介孔二氧化硅门控开关在分析检测中的研究进展

doi:10.11896/cldb.20050051

材料导报

2021, Vol. 35

Issue (15): 15081-15087 https://doi.org/10.11896/cldb.20050051

无机非金属及其复合材料

介孔二氧化硅门控开关在分析检测中的研究进展

张䶮^1,2, 朱永乐², 黄丽娟², 王永安², 赵瑾³, 聂志勇²

1 天津大学化工学院,天津 300350
2 军事医学研究院毒物药物研究所,抗毒药物与毒理学国家重点实验室,北京 100850
3 军事医学研究院科研计划处,北京 100850

Advances of Mesoporous Silica Gated Switches in Analysis and Detection

ZHANG Yan^1,2, ZHU Yongle², HUANG Lijuan², WANG Yongan², ZHAO Jin³, NIE Zhiyong²

1 School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
2 State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
3 Division of Research Programs and Planning, Academy of Military Medical Sciences, Beijing 100850, China

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摘要介孔二氧化硅纳米粒子由于具有独特的结构特征和物理化学性质,可作为包载光及化学活性物质的优良载体;小分子化合物、核酸、抗体、蛋白质等功能分子通过修饰介孔二氧化硅纳米粒子以实现对包载物的封堵及对目标物的靶向作用;基于介孔二氧化硅纳米粒子及功能分子构建的智能纳米门控开关已被用于与疾病相关的生物标志物、化学战剂、爆炸品、毒品等小分子化合物的分析和检测,并逐步应用于高灵敏度化学传感器的构建。本文结合介孔二氧化硅纳米粒子功能化设计及存在的科学问题,就其在荧光探针和化学传感器构建中的应用及最新研究进展进行了综述,并对其未来发展方向进行了展望。

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关键词: 介孔二氧化硅纳米门控开关荧光探针化学传感器功能分子

Abstract: Mesoporous silica nanoparticles can be used as excellent carriers for photoactive and chemically active substances due to their unique structural characteristics and physicochemical properties. The blocking action to the inclusions and targeting effect to analytes could be realized when mesoporous silica nanoparticles were modified and functionalized by small molecule compounds, nucleic acids, antibodies, proteins and other functional molecules. Intelligent nano-gated switches based on mesoporous silica nanoparticles and functional molecules have been used for the analysis and detection of small molecular compounds such as disease-related biomarkers, chemical warfare agents, explosives, drugs. In addition, intelligent nano-gated switches have been gradually applied to the construction of highly sensitive chemical sensors. In this paper, combined with the functionalization design of mesoporous silica nanoparticles and the existing scientific problems in application, the recent advances of mesoporous silica nanoparticles in the construction of fluorescent probes and chemical sensors are reviewed, and the future development direction is prospected.

Key words: mesoporous silica nano-gated switches fluorescent probes chemical sensors functional molecules

出版日期: 2021-08-10 发布日期: 2021-08-31

ZTFLH:	O613.72
	TB381
	O65
	TP212

基金资助: 军内科研项目

作者简介: 张龑,2018年6月毕业于沈阳药科大学,获得工学学士学位。现为天津大学-军事医学研究院联合培养硕士研究生,在聂志勇副研究员的指导下进行研究。目前主要研究方向为药物分析。
赵瑾,副研究员,2006年获军事医学科学院军事预防医学专业博士学位。长期从事军事药学相关研究与管理工作,先后发表学术论文20余篇。
聂志勇,副研究员,2011年获药物分析学博士学位。主要从事毒剂毒物检测鉴定、吸入毒理分析及中毒对抗措施研究,近年在Food Chemi-stry、Talanta、《中国科学》等国内外期刊发表论文30余篇,参与专著及教材编写6部,获科技奖2项,因抗震救灾、应急救援等荣立个人三等功共3次。

引用本文:

张䶮, 朱永乐, 黄丽娟, 王永安, 赵瑾, 聂志勇. 介孔二氧化硅门控开关在分析检测中的研究进展[J]. 材料导报, 2021, 35(15): 15081-15087.
ZHANG Yan, ZHU Yongle, HUANG Lijuan, WANG Yongan, ZHAO Jin, NIE Zhiyong. Advances of Mesoporous Silica Gated Switches in Analysis and Detection. Materials Reports, 2021, 35(15): 15081-15087.

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http://www.mater-rep.com/CN/10.11896/cldb.20050051 或 http://www.mater-rep.com/CN/Y2021/V35/I15/15081

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