Mechanical Properties and Preparation Strategies of Bone Repair Materials in the Treatment of Large Bone Defects
LIANG Qingyou1,2, DENG Chunlin1,*
1 School of Material Science and Engineering, South China University of Technology, Guangzhou 510640, China 2 Analytical and Testing Center, South China University of Technology, Guangzhou 510640, China
Abstract: Autologous bone graft, which is considered as “the gold standard” in repairing large bone defect (LBD), bears limited sources. Alloys and ceramics lead to bone absorption because of stress shielding. Biodegradable materials have good osteogenesis. However, their mechanical properties do not match natural bones. Thus it is the principal goal for treatment of LBD to endow biomaterials with matched mechanical properties similar to cortical bones. The data of four pairs of relationships for hard tissue repair materials, which involve tensile strength-Young' modulus (E), fracture toughness-E, impact strength (toughness)-E, and E-density, show that all these relationships are located outside the scope of cortical bone's mechanical properties and far beyond the center. The microstructure of bone inspires us to discovery new biomaterials. Bone is actually a kind of strong and tough composite material, where inorganic and organic phases are cross-linked as an independent structure respectively, and the two phases are composited and entangled in the molecular level. Therefore, the hard tissue repair materials ought to contain hydroxyapatite (HAp) and biocompatible polymer(s) and be compo-sited on the nanoscale. Ascidian cellulose (AC) has high modulus and possesses great potentiality to enhance bone repair materials. Mild mol-ding conditions including ionic oligomer cross-linking, cold sintering, and fast sintering methods should be employed for the composition of HAp and AC to obtain cortical-bone-matched materials with proper mechanics. This work enumerates the materials employed in LBD, and the existing problem is emphasized. According to the micro structure of bone, the design and preparation strategies of the composite biomaterials are discussed, which may facilitate the research on biomaterial mechanics.
梁庆优, 邓春林. 长骨大段骨缺损修复材料的力学性能及制备策略[J]. 材料导报, 2021, 35(13): 13100-13108,13118.
LIANG Qingyou, DENG Chunlin. Mechanical Properties and Preparation Strategies of Bone Repair Materials in the Treatment of Large Bone Defects. Materials Reports, 2021, 35(13): 13100-13108,13118.
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