聚氨基酸材料的研究进展

doi:10.11896/cldb.21080287

材料导报

2022, Vol. 36

Issue (3): 21080287-18 https://doi.org/10.11896/cldb.21080287

生物医用材料

聚氨基酸材料的研究进展

杨方平¹, 宋子元¹, 殷黎晨¹, 唐浩宇¹, 程建军²

1 苏州大学功能纳米与软物质研究院,江苏苏州 215123
2 西湖大学工学院,杭州 310024

Research Progress of Synthetic Polypeptides Materials

YANG Fangping¹, SONG Ziyuan¹, YIN Lichen¹, TANG Haoyu¹, CHENG Jianjun²

1 Institute of Functional Nano and Soft Materials, Soochow University, Suzhou 215123, Jiangsu, China
2 School of Engineering, Westlake University, Hangzhou 310024, China

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摘要聚氨基酸是一类天然蛋白质模拟物,可以通过氨基酸-N-羧基环内酸酐开环聚合法制备。聚氨基酸凭借氨基酸结构多样性、独特的自组装结构和构象转变、高生物活性和良好的生物相容性,被广泛应用于生物材料领域。以自动加速、协同共价聚合为代表的开环聚合新方法为聚氨基酸材料的高效制备提供了保障。以α-螺旋、β-折叠聚氨基酸为基本结构单元的聚合物能自组装形成结构规整的纳米材料,为结构与功能仿生及生物应用奠定了基础。聚氨基酸能在酸碱度、光、热及氧化还原等条件下发生构象转变,材料二级结构的变化伴随着物理(如亲疏水性)、化学(如电荷翻转)和生物活性(如细胞毒性)等的改变,为材料适应生物微环境变化和靶向递送等提供了新思路。聚氨基酸材料在抗菌、防污、抗肿瘤、基因递送、组织工程和免疫调节等生物应用领域展示了良好的应用前景。本文重点综述了当前聚氨基酸材料在前沿制备方法、组装结构、构象转变和生物应用四个方面的研究进展,并对其未来发展需要解决的问题进行了展望,以期为聚氨基酸材料的深入研究提供参考。

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	杨方平
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	程建军

关键词: 聚氨基酸开环聚合自组装构象转变生物材料

Abstract: Synthetic polypeptides from the ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs) are a type of natural protein mimics. The unique features of these synthetic polypeptides, including the chemical diversity of amino acids, the unique self-assembly structures and conformation transition, and the desired biological activity and good biocompatibility, enable their broad biological applications. The new ROP method represented by auto-accelerated cooperative covalent polymerization provides a new direction for the efficient preparation of polypeptide materials. Additionally, polypeptides with α-helical or β-sheet conformations can be used as building blocks for self-assembly, forming unique chiral and nanomaterials, which benefit the research on structural and functional biomimetics and biomedical applications. The conformational transitions of polypeptide materials, triggered by pH, light, heat, redox, etc, are always accompanied by the changes in their physical pro-perties (such as hydrophobicity), chemical structures (such as charge reversion), and biological activity (such as cytotoxicity), offering a new strategy for materials to adapt to the changes of biological microenvironment and targeted delivery. As a result, polypeptide materials have shown great potentials in biological applications such as antibacterial, antifouling, antitumor, gene delivery, tissue engineering, and immune regulation. This review offers a retrospection of the research process of synthetic polypeptides materials, which covered advanced preparation methods, assembly structure, conformation transition, and biological applications. In order to provide reference for the further research of synthetic polypeptides, we also raised some important questions for this field.

Key words: polypeptides ring-opening polymerization self-assembly conformational transition biomaterials

发布日期: 2022-02-10

ZTFLH:	TB34
	O63

基金资助: 国家自然科学基金委面上项目(51873213)

通讯作者: hytang@suda.edu.cn;chengjianjun@westlake.edu.cn

作者简介: 杨方平,2018年毕业于山东师范大学化学院,获得理学学士学位。现为苏州大学功能纳米与软物质研究院博士研究生,在唐浩宇和程建军两位导师的联合指导下进行聚氨基酸材料制备与生物学性能研究的相关工作。
唐浩宇,苏州大学功能纳米与软物质研究院副研究员。2008年6月毕业于北京大学化学与分子工程学院,获得理学博士学位。2008年10月至2012年1月先后在美国路易斯安娜州立大学(LSU)和美国伊利诺伊大学厄巴纳-香槟分校(UIUC)从事博士后工作。2019年4月加盟苏州大学功能纳米与软物质研究院开展研究和教学工作。主要研究方向为高分子材料制备、表面改性、抗菌高分子等,以第一作者或通讯作者在Chem. Sci., Macromolecules, Biomacromolecules, Polym. Chem., Macromol. Rapid Commun.等SCI学术期刊发表研究论文70余篇。
程建军,西湖大学工学院院长,材料科学与工程讲席教授、博士研究生导师。于1993年在南开大学获得化学学士学位,于1996年在美国南伊利诺伊大学获得化学硕士学位,于2001年在加州大学圣巴巴拉分校获得材料科学博士学位。毕业后作为资深科学家在Insert Therapeutics工作至2004年,后在麻省理工学院从事博士后研究至2005年,同年就职于美国伊利诺伊大学厄巴纳-香槟分校(UIUC)材料科学与工程系任助理教授,2011年晋升为终身副教授,2015年晋升为该系终身正教授并获得伊利诺伊大学杰出晋升教授奖,2016年晋升为Hans Thurnauer讲席教授。2021年8月起,任西湖大学工学院院长和材料科学与工程讲席教授。程建军教授课题组共发表过文章200余篇, 拥有已获批40余项美国或国际专利。曾获美国国家自然科学基金会青年学者奖和美国国立卫生研究院院长创新奖。研究领域包括高分子化学、多肽、纳米材料和纳米药物、药物递送、癌症靶向技术。程建军教授是英国皇家化学会生物材料科学期刊的主编。他是美国国家发明家科学院院士、美国科学促进会会士、美国医学与生物工程学院会士、美国化学会高分子化学会士。

引用本文:

杨方平, 宋子元, 殷黎晨, 唐浩宇, 程建军. 聚氨基酸材料的研究进展[J]. 材料导报, 2022, 36(3): 21080287-18.
YANG Fangping, SONG Ziyuan, YIN Lichen, TANG Haoyu, CHENG Jianjun. Research Progress of Synthetic Polypeptides Materials. Materials Reports, 2022, 36(3): 21080287-18.

链接本文:

http://www.mater-rep.com/CN/10.11896/cldb.21080287 或 http://www.mater-rep.com/CN/Y2022/V36/I3/21080287

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