Please wait a minute...
材料导报  2022, Vol. 36 Issue (3): 21120202-15    https://doi.org/10.11896/cldb.21120202
  生物医用材料 |
智能响应型小分子探针在肿瘤诊疗方面的研究进展
叶舒岳, 冯雅丽, 史海斌
苏州大学苏州医学院,放射医学与防护学院,放射医学与辐射防护国家重点实验室,江苏 苏州 215123
Recent Advances in Smart Molecular Probes for Tumor Theranostics
YE Shuyue, FENG Yali, SHI Haibin
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Suzhou Medical College, Soochow University, Suzhou 215123, Jiangsu, China
下载:  全 文 ( PDF ) ( 20266KB ) 
输出:  BibTeX | EndNote (RIS)      
摘要 自从美国耶鲁大学科学家古德曼和吉尔曼偶然发现化合物氮芥能够使患有淋巴癌的小鼠肿块变小,从此开启了癌症药物治疗的新篇章。目前虽然已有大量药物被研发出来并成功用于临床肿瘤的诊断与治疗,但它们仍然存在如生物相容性不好、毒副作用大和耐药性等问题。因此,开发新型、高效的肿瘤诊疗药物迫在眉睫。近年来,研发智能化响应型肿瘤探针逐渐引起科学家们的兴趣。以肿瘤微环境特征因素(微酸、酶、氧化-还原物质、乏氧和信号分子等)和外源场(光、射线和超声等)等为刺激体,一大批刺激响应型肿瘤探针被设计和制备。研究结果表明这些探针不仅提高了肿瘤的诊疗效果还显著降低了对机体的毒副作用,有望实现肿瘤的精准诊治。本文着重介绍了肿瘤诊疗分子探针的发展历程,总结了近两年来智能响应型小分子探针在肿瘤诊疗方面的应用进展,展望了智能化响应型探针在肿瘤诊疗领域的发展方向和愿景。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
叶舒岳
冯雅丽
史海斌
关键词:  智能探针  刺激响应材料  肿瘤成像  肿瘤治疗  诊疗一体化    
Abstract: Since scientist Goodman and Gilmanat Yale University accidentally discovered that compound nitrogen mustard can suppress lymphoma in mice bearing lymphatic cancer, a new chapter in chemotherapy of cancers has been opened. To date, many drugs have been explored and successfully used for the diagnosis and treatment of tumors in clinics, but most of them encounter the problems such as poor biocompatibility, large side effect, and drug resistance. Therefore, it is urgent to develop novel theranostic drugs for effective cancer diagnosis and treatment. Recently, developing smart probes for tumor theranostics has gradually aroused great interest of scientists. Currently, a large number of stimuli-responsive probes for tumor imaging and treatment were designed and prepared choosing certain tumor microenvironment factors (acidic, environment, enzymes, redox special, hypoxia and signal molecule, etc) and exogenous fields (light, radiation and ultrasound, etc). Many researches have demonstrated these probes not only improve the theranostic efficacy, but also significantly reduce the toxic and side effect to the body, realizing the precise diagnosis and treatment of tumors. We mainly introduce the development of molecular probes for tumor theranostics in this paper, and summarize the application advances of smart probes in tumor theranostic in the past two years. Finally, a prospective for the future development direction and vision of stimulus-responsive probes in the field of cancer theranostics was also given.
Key words:  smart probe    stimuli-responsive materials    tumor imaging    tumor therapy    theranostics
发布日期:  2022-02-10
ZTFLH:  R445.9  
基金资助: 国家自然科学基金委重大研究计划培育项目(91959123);国家自然科学基金委面上项目(22077092);江苏省重点研发计划(社发)项目(BE2018655)
通讯作者:  hbshi@suda.edu.cn   
作者简介:  叶舒岳,2021年6月毕业于苏州大学,获得医学博士学位。现为德克萨斯大学西南医学中心博士后研究员,先前在史海斌教授的指导下进行研究。主要研究领域为分子影像。截止目前,在J. Am. Chem. Soc., Adv. Mater., Angew. Chem. Int. Ed., Anal. Chem., Nanoscale等学术期刊上共发表学术论文多篇。
史海斌,苏州大学放射医学与辐射防护国家重点实验室教授、苏州大学影像医学研究所副所长,国家级青年人才计划项目获得者、国家重点研发计划青年项目首席科学家和江苏省双创人才等。2006年于苏州大学获硕士学位,2012年于新加坡国立大学获博士学位,2012至2014年在美国斯坦福大学医学院分子影像中心从事博士后研究。2014年入职苏州大学,研究方向主要致力于分子探针的设计构建及生物成像研究。在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater.等期刊上发表论文50余篇。
引用本文:    
叶舒岳, 冯雅丽, 史海斌. 智能响应型小分子探针在肿瘤诊疗方面的研究进展[J]. 材料导报, 2022, 36(3): 21120202-15.
