Progress in the Application of Bacteriorhodopsin in Biosensors
LIU Wenqing1,2, ZHANG Tao1,3
1 Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083,China
2 University of Chinese Academy of Sciences, Beijing 100049, China
3 Shanghai Tech University, Shanghai 201210, China
Abstract: Biosensor is a comprehensive integrated technology device that crosses multiple disciplines such as biological sensitive materials, physical and chemical transducers, and electrical signal amplification devices. Typical biosensors utilizebioactive materials with specific sensing functions as sensitive elements, combined physical and chemical transducers and conditioning circuits based on microelectronic devices, to rea-lize the conversion of biosensitive information into electrical signals and amplification. The sensitivity and anti-interference ability of transducers directly affect the performance of biosensor. Extracted from halobacterium salinarum, bacteriorhodopsin is a kind of biological material with good photosensitive properties. It can directly convert optical signals into electrical signals to realize the function of combining sensitive elements and transducers. It has been widely used in a variety of biosensors. The photosensitivity and stability of bacteriorhodopsin are suitable for the development of light sensors with color sensitivity, and the earliest application direction is artificial retina. The integration of photosensitivity and energy conversion characteristics can realize the function of optical motion detection using only a single sensor element, and the application can be extended to the field of motion sensing. In addition to its application in the area of vision sensing, bacteriorhodopsin has shown good sensitivity, stability and specificity in pathogen detection, water pH detection, cell membrane potential detection. It not only has application value in the field of biosensor, but also provides a new way for the research of semiconductor sensing methods. In this review, based on the brief introduction of the basic functions of bacteriorhodopsin, such as proton pump and photoelectric response cha-racteristics, the application progress of biosensor based on bacteriorhodopsin is described and the characteristics of different sensors are analyzed, so as to provide reference for the mechanism and application research of rhodopsin.
刘文清, 张涛. 细菌视紫红质在生物传感器中的应用进展[J]. 材料导报, 2021, 35(23): 23171-23182.
LIU Wenqing, ZHANG Tao. Progress in the Application of Bacteriorhodopsin in Biosensors. Materials Reports, 2021, 35(23): 23171-23182.
1 Someya T, Bao Z, Malliaras G G. Nature, 2016, 540,379. 2 Yang S, Zhang S Y, Jiang Y Q, et al. Advanced sensing technology, University of Science and Technology of China Press, China, 2014 (in Chinese). 杨圣, 张韶宇, 蒋依秦, 等.先进传感器技术.中国科学技术大学出版社, 2014. 3 Willner I, Baron R, Willner B. Biosensors and Bioelectronics, 2007, 22,1841. 4 Zhang A, Lieber C M. Chemical Reviews, 2015, 116,215. 5 Li Y T, Tian Y, Tian H, et al. Sensors, 2018, 18(5),1368. 6 Willner I, Willner B. Trends in Biotechnology, 2001,19,222. 7 Shanmugam S, Hari A, Pandey A, et al. Fuel, 2020, 270,117453. 8 Yoon J, Lee T, Choi J W. Micromachines, 2019,10,347. 9 Knoblauch C, Griep M, Friedrich C. Sensors, 2014, 14,19731. 10 Bostick C D, Mukhopadhyay S, Pecht I, et al. Reports on Progress in Physics, 2018, 81,026601. 11 Svechtarova M I, Buzzacchera I, Toebes B J, et al. Electroanalysis, 2016, 28,1201. 12 Apama S, Anil K S. Biotechnology Letters, 2017, 39,1793. 13 Zheng Y. Studies on photochromic properties of bacteriorhodopsin and its applications. Ph.D. Thesis, State Key Laboratory of Transient Optics Technology Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences, China, 2004 (in Chinese). 郑媛. 菌紫质光致变色特性及应用研究. 博士学位论文, 中科院西安光机所, 2004. 14 Hampp N A. Chemical Reviews, 2000,100,1755. 