血小板囊泡作为药物递送载体的研究综述

doi:10.11896/cldb.21010078

材料导报

2022, Vol. 36

Issue (19): 21010078-8 https://doi.org/10.11896/cldb.21010078

高分子与聚合物基复合材料

血小板囊泡作为药物递送载体的研究综述

刘欢, 秦凌浩

广东药科大学药学院,广州 510006

On the Use of Platelet Derived Vesicles as Drug Delivery Carrier: a Review

LIU Huan, QIN Linghao

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China

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摘要传统纳米载体系统虽然可以改善药物在体内的分布特征及细胞摄取行为,但无法避免网状内皮系统截留引起的被动靶向及体循环时间短的难题。随着生物工程技术的不断发展,越来越多的研究指出采用细胞囊泡仿生纳米载体可有效克服传统纳米载体的天然缺陷。血小板由骨髓巨核细胞产生,是血液中最小的血细胞,参与体内止血、伤口愈合、血栓形成等生理过程,同样在炎症、免疫和肿瘤转移中发挥重要作用。利用血小板囊泡的生理特性构建药物递送载体能够保留胞膜表面的特异性蛋白,借以实现药物体内长循环、主动靶向及免疫逃逸效果。目前血小板囊泡已成功用于负载小分子药物、无机化合物、核酸药物、载药纳米粒等以用于心血管疾病、肿瘤、抗感染的治疗。基于目前针对血小板囊泡药物载体的持续关注及深入研究,本文对此进行了评述及展望。

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	刘欢
	秦凌浩

关键词: 血小板囊泡药物载体疾病治疗疾病诊断

Abstract: Although conventional nanocarrier systems can improve the in-vivo drug biodistribution characteristics and cellular uptake behavior, challenges of passive targeting in liver tissue and short systemic circulation time caused by reticuloendothelial system entrapment cannot be ignored. With the continuous development of bioengineering technology, more and more evidence has revealed that application of biomimetic nanocarriers derived from cell vesicles can overcome the defects of synthesized drug nanocarriers. Platelets produced by megakaryocytes in bone marrow are the smallest cells in blood, which participate in numerous physiological processes involving hemostasis, wound healing and thrombosis formation, and also play the important roles in inflammation, immune regulation and tumor metastasis. By utilizing the unique functions of cell membrane proteins, platelet vesicle carriers can effectively transport drugs to achieve long time circulation, active targeting and immune system escaping effects. Till now, numerous drug nanocarrier systems based on platelet derived vesicles have been successfully developed to transport various kinds of cargos including small molecule drugs, inorganic compounds, nucleic acid and nanoparticles for the treatment of cardiovascular diseases, malignant tumors and infectious diseases. Given the continued focus and intensive studies on platelet vesicle drug carriers, this paper gives a comprehensive review of the latest researches as well as the perspective discussion on challenges and development trends.

Key words: platelet derived vesicles drug carrier disease treatment disease diagnosis

出版日期: 2022-10-10 发布日期: 2022-10-12

ZTFLH:

TB39

基金资助: 广东省教育厅重点科研平台及项目(2022ZDZX2034);广州市科技计划项目(201604046022; 201802030002);广东省自然科学基金(2014A030310362)

通讯作者: qins_lab@163.com

作者简介: 刘欢,2019年7月毕业于赣南医学院,获得制药工程学士学位,2022年7月毕业于广东药科大学药学院,获得硕士学位,研究方向为仿生给药系统。
秦凌浩,广东药科大学副教授、硕士研究生导师。1999—2006年就读于沈阳药科大学,获得学士学位和硕士学位,2014年于南方医科大学获得博士学位。主要从事药用高分子材料、新型给药系统及工业药剂学的研究,发表文章40余篇。

引用本文:

刘欢, 秦凌浩. 血小板囊泡作为药物递送载体的研究综述[J]. 材料导报, 2022, 36(19): 21010078-8.
LIU Huan, QIN Linghao. On the Use of Platelet Derived Vesicles as Drug Delivery Carrier: a Review. Materials Reports, 2022, 36(19): 21010078-8.

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http://www.mater-rep.com/CN/10.11896/cldb.21010078 或 http://www.mater-rep.com/CN/Y2022/V36/I19/21010078

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