YE Shuyue, FENG Yali, SHI Haibin. Recent Advances in Smart Molecular Probes for Tumor Theranostics. Materials Reports, 2022, 36(3): 21120202-15.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.21120202  或          http://www.mater-rep.com/CN/Y2022/V36/I3/21120202
1 Sung H, Ferlay J, Siegel R L, et al. A Cancer Journal for Clinicians, 2021, 71(3), 209.
2 Zhao N, Yan L, Zhao X, et al. Chemical Reviews, 2019, 119(3), 1666.
3 Kelkar S S, Reineke T M. Bioconjugate Chemistry, 2011, 22(10), 1879.
4 Algar W R, Massey M, Rees K, et al. Chemical Reviews, 2021, 121(15), 9243.
5 Yang M, Fan J, Du J, et al. Chemical Science, 2020, 11(20), 5127.
6 Zhao Z, Zhang H, Lam J W Y, et al. Angewandte Chemie International Editions, 2020, 59(25), 9888.
7 Hanahan D, Weinberg R A. Cell, 2011, 144(5), 646.
8 Hu L, Wan Y, Zhang Q, et al. Advanced Functional Materials, 2019, 30(2), 1903471.
9 Karimi M, Ghasemi A, Sahandi Zangabad P, et al. Chemical Society Reviews, 2016, 45(5), 1457.
10 Bhuniya S, Maiti S, Kim E J, et al. Angewandte Chemie International Editions, 2014, 53(17), 4469.
11 Souho T, Lamboni L, Xiao L, et al. Biotechnology Advances, 2018, 36(7), 1928.
12 McCune J A, Mommer S, Parkins C C, et al. Advanced Materials, 2020, 32(20), e1906890.
13 Lin H, Chen Y, Shi J. Coordination Chemistry Reviews, 2018, 47(6), 1938.
14 Lin F C, Xie Y, Deng T, et al. Journal of the American Chemical Society, 2021, 143(16), 6025.
15 Birhan Y S, Tsai H C. Journal of Materials Chemistry B, 2021, 9(34), 6770.
16 Li J, Pu K. Chemical Sociaty Review, 2019, 48(1), 38.
17 Ovais M, Mukherjee S, Pramanik A, et al. Advanced Materials, 2020, 32(22), e2000055.
18 Hai Z, Liang G. Advanced Biosystems, 2018, 2(8).
19 Wang X, Wang X, Jin S, et al. Chemical Reviews, 2019, 119(2), 1138.
20 Muhammad K, Zhao J, Gao B, et al. Journal of Materials Chemistry B, 2020, 8(42), 9621.
21 Kim S Y, Podder A, Lee H, et al. Chemical Science, 2020, 11(36), 9875.
22 Wang A, Mao Q, Zhao M, et al. Analytical Chemistry, 2020, 92(24), 16113.
23 Liu X, Gong X, Yuan J, et al. Analytical Chemistry, 2021, 93(13), 5420.
24 Yang J, An H W, Wang H. ACS Applied Bio Materials, 2020, 4(1), 24.
25 Liu H W, Chen L, Xu C, et al. Coordination Chemistry Reviews, 2018, 47(18), 7140.
26 Yin L, Sun H, Zhang H, et al. Journal of the American Chemical Society, 2019, 141(7), 3265.
27 Yuan Y, Zhang J, Qi X, et al. Nature Materials, 2019, 18(12), 1376.
28 Guo R C, Zhang X H, Fan P S, et al. Angewandte Chemie International Editions, 2021, 60(47), 25128.
29 Li H, Yao Q, Sun W, et al. Journal of the American Chemical Society, 2020, 142(13), 6381.
30 Yang B, Chen Y, Shi J. Chemical Reviews, 2019, 119(8), 4881.
31 Gao Y, Sun R, Zhao M, et al. Analytical Chemistry, 2020, 92(10), 6977.
32 An R, Cheng X, Wei S, et al. Angewandte Chemie International Editions, 2020, 59(46), 20636.
33 Wang B, Zhao Q, Zhang Y, et al. Journal of Experimental & Clinical Cancer Research, 2021, 40(1), 24.
34 Sun Y, Zhao D, Wang G, et al. Acta Pharmaceutica Sinica B, 2020, 10(8), 1382.
35 Zhang Y, Zhao W, Chen Y, et al. Nature Communications, 2021, 12(1), 2772.
36 Li M, Li H, Wu Q, et al. iScience, 2021, 24(3), 102261.
37 Szabo C, Coletta C, Chao C, et al. Proceedings of the National Academy of Sciences (USA), 2013, 110(30), 12474.
38 Chen X, Wang F, Hyun J Y, et al. Chemical Society Reviews, 2016, 45(10), 2976.
39 Strianese M, Pellecchia C. Coordination Chemistry Reviews, 2016, 318, 16.