15 Hampp N A. Applied Microbiology and Biotechnology, 2000, 53,633. 16 Wu J. Investigations of proton pumping behaviors of retinal proteins and corresponding material techniques in potential photoactive devices. Ph.D.Thesis, Fudan University, China, 2009 (in Chinese). 吴佳. 视黄醛膜蛋白的质子泵功能及其光响应期间材料的研究. 博士学位论文, 复旦大学, 2009. 17 Hampp N A. Pure and Applied Chemistry, 1996, 68,1361. 18 Luecke H, Schobert B, Richter H T, et al. Journal of Molecular Biology,1999, 291, 899. 19 Muller D J, Kessler M, Oesterhelt F, et al. Biophysical Journal, 2002, 83,3578. 20 Pebay P E, Rummel G, Rosenbusch J P, et al. Science, 1997, 277,1676. 21 Rakovich A, Donegan J F, Oleinikov V, et al. Journal of Photochemistry & Photobiology C Photochemistry Reviews, 2014, 20,17. 22 Kojima K, Shibukawa A, Sudo Y. Biochemistry, 2020, 59,218. 23 Miyazaki S, Matsumoto M, Brier S B. European Biophysics Journal with Biophysics Letters, 2013, 42,257. 24 Wei L. The optical properties of bacterial rhodopsin protein polymer composite film and its application in photonics devices. Master's Thesis, Fudan University, China, 2008 (in Chinese). 魏崃. 细菌视紫红质蛋白聚合物复合膜的光学性质以及在光子学器件方面的应用研究. 硕士学位论文, 复旦大学, 2008. 25 Miyasaka T, Koyama K, Itoh I. Science, 1992, 255,342. 26 Yao B L, Wang Y L, Hu K S, et al. Photochemistry and Photobiology, 2002, 76(5), 545. 27 Yao B L, Wang Y L, Lei M, et al. Biosensors and Bioelectronics, 2003, 19,283. 28 Yao B L, Xu D L, Hou X. Journal of Biomedical Optics, 2003, 8(1),48. 29 Yao B L, Lei M, Wang Y L, et al. Acta Biochimica et Biophysica Sinica, 2002, 34(1), 113(in Chinese). 姚保利, 雷铭, 王英利, 等. 生物化学与生物物理学报, 2002, 34(1),113. 30 Yao B L, Wang Y L, Hu K S, et al. Acta Biochimica et Biophysica Sinica, 2001, 33(4),443(in Chinese). 姚保利, 王英利, 胡坤生, 等.生物化学与生物物理学报, 2001, 33(4),443. 31 Wang W W, Knopf G K, Bassi A S. Biosensors and Bioelectronics, 2006, 21,1309. 32 Edman K, Nollert P, Royant A, et al. Nature, 1999, 401,822. 33 Kobayashi T, Saito T, Ohtani H, et al. Nature, 2001, 414,531. 34 Yang W Z. Study on the absorption and modulated properties and its applications of nano-biological material bacteriorhodopsin. Master's Thesis, State Key Laboratory of Transient Optics Technology Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences, China, 2003 (in Chinese). 杨文正. 纳米生物材料细菌视紫红质的光吸收与光调制特性及其应用研究. 硕士学位论文, 中科院西安光机所, 2003. 35 Wanger N L, Greco J A. Journal of the Royal Society Interface, 2013, 10, 20130197. 36 Wise K J, Gillespie N B, Stuart J A, et al. Trends in Biotechnology, 2002, 20,387. 37 Wang W W, Knopf G K, Bassi A S. In: IEEE Transactions on NanoBioscience. Canada, 2008, pp.249. 38 Miyasaka T, Koyama K. Applied Optics,1993, 32,6371. 39 Choi H G, Jung W C, Min J H, et al. Biosensors and Bioelectronics, 2001,16,925. 40 Choi H G, Min J, Choi J W, et al. Biosensors and Bioelectronics, 1998, 13,1069. 41 Choi H G, Min J, Choi J W, et al. Molecular Crystals and Liquid Crystals, 1999, 327,267. 42 Michael F, Pertti S, Sinikka P, et al. BioSystems, 2000, 54,131. 43 Lensu L, Frydrych M, Parkkinen, J, et al. Optical Materials, 2004, 27, 57. 44 Porod W, Werblin F, Chua L O, et al. Annals of the New York Academy of Sciences, 2004,1013,92. 45 Wang W W, Knopf G K, Bassi A S. In: Proceedings of the 2005 IEEE Conference on Control Applications Toronto. Canada, 2005, pp. 28. 46 Wang W W, Knopf G K, Bassi A S. In: Conference on Optomechantronic Sensors, Actuators and Control. Philadelphia, 2004, pp. 41. 47 Kasai K, Haruyama Y, Yamada T, et al. In: Proceedings of SPIE NanoScience and Engineering. California, 2013, pp. 1. 48 Okada Y, Tanabe T, Mukai T, et al. Synthetic Metals, 2016, 222,249. 49 Takamatsu S, Hoshino Y, Matsumoto K, et al. IEICE Electron Express, 2011,8, 505. 50 Mohammadpour R, Janfaza S. ACS Sustainable Chemistry and Enginee-ring, 2015, 3,809. 