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材料导报  2022, Vol. 36 Issue (13): 20090055-14    https://doi.org/10.11896/cldb.20090055
  无机非金属及其复合材料 |
具有类过氧化物酶活性的纳米材料在比色分析中的研究进展
陈达, 刘美含, 张伟, 练美玲*
中国民航大学民航热灾害防控与应急重点实验室,天津 300300
Progress in Colorimetric Analysis of Nanomaterials with Peroxidase-like Activity
CHEN Da, LIU Meihan, ZHANG Wei, LIAN Meiling*
Key Laboratory of Civil Aviation Thermal Hazards Prevention and Emergency Response, Civil Aviation University of China, Tianjin 300300,China
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摘要 纳米酶的出现是人工模拟酶研究领域的重大进展,突破了以往人工模拟酶催化效率不高的局限性,目前已被广泛应用到疾病诊断和治疗、环境监测及污水处理等多个领域。近年来,人们发现了多种纳米材料具有天然酶活性,并将具有类过氧化物酶活性的纳米材料应用于制备比色生物传感器。借助纳米材料自身所具有的催化能力,模拟类过氧化物酶活性,发挥其成本低、稳定性高和易于储存等优势,直接实现对生化反应的催化,进而通过裸眼观察或以分光光度计检测溶液吸光度变化对目标物进行快速、灵敏的定性定量分析。
具有类过氧化物酶活性的纳米材料在比色传感器中的应用为新型纳米比色传感器的发展提供了更广阔的空间。但是随着研究的不断深入,该类纳米材料也暴露出一些需要改进的问题,如对pH值要求较多、亲和力不够强、催化活性不够高等。针对上述问题,大多的研究都集中于材料的改进和优化。现有的研究表明,可以通过改变材料的结构、增加表面修饰、多种纳米材料复合等方法来进行性能的改进和提升。本文首先明确了比色传感器的显色机制,接着从六种纳米材料(贵金属纳米材料、金属氧化物纳米材料、金属硫化物纳米材料、碳基纳米材料、金属有机骨架、MXene纳米材料)出发详细综述其类过氧化物纳米酶的研究及应用进展,最后概述和讨论了类过氧化物纳米酶当前面临的挑战,明确了纳米材料在比色分析中的地位和未来的发展前景。
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陈达
刘美含
张伟
练美玲
关键词:  纳米酶  类过氧化物酶活性  比色检测  生物传感器    
Abstract: The emergence of nanozymes is a major advancement in the research field of artificial enzymes, breaking through the limitations of previous artificial enzymes with low catalytic efficiency. It has been widely used in many fields, such as disease diagnosis and treatment, environmental monitoring and sewage treatment. In recent years, a variety of nanomaterials with natural enzymatic activity have been discovered, and nanomaterials with peroxidase-like activity have been used to prepare colorimetric biosensors. With the help of the catalytic ability of nanomaterials, the simulation of peroxidase-like activity can be achieved. Taking advantage of its advantages of low cost, high stability and easy storage, the catalysis of biochemical reactions can be directly realized. Therefore, the rapid and sensitive qualitative and quantitative analysis of the target can be achieved by naked eye observation or with a spectrophotometer.
The application of nanomaterials with peroxidase-like activity in colorimetric sensors provides a broader space for the development of new nano-colorimetric sensors. However, as the research expanded,this type of nanomaterials also exposed some problems that needed to be improved, such as specific pH requirements, insufficient affinity and insufficient catalytic activity. In view of these problems, most researchers have focused on the improvement and optimization of materials. Existing research shows that the performance can be improved and enhanced by changing the structure of the material, increasing the surface modification and using composites of various nanomaterials. This review clarifies the color-rendering mechanism of the colorimetric sensor. Then, the research progress and application of peroxidase-like nanozymes are reviewed in detail from the perspective of six types of nanomaterial (precious metal nanomaterials, metal oxide nanomaterials, metal sulfide nanomaterials, carbon-based nanomaterials, metal organic frameworks and MXene nanomaterials). Finally, the current challenges faced in the application of peroxidase-like nanozymes are summarized and discussed, and the status and future development prospects of nanomaterials in colorimetric analysis are elucidated.
Key words:  nanozymes    peroxidase-like activity    colorimetric detection    biosensor
出版日期:  2022-07-10      发布日期:  2022-07-12
ZTFLH:  O65  
基金资助: 中国民航大学科研启动基金项目(2020KYQD07);国家重点研发计划(2018YFF01011700);国家自然科学基金(21973111;61801519)
通讯作者:  * mllian@cauc.edu.cn   
作者简介:  陈达,中国民航大学蓝天学者特聘教授、博士研究生导师,国家重点研发计划首席专家,公安部反恐处突领域专家,雀巢全球研发中心乳品质量安全体系首席研究员。主要从事公共安全智能传感与装备等领域的研究开发工作。近年来,主持国家重点研发计划1项、国家重大科学仪器专项课题任务1项、国家自然科学基金3项、军工涉密项目1项、省部级科研项目4项、重大横向合作项目4项;获国家科技进步二等奖1项,国际学术奖励2项;发表SCI论文64篇;授权发明专利11项、软件著作权13项。
练美玲,中国民航大学讲师,研究方向为功能纳米材料制备及其在传感、生物催化、医药等领域的应用。主持国家自然科学基金青年项目一项,参加多项国家自然科学基金面上项目的研究,参加过 973、863 等国家重大课题的研究工作。近年来在包括Chem.、Anal. Chem.、ACS Appl. Mater. Inter.、Sensor. Actuator. B: Chem.、ACS Appl. Bio Mater. 等国际期刊上发表 SCI 收录论文多篇,申报多项国家发明专利。
引用本文:    
陈达, 刘美含, 张伟, 练美玲. 具有类过氧化物酶活性的纳米材料在比色分析中的研究进展[J]. 材料导报, 2022, 36(13): 20090055-14.
CHEN Da, LIU Meihan, ZHANG Wei, LIAN Meiling. Progress in Colorimetric Analysis of Nanomaterials with Peroxidase-like Activity. Materials Reports, 2022, 36(13): 20090055-14.
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http://www.mater-rep.com/CN/10.11896/cldb.20090055  或          http://www.mater-rep.com/CN/Y2022/V36/I13/20090055
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