40 Dang Y, Ruan L, Tian Y, et al. Analytical Chemistry, 2021, 93(21), 7625.
41 Wang R, Gu X, Li Q, et al. Journal of the American Chemical Society, 2020, 142(35), 15084.
42 Geng J, Zhang Y, Gao Q, et al. Nature Chemistry, 2021, 13(8), 805.
43 Fu Q, Li H, Duan D, et al. Angewandte Chemie International Editions, 2020, 59(48), 21546.
44 Weinstain R, Slanina T, Kand D, et al. Chemical Reviews, 2020, 120(24), 13135.
45 Lim K S, Galarraga J H, Cui X, et al. Chemical Reviews, 2020, 120(19), 10662.
46 Ye S, Cui C, Cheng X, et al. Journal of the American Chemical Society, 2020, 142(51), 21502.
47 Huang L, Zeng L, Chen Y, et al. Nature Communications, 2021, 12(1), 122.
48 Son S, Kim J H, Wang X, et al. Chemical Society Reviews, 2020, 49(11), 3244.
49 Du J, Zhang Y, Ge H, et al. Chemical Communications, 2020, 56(54), 7503.
50 Huo S, Zhao P, Shi Z, et al. Nature Chemistry, 2021, 13(2), 131.
51 Cheng D B, Zhang X H, Chen Y, et al. iScience, 2020, 23(6), 101144.
[1] 张雪雁, 孟昭旭, 廉鹤. 普鲁士蓝基纳米粒子在癌症治疗及成像中的应用进展[J]. 材料导报, 2020, 34(Z2): 95-98.
[2] 王怀基, 董海青. 还原响应的白蛋白纳米颗粒负载甲氨蝶呤用于抗肿瘤治疗[J]. 材料导报, 2019, 33(Z2): 547-552.
[3] 杨焜, 王春来, 丁晟, 刘长军, 田丰, 李钒. 荧光碳量子点:合成、特性及在肿瘤治疗中的应用[J]. 材料导报, 2019, 33(9): 1475-1482.
[1] Wei ZHOU, Xixi WANG, Yinlong ZHU, Jie DAI, Yanping ZHU, Zongping SHAO. A Complete Review of Cobalt-based Electrocatalysts Applying to Metal-Air Batteries and Intermediate-Low Temperature Solid Oxide Fuel Cells[J]. Materials Reports, 2018, 32(3): 337 -356 .
[2] Dongyong SI, Guangxu HUANG, Chuanxiang ZHANG, Baolin XING, Zehua CHEN, Liwei CHEN, Haoran ZHANG. Preparation and Electrochemical Performance of Humic Acid-based Graphitized Materials[J]. Materials Reports, 2018, 32(3): 368 -372 .
[3] Yunzi LIU,Wei ZHANG,Zhanyong SONG. Technological Advances in Preparation and Posterior Treatment of Metal Nanoparticles-based Conductive Inks[J]. Materials Reports, 2018, 32(3): 391 -397 .
[4] Bingwei LUO,Dabo LIU,Fei LUO,Ye TIAN,Dongsheng CHEN,Haitao ZHOU. Research on the Two Typical Infrared Detection Materials Serving at Low Temperatures: a Review[J]. Materials Reports, 2018, 32(3): 398 -404 .
[5] Yingke WU,Jianzhong MA,Yan BAO. Advances in Interfacial Interaction Within Polymer Matrix Nanocomposites[J]. Materials Reports, 2018, 32(3): 434 -442 .
[6] Zhengrong FU,Xiuchang WANG,Qinglin JIN,Jun TAN. A Review of the Preparation Techniques for Porous Amorphous Alloys and Their Composites[J]. Materials Reports, 2018, 32(3): 473 -482 .
[7] Fangyuan DONG,Shansuo ZHENG,Mingchen SONG,Yixin ZHANG,Jie ZHENG,Qing QIN. Research Progress of High Performance ConcreteⅡ: Durability and Life Prediction Model[J]. Materials Reports, 2018, 32(3): 496 -502 .
[8] Lixiong GAO,Ruqian DING,Yan YAO,Hui RONG,Hailiang WANG,Lei ZHANG. Microbial-induced Corrosion of Concrete: Mechanism, Influencing Factors,Evaluation Indices, and Proventive Techniques[J]. Materials Reports, 2018, 32(3): 503 -509 .
[9] Ningning HE,Chenxi HOU,Xiaoyan SHU,Dengsheng MA,Xirui LU. Application of SHS Technique for the High-level Radioactive Waste Disposal[J]. Materials Reports, 2018, 32(3): 510 -514 .
[10] Haoran CHEN, Yingdong XIA, Yonghua CHEN, Wei HUANG. Low-dimensional Perovskites: a Novel Candidate Light-harvesting Material for Solar Cells that Combines High Efficiency and Stability[J]. Materials Reports, 2018, 32(1): 1 -11 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed