Research Progress in the Preparation and Application of Gadolinium-based Nanoparticles
HU Yanyan1,2, YANG Chunlin3 , QIAO Huina1,2 , OU Meigui1,2
1 College of Materials and Metallurgy, University of Guizhou,Guiyang 550025 2 National Local Joint Engineering Laboratory for High Performance Metal Structure Materials and Manufacturing Technology, Guiyang 550025 3 College of Chemistry and Materials Engineering, Guiyang College, Guiyang 550003
Abstract: In recent years, rare earth elements have attracted extensive attention due to their special 4f electronic structure, relatively large atomic number and unique optical and magnetic properties. Thus, they have been widely adopted in the preparation of rare earth based nanoparticles, especially, the preparation and physicochemical properties of gadolinium-based nanoparticles. The studies demonstrated that the rare earth-based nanomaterials are easily doped with other rare earth as well as metal ions, with good stability, low phonon energy, and a large neutron absorption cross-section, which have been extensively applied in the fields of luminescence, biological and medicine. Researchers have obtained rare earth nanomaterials with various morphologies and microstructures via different preparation methods, for improving their luminescence properties, relaxation properties, drug carrying properties and targeting. so the nanoparticles can be better applied in different fields, such as luminescence, imaging, medical treatment and so on. The gadolinium oxide nanoparticles is mostly prepared by liquid phase method since the operation has the characteristics of simple operation, particle size is controllable and the dispersibility of nanoparticles is good. The rare earth luminescent materials can absorb or emit electromagnetic wave radiation of various wavelengths from ultraviolet to infrared regions. Therefore, to study the influence of different rare earth ions doped gadolinium oxide on their luminescence performance, researchers have also utilized the co-doping of various rare earth ions, rare earth ions and metal ions to achieve the goal of regulating the luminescence, ameliorating the color saturation and the luminescence intensity by adjusting the doping ratio. Gadolinium ion is used as a magnetic resonance contrast agent on account of its seven unpaired electrons. Currently, the most commonly used negative contrast agent in clinic is mainly based on nano-iron oxide, and the positive contrast agent is mainly based on gadolinium-diethylenetriamine pentaacetic(Gd-DTPA). There are few investigations on negative contrast agents since the nano-iron oxide imaging exists a series of problems, such as low signal intensity, dark image and artifacts Gadolinium oxide has higher density of magnetic particles than that of the Gd-DTPA, therefore, the recent research hotspots have been revolved round improving the relaxation properties of gadolinium oxide nanomaterials through optimizing the preparation process, and combining the fluorescence and magnetism of gadoliniumoxide nanomaterials to realize the dual mode detection function of optical magnetic resonance imaging (MRI). Besides, high atomic number of gadolinium can act as a radiosensitizer as well, which may enhance the sensitivity of tumor cells to radiotherapy. Hafnium and bismuth are both sensitizers with radiosensitizating potential as well as the gold, furthermore, the Gd-based sensitizers combining MRI can realize image-guided radiation therapy. Moreover, gadolinium has attached importance to the application of shielding materials due to its higher ray absorption properties than that of the lead. This paper compares several main preparation methods ofgadolinium oxide nanoparticles and their characteristics. The applications of gadoli-nium oxide nanoparticles in luminescent materials, medical treatment and shielding materials are briefly described and finally the existing problems and development directions of gadolinium oxide nanoparticles are pointed out.
作者简介: 胡燕燕,就读于贵州大学。在欧梅桂教授的指导下进行研究,目前主要研究方向为稀土氧化物的合成及其应用。 欧梅桂,贵州大学材料与冶金学院教授,硕士研究生导师。2000年7月本科毕业于贵州大学材料与冶金学院,2009年5月毕业于法国里昂国立应用科学院,并取得博士学位。主要从事功能材料及金属结构材料方面的研究。近年来,在功能材料领域发表多篇论文,包括Ceramics International、Journal of Colloid and Interface Science、The Journal of Physical Chemistry、Photochemistry and Photobiology和Advanced Fonctional Materials等。
引用本文:
胡燕燕, 杨春林, 乔慧娜, 欧梅桂. 钆基稀土纳米颗粒的制备及应用研究进展[J]. 材料导报, 2019, 33(13): 2243-2251.
HU Yanyan, YANG Chunlin , QIAO Huina , OU Meigui. Research Progress in the Preparation and Application of Gadolinium-based Nanoparticles. Materials Reports, 2019, 33(13): 2243-2251.
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2019, Vol. 33 