51 Zhao X L, Kang X, Chen L, et al. Acta Physica Sinica, 2014, 63(9), 098502. 52 Griep M H, Walczak K, Winder E, et al. In: Conference on Nonobiotronics. San Diego, 2007, pp. 6646. 53 Jin Y, Honig T, Ron I, et al. Chemical Society Reviews, 2008, 37,2422. 54 Ahmadi M, Osei E K, Yeow J T W. Sensors and Actuators B: Chemical, 2012, 166-167,177. 55 Ahmadi M, Yeow J T. Biosensors and Bioelectronics, 2011, 26,2171. 56 Evans P A, Molney P J, Mountford P J. British Journal of Radiology, 2001, 74,537. 57 Wang W W, Knopf G K, Bassi A S. Optical Engineering, 2006, 45,84001. 58 Borshchevskiy V, Round E, Erofeev I, et al. Acta Crystallographica, 2014, 70,2675. 59 Ahmed A, Rushworth J V, Hirst N A, et al. Clinical Microbiology Reviews, 2014, 27,631. 60 Santos M, Agusil J P, Prieto-Simon B, et al. Biosensors and Bioelectro-nics, 2013, 45(1),174. 61 Ichi S E, Leon F, Vossier L, et al. Biosensors and Bioelectronics, 2014, 54,378. 62 Chen H M, Jheng K R, Yu A D. Biosensors and Bioelectronics, 2017, 91,24. 63 Chen H M, Jheng K R, Yu A D, et al. Journal of the Taiwan Institute of Chemical Engineers, 2016, 64,1. 64 Chen H M, Lin C J, Jheng K R. Colloids and Surfaces B Biointerfaces, 2014, 116(14),482. 65 Wang Y, Alocilja E C. Journal of Biological Engineering, 2015, 9,16. 66 Alocilja E C, Jain P, Pryg K. Technology, 2016, 4,194. 67 Wu H H, Liao X Q, Wu X Y. Sensors, 2018, 18,4493. 68 Oesterhe D, Stoecken W. Nature New Biology, 1971, 233(39),149. 69 Mukohata Y, Sugiyama Y, Kunio I, et al. Biochemical and Biophysical Research Communications, 1988, 151,1339. 70 Hochbaum D R, Zhao Y, Farhi S L, et al. Nature Methods, 2014, 11,825. 71 Penzkofer A, Silapetere A, Hegemann P. International Journal of Molecular Sciences, 2019, 20,4086. 72 Cohen A E, Venkatachalam V. Annual Review Of Biophysics, 2014, 43(1),211. 73 Abdelfattah A S, Farhi S L, Zhao Y X, et al. Journal of Neuroscience, 2016, 36(8),2458. 74 Kralgj J M, Hochbaum D R, Douglass A D, et al. Science, 2011, 333,345. 75 Kralgj J M, Douglass A D, Hochbaum D R, et al. Nature Methods, 2012, 9(1),90. 76 Maclaurin D, Venkatachalam V, Lee H, et al. PNAS, 2013, 110(15),5939. 77 Gong Y, Li J Z, Schnitzer M J. PLoS One, 2013, 8(6),e66959. 78 Flytzanis N C, Bedbrook C N, Chiu H, et al. Nature Communications, 2014, 5,4894. 79 Adam Y, Kim J, Lou S, et al. BioRxiv, 2018, 28168. 80 Piatkevich K D, Jung E E, Straub C, et al. Nature Chemical Biology, 2018,14,352. 81 Zou P, Zhao Y, Douglass A D, et al. Nature Communications, 2014, 5,4625. 82 Gong Y, Huang C, Li J Z, et al. Science, 2015, 350,1361. 83 Kannan M, Vasan G, Huang C, et al. Nature Methods, 2018, 15,1108. 84 Dong Q, Huang Y, Song D, et al. Biosensors and Bioelectronics, 2018, 112,136. 85 Robertson B, Lukashev E P. Biophysical Journal, 1995, 68,1507. 86 Rao S Y, Guo Z B, Liang D W, et al. Physical Chemistry Chemical Physics, 2013, 15,15821. 87 Lyu Y J, Yang N N, Li S H, et al. Nano Energy, 2019, 66,104129. 88 Guo Z, Liang D, Rao S Y, et al. Nano Energy, 2015, 11,654. 89 Li H J, Wang M M, Qi G H, et al. Journal of Materials Chemistry A, 2020, 8,1. 90 Oleinkov V A, Solovyeva D O, Zaitsev S Y. Biochemistry, 2020, 85, 196. 91 Bakaraju V, Prasad E S, Meena B, et al. ACS Omega, 2020, 5(17), 9702. 92 Griep M, Winder E, Lueking D, et al. Journal of Nanoscience and Nanotechnology, 2010, 10(9), 6029. 93 Griep M H, Winder E M, Lueking D R, et al. Biochemistry and Molecular Biology International, 2012, 2012,910707. 94 Kvivenkov V, Samokhvalov P, Nabiev I. Biosensors and Bioelectronics, 2019, 137,117. 95 Yao B L, Xu D L. Acta Biochimica et Biophysica Sinica, 1995, 22(2),117 (in Chinese). 姚保利, 徐大纶. 生物化学与生物物理学报, 1995, 22(2),117. 96 Li Y T, Tian H, Zhao H M, et al. Nanoscale, 2018, 10(2),526. 97 Zhou X, Lv F T, Liu L B, et al. Advanced Optical Materials, 2020, 8(1),1901551.
渝公网安备50019002502923号 版权所有：《材料导报》编辑部
2021, Vol. 35 
