 纳米羟基磷灰石对氯氧镁水泥降解性和体外生物活性的影响[J]. 材料导报, 2023, 37(24): 22020189-5.
LI Hang, LIAO Jianguo, MAO Yanrui, RUAN Wenqiang. Effect of Nano-hydroxyapatite on Degradability and in Vitro Bioactivity of Magnesium Oxychloride Cement. Materials Reports, 2023, 37(24): 22020189-5.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.22020189  或          http://www.mater-rep.com/CN/Y2023/V37/I24/22020189
1 Yousefi A M. Journal of Applied Biomaterials & Functional Materials, 2019, 17(4), 2280800019872594.
2 Xu D, Song W, Zhang J, et al. Journal of Bioscience and Bioengineering, 2021, 132(2), 132.
3 Lodoso-Torrecilla I, van den Beucken J J J P, Jansen J A. Acta Biomaterialia, 2020, 119, 1.
4 Schröter L, Kaiser F, Stein S, et al. Acta Biomaterialia, 2020, 117, 1.
5 Tan Y, Liu Y, Grover L. Cement and Concrete Research, 2014, 56, 69.
6 Wen J, Liao J, Ying Q, et al. Journal of Materials Science, 2021, 56, 706.
7 Lowther M, Robinson T E, Villapun V M, et al. Materials Science and Engineering C, 2021, 126, 112158.
8 Zhang X, Ge S, Wang H, et al. Construction and Building Materials, 2017, 150, 409.
9 Li K, Wang Y, Yao N, et al. Construction and Building Materials, 2020, 255, 119381.
10 Ye Q, Wang W, Zhang W, et al. Journal of Hazardous Materials, 2020, 383, 121099.
11 Luo X, Fan W, Li C, et al. Construction and Building Materials, 2020, 246, 118428.
12 Gong W, Wang N, Zhang N, et al. Construction and Building Materials, 2020, 260, 119817.
13 Chen X, Zhang T, Bi W, et al. Construction and Building Materials, 2019, 213, 528.
14 Ye Q, Han Y, Liu T, et al. Construction and Building Materials, 2021, 280, 122487.
15 Guo Y, Zhang Y X, Soe K, et al. Journal of Cleaner Production, 2021, 313, 127682.
16 Tan Y, Liu Y, Zhao Z, et al. Journal of Biomedical Materials Research, 2015, 103(1), 194.
17 Mohd Pu’ad N A S, Koshy P, Abdullah H Z, et al. Heliyon, 2019, 5(5), e01588.
18 Sadat-Shojai M, Khorasani M, Dinpanah-Khoshdargi E, et al. Acta Biomaterialia, 2013, 9(8), 7591.
19 Miculescu F, Maidaniuc A, Voicu S I, et al. ACS Sustainable Chemistry & Engineering, 2017, 5(10), 8491.
20 Liu M, Huang C, Zhao Z, et al. Medicine in Novel Technology and Devices, 2019, 4, 100022.
21 Wang L, Pathak J L, Liang D, et al. International Journal of Biological Macromolecules, 2020, 142, 366.
22 Liao J, Li Y, Guan X, et al. Nano, 2016, 11(10), 1650115.
23 Kokubo T, Takadama H. Biomaterials, 2006, 27(15), 2907.
24 Li Y, Li Z, Pei H, et al. Construction and Building Materials, 2016, 102, 233.
25 Ye Q, Wang W, Zhang W, et al. Construction and Building Materials, 2018, 179, 413.
26 Huang J, Ge S, Wang H, et al. Construction and Building Materials, 2021, 306, 124872.
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