纳米酶在传感检测中的应用研究进展

doi:10.11896/cldb.20060177

材料导报

2021, Vol. 35

Issue (19): 19195-19203 https://doi.org/10.11896/cldb.20060177

高分子与聚合物基复合材料

纳米酶在传感检测中的应用研究进展

戈明亮^1,2,3, 李越颖¹, 梁国栋²

1 华南理工大学,聚合物成型加工工程教育部重点实验室,聚合物新型成型装备国家工程研究中心,广州 510640
2 中山大学聚合物复合材料及功能材料教育部重点实验室,广州 510640
3 贵州民族大学材料科学与工程学院,贵阳 550000

Research Progress on Application of Nanozymes in Sensory Detection

GE Mingliang^1,2,3, LI Yueying¹, LIANG Guodong²

1 National Engineering Research Center of Novel Equipment for Polymer Processing, Key Laboratory of Polymer Processing Engineering of Ministry of Education, South China University of Technology, Guangzhou 510640, China
2 Key Laboratory of Polymeric Composite ＆ Functional Materials of Ministry of Education, Sun Yat-sen University, Guangzhou 510640, China
3 School of Material Science and Engineering, Guizhou Minzu University, Guiyang 550000, China

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摘要纳米酶的诞生推动了化学、材料学以及生物学等学科的发展。在纳米技术基础上发展的纳米酶克服了天然酶的诸多缺点,如成本高昂、稳定性差和对储存条件要求苛刻等,在生物传感、免疫分析、癌症诊断和治疗、环境监测等领域应用广泛。本文从纳米酶的分类、纳米酶的催化机理以及其在传感检测中的应用三个方面综述了近年来研究者们在纳米酶领域取得的突出成就。这些优秀的研究成果从基体材料的选择、材料结构的创新、催化机理的探讨等角度丰富了纳米酶的理论,极大地扩展了纳米酶家族的范围,为多种情景下的传感检测方法提供了崭新的思路。此外,本文针对纳米酶的研究现状,分析了其在理论、应用中的不足,并对纳米酶的未来发展方向提出了一些思考和建议。

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	戈明亮
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	梁国栋

关键词: 纳米酶模拟酶过氧化物酶生物传感

Abstract: The birth of nano-enzymes has promoted the development of disciplines such as chemistry, materials science and biology. Nanozymes deve-loped on the basis of nanotechnology overcome many shortcomings of natural enzymes, such as high cost, poor stability, and strict storage requirements, and are widely used in biosensing, immunoassay, cancer diagnosis and treatment, environmental monitoring and other fields. This article summarizes the outstanding achievements made by researchers in the field of nanozymes in three aspects, including the classification of nanozymes, the catalytic mechanism of nanozymes, and their applications in sensing and detection. These excellent research results have enriched the theory of nanozymes from the perspectives of choice of matrix materials, innovation of material structure, and discussion of catalytic mechanism, which has greatly expanded the scope of the nanozyme family and provided sensory detection methods in various scenarios. In addition, we analyze deficiency of nanozymes' theory and application aiming the research status, and give some thoughts and suggestions on the future development direction of nanozymes.

Key words: nanozymes mimic enzyme peroxidase biosensing

出版日期: 2021-10-10 发布日期: 2021-11-03

ZTFLH:

TB332

基金资助: 广东省自然科学基金(2016A030313520);广东省水利科技创新项目(2017-24);中山大学聚合物复合材料及功能材料教育部重点实验室开放基金(PCFM-2017-02);广东省教育厅特色创新类项目(2017KTSCX007);广州市科技计划项目(202102080477)

通讯作者: gml@scut.edu.cn

作者简介: 戈明亮,博士,华南理工大学机械与汽车工程学院副教授,华南理工大学“汽车内饰材料研发中心”主任,核心期刊《塑料科技》编委,中国化工学会化工新材料委员会会员,广东省安全生产协会标准化评审专家。研究领域包括二维层状材料、有机-无机纳米复合材料、功能高分子材料等及其在环境、医药、催化、仿生等领域的应用。

引用本文:

戈明亮, 李越颖, 梁国栋. 纳米酶在传感检测中的应用研究进展[J]. 材料导报, 2021, 35(19): 19195-19203.
GE Mingliang, LI Yueying, LIANG Guodong. Research Progress on Application of Nanozymes in Sensory Detection. Materials Reports, 2021, 35(19): 19195-19203.

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http://www.mater-rep.com/CN/10.11896/cldb.20060177 或 http://www.mater-rep.com/CN/Y2021/V35/I19/19195

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