Research Progress of Ferrous Ion Fluorescent Probe
LI Jiajia1, ZHANG Ruilong1,*, ZHANG Zhongping2
1 School of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, China 2 Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, China
Abstract: Ferrous ion (Fe2+), as the most abundant iron element in living organisms, is closely related to the metabolism in live organisms. The abnormal Fe2+ levels involve in the occurrence and development of various diseases such as anemia, cancer and cardiovascular diseases. Therefore, the monitoring of Fe2+ fluctuation in living systems is of great significance to evaluate human health. Among of the several Fe2+ detection approaches, fluorescence method is widely employed due to its easy operation and on-site capability in vivo/in vitro. Design and screening of fluorescent probes play key roles in fluorescence detection. However, a typical difficulty of the traditional fluorescent probes is how to avoid the interference from other metal ions (such as calcium, magnesium and potassium). Thus, the designs of fluorescent probes with excellent specificity, photostability, sensitivity and biocompatibility have been devoted by scientists. According the materials of probes, they are always classified into organic molecular probes and nano probes. In parallel, the probes included three reaction mechanisms for detecting Fe2+: (1) reduction of NO groups;(2) chelation with Fe2+;(3) specifical reaction with Fe2+ (for example: Fenton reaction, selective cleavage of amide or hydroxylamine bonds, etc.). Here, we have summarized the research progress of Fe2+ fluorescent probes in the past decade, including synthesis methods, detection mechanism and bio-application progress. We envision the further optimization of the luminescence property, detection limit and specificity of fluorescent probe.
通讯作者:
*张瑞龙,安徽大学化学化工学院副教授、硕士研究生导师。2016年毕业于中国科学技术大学,取得博士学位。研究方向为荧光探针与细胞成像——通过多响应型单分子荧光探针研究细胞内不同生物分子之间的相互关联性。曾在Journal of the American Chemical Society、Angewandte Chemie International Edition、Analytical Chemistry 等杂志发表多篇学术论文。目前主持国家自然科学基金面上和青年项目各一项。
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