有机室温磷光材料在生物医学中的应用

doi:10.11896/cldb.22010004

材料导报

2022, Vol. 36

Issue (3): 22010004-11 https://doi.org/10.11896/cldb.22010004

生物医用材料

有机室温磷光材料在生物医学中的应用

丁梅鹃, 史慧芳, 安众福

南京工业大学先进材料研究院,南京 211816

Organic Room Temperature Phosphorescent Materials for Biomedical Applications

DING Meijuan, SHI Huifang, AN Zhongfu

Institution of Advanced Materials, Nanjing Tech University (Nanjing Tech), Nanjing 211816, China

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摘要近年来,纯有机室温磷光(RTP)材料由于具有长的激发态寿命、大的Stokes位移、丰富的激发态性质等特点而备受研究者的广泛关注。相较于重金属配合物或无机磷光材料,有机磷光材料的原料来源广、成本低、合成条件温和,兼具质轻、柔性、可大面积制备等诸多优势,室温磷光材料在数据加密、传感、有机电致发光、生物成像等领域展现出良好的应用前景。
有机磷光材料具有长寿命发光和三线态发射的特征,利用时间分辨技术能有效扣除生物组织自身的背景荧光干扰,极大地提高生物传感和成像的灵敏度与信噪比,并通过与三线态氧气的TTA过程,有望实现这类材料在光动力抗癌与抗菌等生物领域的应用。而且纯有机磷光材料不存在重金属元素的毒性问题。因此,纯有机磷光材料在生物成像、癌症治疗等生物领域实现很好的应用。本文总结了近年来有机室温磷光在生物应用中的研究进展,包括生物成像、生物传感、光动力抗癌、抗菌等。最后,提出该领域尚待解决的问题并展望未来前景。

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关键词: 有机室温磷光纳米材料生物成像

Abstract: In recent years, pure organic room temperature phosphorescent (RTP) materials have received extensive attention from researchers due to their long-excited state lifetime, large Stokes shift, and rich excited state properties. Compared with heavy metal complexes or inorganic phosphorescent materials, organic phosphorescent materials have a wide range of raw materials, low cost, mild synthesis conditions, light weight, flexibility, large area preparation, and many other advantages. Thus, RTP materials show great potential in the field of data encryption, sensing, organic electroluminescence, biological imaging and others.
Organic phosphorescent materials have the characteristics of long-lived luminescence and triplet emission. The use of time-resolved technology can effectively eliminate the background fluorescence interference of biological tissues, which greatly improves the sensitivity and signal-to-noise ratio of biosensing and imaging. And through the TTA process with triplet oxygen, it is expected to realize the application of such materials in biological fields such as photodynamic anticancer and antibacterial. Moreover, pure organic phosphorescent materials do not have the toxicity from heavy metals. Therefore, pure organic phosphorescent materials have achieved good applications in biological fields such as biological imaging and cancer treatment. In this review, we summarized the research progress of organic room temperature phosphorescence in biological applications, including bioimaging, biosensing, photodynamic anticancer, antibacterial, etc. Finally, we propose the problems and outlook in this field.

Key words: organic room temperature phosphorescence nanomaterials bioimaging

发布日期: 2022-02-10

ZTFLH:

O621.2

基金资助: 国家自然科学基金(21975120;21875104)

通讯作者: iamhfshi@njtech.edu.cn

作者简介: 丁梅鹃,2018年6月毕业于巢湖学院,获得工学学士学位。现为南京工业大学先进材料研究院博士研究生,在安众福教授的指导下进行研究。目前主要研究领域为室温有机磷光材料。
史慧芳,南京工业大学先进材料研究院教授。2008年毕业于青岛科技大学,获理学、文学双学士学位;2008—2013年在南京邮电大学与新加坡国立大学联合培养,获工学博士学位;同年赴新加坡南洋理工大学从事博士后研究。2015年7月加入南京工业大学先进材料研究院,从事有机光电功能材料的研究。研究成果先后以第一作者或通讯作者身份发表在Nature Photonics、Nature Communications、Angewandte Chemie International Edition等国际顶级学术期刊上。目前,已发表SCI论文60余篇,其中第一作者(含共同第一作者)与通讯作者论文32篇。申请中国发明专利8项,授权3项。主持国家自然科学基金青年项目、面上项目等。
安众福,南京工业大学先进材料研究院教授、博士研究生导师。2014年获得南京邮电大学博士学位; 2014年5月赴新加坡国立大学化学系从事博士后研究;2015年加入南京工业大学先进材料研究院,主要研究方向是有机光电材料与器件。截至目前,以第一作者或通讯作者身份在Nature Materials、Nature Photonics、Nature Communications等顶级学术期刊上共发表SCI收录论文80余篇。多次受邀参加国内外学术会议。公开或授权发明专利9项。主持国家自然科学基金面上项目、江苏省自然科学基金杰出青年基金等,入选江苏省“六大人才高峰”高层次人才计划与江苏省“333高层次人才培养工程”培养对象。获教育部高等学校科学研究优秀成果奖自然科学奖一等奖、首届京博科技进步奖、江苏省优秀博士学位论文等。

引用本文:

丁梅鹃, 史慧芳, 安众福. 有机室温磷光材料在生物医学中的应用[J]. 材料导报, 2022, 36(3): 22010004-11.
DING Meijuan, SHI Huifang, AN Zhongfu. Organic Room Temperature Phosphorescent Materials for Biomedical Applications. Materials Reports, 2022, 36(3): 22010004-11.

链接本文:

http://www.mater-rep.com/CN/10.11896/cldb.22010004 或 http://www.mater-rep.com/CN/Y2022/V36/I3/22010004

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