天然高分子多糖在药物传递领域中的应用

doi:10.11896/cldb.23050200

材料导报

2024, Vol. 38

Issue (19): 23050200-18 https://doi.org/10.11896/cldb.23050200

高分子与聚合物基复合材料

天然高分子多糖在药物传递领域中的应用

刘晨爽¹, 田野¹, 盛显良², 斯琴塔娜², 张玉辉^2,*

1 内蒙古农业大学材料科学与艺术设计学院,呼和浩特 010018
2 内蒙古农业大学理学院,呼和浩特 010018

Application of Natural Polysaccharides in Drug Delivery

LIU Chenshuang¹, TIAN Ye¹, SHENG Xianliang², XIN Siqintana², ZHANG Yuhui^2,*

1 College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, China
2 College of Science, Inner Mongolia Agricultural University, Hohhot 010018, China

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摘要天然高分子多糖因具有良好的生物相容性、可降解性、易修饰性和无毒等特点而成为制备超分子纳米药物载体的极佳选择之一。在载体构筑过程中,二硫键、硼酸酯键和碳氮键等动态共价键的引入不仅提高了药物的负载量,还增强了纳米载体的生物相容性,并为载体提供了刺激响应位点,使其在药物传递过程中可以通过pH、光和酶等刺激实现药物的靶向释放,使药物传递体系更加智能、便捷和可控。本文从天然高分子多糖类型、动态共价键类型、刺激响应类型以及天然高分子多糖载体的临床适应症类型这四个方面综述了天然高分子多糖在药物传递领域中的应用,并对其当前面临的主要挑战和未来的发展趋势进行了总结和展望。

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	刘晨爽
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关键词: 天然高分子多糖药物载体动态共价键刺激响应

Abstract: Natural polysaccharides are ideal materials for the preparation of nano-drug carrier systems because of their intrinsic characteristics: good biocompatibility, biodegradability, ease of modification and low toxicity. The incorporation of dynamic covalent bonds such as disulfide bonds, boronate bonds, C-N bonds are a versatile tool for the construction of drug carriers, which can increase drug loading, enhance the biocompatibility, and provide the stimulus-responsive sites. In this regard, many stimuli, such as pH, light and enzyme could be exploited as triggers for drug release, thus making the drug delivery system more intelligent, convenient and controllable. In this paper, the applications of natural polysaccharides in drug delivery systems are reviewed from four aspects: the natural polysaccharides types, dynamic covalent bonds types, stimulus-response types and the clinical indication types of natural polysaccharides. The main challenges and future advances in this field are also detailed.

Key words: natural polysaccharides drug carrier dynamic covalent bonds stimulus-responsive

出版日期: 2024-10-10 发布日期: 2024-10-23

ZTFLH:

O636

基金资助: 国家自然科学基金(52263013);内蒙古自治区自然科学基金(2021MS02023);内蒙古农业大学青年教师科研能力提升专项(BR220140);内蒙古自治区草原英才人才工程项目(DC2000000745);内蒙古农业大学高层才人才启动项目(NDGCC2016-21)

通讯作者: ^*张玉辉,通信作者,内蒙古农业大学理学院副教授、博士研究生导师。2011—2016年在南开大学攻读博士学位,师从刘育教授,2016年进入内蒙古农业大学工作。主要从事刺激响应性药物载体的构筑及应用研究,发表SCI论文10余篇,授权发明专利5项,出版专著和教材4部,包括Chemical Communications、Chinese Chemical Letters、Organic Chemistry Frontiers等。yh_zhangyh@126.com

作者简介: 刘晨爽,2019年6月毕业于北京交通大学海滨学院获得工学学士学位。现为内蒙古农业大学材料科学与艺术设计学院硕士研究生,在盛显良教授和张玉辉副教授的指导下进行研究。目前主要从事刺激响应性多糖药物载体的构筑及性能研究。

引用本文:

刘晨爽, 田野, 盛显良, 斯琴塔娜, 张玉辉. 天然高分子多糖在药物传递领域中的应用[J]. 材料导报, 2024, 38(19): 23050200-18.
LIU Chenshuang, TIAN Ye, SHENG Xianliang, XIN Siqintana, ZHANG Yuhui. Application of Natural Polysaccharides in Drug Delivery. Materials Reports, 2024, 38(19): 23050200-18.

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http://www.mater-rep.com/CN/10.11896/cldb.23050200 或 http://www.mater-rep.com/CN/Y2024/V38/I19/23050200

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