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材料导报  2023, Vol. 37 Issue (10): 21100129-9    https://doi.org/10.11896/cldb.21100129
  高分子与聚合物基复合材料 |
磁性功能支架用于骨组织工程的研究进展
段晶, 吴佳蕾, 林涛, 邵慧萍*
北京科技大学新材料技术研究院,北京 100083
Research Progress of Magnetic Functional Scaffolds for Bone Tissue Engineering
DUAN Jing, WU Jialei, LIN Tao, SHAO Huiping*
Institute of Advanced Materials and Technology, University of Science and Technology Beijing, Beijing 100083, China
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摘要 支架引导再生在创伤、肿瘤、切除等引起的严重骨缺损的治疗和修复中起着至关重要的作用。目前发展的磁性功能支架已被证明自身或者结合外部磁场可以影响细胞代谢行为,通过磁性环境来促进骨组织再生。特别是其结合外部磁场的作用,可以有效远程控制药物释放和激活细胞表面通道,介导一系列成骨相关通路,诱导细胞分化,促进组织生长、骨缺损再生等反应。同样,磁性支架在热疗、磁共振成像、靶向递送等方面也有着广泛的应用潜能。磁性支架可提高骨组织工程效率,为骨缺损的修复提供了一定保障。本文综述了磁性支架的复合、制备技术、促进骨再生的机制,以及磁场和磁性支架的协同功能,并总结了几种磁性功能支架在骨组织修复工程领域中的研究及应用。
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段晶
吴佳蕾
林涛
邵慧萍
关键词:  磁性纳米颗粒(MNPs)  磁性功能支架  骨修复  骨组织工程    
Abstract: Scaffold-guided regeneration performs an essential function in the therapy of severe bone defects caused by trauma, tumor, resection, etc. Magnetic scaffolds have been demonstrated to influence cellular metabolic behavior by themselves or external magnetic fields. In particular, the synergistic function of magnetic scaffolds and external magnetic fields can effectively control the release of drugs and activate channels on the cell surface to mediate a series of osteogenesis-related pathways, promoting cell differentiation and tissue regeneration. Additionally, the magne-tic scaffolds have potential applications in thermal therapy, magnetic resonance imaging, targeted delivery, etc. The magnetic scaffolds provide a certain guarantee for improving the repair efficiency of bone tissue engineering. The composite methods, preparation technologies and mechanism of promoting bone regeneration for the magnetic scaffolds, as well as the synergistic function of magnetic field and magnetic scaffold, are reviewed in this paper. It also summarizes the applicatory research of several magnetic scaffolds in bone tissue repair engineering.
Key words:  magnetic nanoparticles (MNPs)    magnetic scaffolds    bone repair    bone tissue engineering
出版日期:  2023-05-25      发布日期:  2023-05-23
ZTFLH:  R318.08  
通讯作者:  *邵慧萍,北京科技大学新材料技术研究院教授。1995年毕业于东北大学化学系,获学士学位;2003年、2006年毕业于韩国忠南大学材料科学与工程系,获得硕士、博士学位。目前主要从事3D打印生物医用磁性材料、陶瓷材料、复合材料研究及其应用。在国内外期刊发表学术论文100余篇,其中被SCI、EI收录60余篇。shaohp@ustb.edu.cn   
作者简介:  段晶,2020年6月毕业于河北科技大学,获得工学学士学位。现为北京科技大学新材料技术研究院硕士研究生,在邵慧萍教授的指导下进行研究,目前主要研究领域为磁性生物材料及其复合材料。
引用本文:    
段晶, 吴佳蕾, 林涛, 邵慧萍. 磁性功能支架用于骨组织工程的研究进展[J]. 材料导报, 2023, 37(10): 21100129-9.
DUAN Jing, WU Jialei, LIN Tao, SHAO Huiping. Research Progress of Magnetic Functional Scaffolds for Bone Tissue Engineering. Materials Reports, 2023, 37(10): 21100129-9.
链接本文:  
http://www.mater-rep.com/CN/10.11896/cldb.21100129  或          http://www.mater-rep.com/CN/Y2023/V37/I10/21100129
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